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Identification of potential therapeutic targets in prostate cancer through a cross-species approach.
Sarah Jurmeister, Antonio Ramos-Montoya, Chiranjeevi Sandi, Nelma Pértega-Gomes, Karan Wadhwa, Alastair D Lamb, Mark J Dunning, Jan Attig, Jason S Carroll, Lee GD Fryer, Sérgio L Felisbino, David E Neal
Mar 28, 2018
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development...
MELK cross‐species analysis Mouse models new cancer targets prostate cancer Animals Carcinogenesis Cell Line Tumor Cell Proliferation Cell Survival Disease Progression Down-Regulation Gene Expression Profiling Gene Expression Regulation Neoplastic Genome Humans Male Mice Molecular Targeted Therapy Naphthyridines Neoplasm Invasiveness Phenotype Phosphorylation Prostatic Neoplasms Protein Serine-Threonine Kinases Species Specificity Spindle Apparatus Stathmin Transcriptome