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Clinical implications of myelin regeneration in the central nervous system.
Amongst strategies to repair the brain, myelin repair offers genuine cause for optimism. Myelin, which sheaths most axons in the central nervous system (CNS), is vital for normal neurological function, as demonstrated by the...
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.
Björn Neumann, Roey Baror, Chao Zhao, Michael Segel, Sabine Dietmann, Khalil S Rawji, Sarah Foerster, Crystal R McClain, Kevin Chalut, Peter van Wijngaarden, Robin Jm Franklin
Sep 03, 2019
CNS regeneration Adult stem cell aging dietary restriction Metformin oligodendrocyte progenitor cell rejuvenation remyelination aging Animals Cell Differentiation Cells Cultured Central Nervous System DNA Damage Female Humans Hypoglycemic Agents Male Metformin Multiple Sclerosis oligodendrocyte precursor cells Oligodendroglia Rats rejuvenation remyelination Stem Cell Transplantation
Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice
I Kazanis, KA Evans, E Andreopoulou, C Dimitriou, C Koutsakis, RT Karadottir, RJM Franklin
Mar 27, 2017
The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.
Christopher E McMurran, Alerie Guzman de la Fuente, Rosana Penalva, Ofra Ben Menachem-Zidon, Yvonne Dombrowski, John Falconer, Ginez A Gonzalez, Chao Zhao, Fynn N Krause, Adam MH Young, Julian L Griffin, Clare A Jones, Claire Hollins, Markus M Heimesaat, Denise C Fitzgerald, Robin Jm Franklin
Oct 21, 2019
Remyelination and ageing
Remyelination is a neuroprotective regenerative response to demyelination that restores saltatory conduction and decreases the vulnerability of axons to irreversible degeneration. It is a highly efficient process: however, as...