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Numerous publications have now addressed the principles of designing, analyzing, and reporting the results of stepped-wedge cluster randomized trials. In contrast, there is little research available pertaining to the design and...

admissible design Cluster randomized trial Multiple comparisons optimal design stepped-wedge Cluster Analysis Computer Simulation Hip Fractures Humans Linear Models Randomized Controlled Trials as Topic Research Design Sample Size

We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...

clinical trial group sequential test Sample size re-estimation adaptive design Flexible design optimal design promising zone

Most high-temperature superconducting (HTS) electric devices have been built by employing a superconducting composite cable. These HTS devices generally have large current-carrying capacities. Therefore, the electromagnetic...

3-D FEM Helical cable magnetic flux distribution optimal design Roebel cable

Most high-temperature superconducting (HTS) electric devices have been built by employing a superconducting composite cable. These HTS devices generally have large current-carrying capacities. Therefore, the electromagnetic...

3-D FEM Helical cable magnetic flux distribution optimal design Roebel cable

We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...

clinical trial group sequential test Sample size re-estimation adaptive design Flexible design optimal design promising zone

BACKGROUND: Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many disease areas, it has been argued...

False discovery rate Familywise error-rate Multiple comparisons optimal design power Sample Size Clinical Trials as Topic Data Interpretation Statistical Humans Research Design Sample Size Software Web Browser

Abstract: Background: Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many disease areas, it has...

Software Experimental therapeutics and drug development False discovery rate Familywise error-rate Multiple comparisons optimal design power Sample Size

adaptive design clinical trial optimal design Sample size calculation Research Design Sample Size

Adapting the final sample size of a trial to the evidence accruing during the trial is a natural way to address planning uncertainty. Since the sample size is usually determined by an argument based on the power of the trial, an...

adaptive design conditional power Interim analysis optimal design predictive power sample size recalculation Friends Humans Research Design Sample Size uncertainty