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Tracking Cancer Evolution Reveals Constrained Routes to Metastases
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I Lopez, David Nicol, Tim O'Brien, James Larkin, Stuart Horswell, Mark Stares, Lewis Au, Mariam Jamal-Hanjani, Ben Challacombe, Ashish Chandra, Steve Hazell, Claudia Eichler-Jonsson, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Faiz Jabbar, Lavinia Spain, Sharanpreet Lall, Rosa Guarch, Mary Falzon, Ian Proctor, Lisa Pickering, Martin Gore, Thomas BK Watkins, Sophia Ward, Aengus Stewart, Renzo DiNatale, Maria F Becerra, Ed Reznik, James J Hsieh, Todd A Richmond, George F Mayhew, Samantha M Hill, Catherine D McNally, Carol Jones, Heidi Rosenbaum, Stacey Stanislaw, Daniel L Burgess, Nelson R Alexander, Charles Swanton, PEACE, TRACERx Renal Consortium
Aug 03, 2018
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with...
chromosome instability cytoreductive nephrectomy evolution of metastasis loss of 9p metastasectomy metastasis oligometastasis renal cell cancer solitary metastasis Adult Aged Aged 80 and over Biomarkers Biopsy Carcinoma Renal Cell Chromosome Mapping Chromosomes Human Pair 14 Chromosomes Human Pair 9 Disease Progression Female Humans Kidney Neoplasms Longitudinal Studies Male Middle Aged Mutation Neoplasm Metastasis Phenotype Prospective Studies Thrombosis Treatment Outcome