Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits
I Tachmazidou,
D Süveges,
JL Min,
GRS Ritchie,
J Steinberg,
K Walter,
V Iotchkova,
J Schwartzentruber,
J Huang,
Y Memari,
S McCarthy,
AA Crawford,
C Bombieri,
M Cocca,
A-E Farmaki,
TR Gaunt,
P Jousilahti,
MN Kooijman,
B Lehne,
G Malerba,
S Männistö,
A Matchan,
C Medina-Gomez,
SJ Metrustry,
A Nag,
I Ntalla,
L Paternoster,
NW Rayner,
C Sala,
WR Scott,
HA Shihab,
L Southam,
B St Pourcain,
M Traglia,
K Trajanoska,
G Zaza,
W Zhang,
MS Artigas,
N Bansal,
M Benn,
Z Chen,
P Danecek,
W-Y Lin,
A Locke,
J Luan,
AK Manning,
A Mulas,
C Sidore,
A Tybjaerg-Hansen,
A Varbo,
M Zoledziewska,
C Finan,
K Hatzikotoulas,
AE Hendricks,
JP Kemp,
A Moayyeri,
K Panoutsopoulou,
M Szpak,
SG Wilson,
M Boehnke,
F Cucca,
E Di Angelantonio,
C Langenberg,
C Lindgren,
MI McCarthy,
AP Morris,
BG Nordestgaard,
RA Scott,
MD Tobin,
NJ Wareham,
SpiroMeta Consortium,
GoT2D Consortium,
P Burton,
JC Chambers,
GD Smith,
G Dedoussis,
JF Felix,
OH Franco,
G Gambaro,
P Gasparini,
CJ Hammond,
A Hofman,
VWV Jaddoe,
M Kleber,
JS Kooner,
M Perola,
C Relton,
SM Ring,
F Rivadeneira,
V Salomaa,
TD Spector,
O Stegle,
D Toniolo,
AG Uitterlinden,
arcOGEN Consortium,
Understanding Society Scientific Group,
UK10K consortium,
I Barroso,
CMT Greenwood,
JRB Perry,
BR Walker,
AS Butterworth,
Y Xue,
R Durbin,
KS Small,
N Soranzo,
NJ Timpson,
E Zeggini
Jul 03, 2017
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome...