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Cytokine absorption during human kidney perfusion reduces delayed graft function-associated inflammatory gene signature.
John R Ferdinand, Sarah A Hosgood, Tom Moore, Ashley Ferro, Christopher J Ward, Tomas Castro-Dopico, Michael L Nicholson, Menna R Clatworthy
Nov 13, 2020
Transplantation is the optimal treatment for most patients with end-stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to recondition marginal organs; however...
clinical research / practice delayed graft function (DGF) donors and donation: deceased kidney (allograft) function / dysfunction kidney disease: immune / inflammatory kidney transplantation / nephrology organ perfusion and preservation translational research / science Cytokines Delayed Graft Function Graft Survival Humans Kidney Kidney Transplantation Organ Preservation Perfusion Tissue Donors
Observations on the ex situ perfusion of livers for transplantation.
Christopher JE Watson, Vasilis Kosmoliaptsis, Caitlin Pley, Lucy Randle, Corinna Fear, Keziah Crick, Alexander E Gimson, Michael Allison, Sara Upponi, Rebecca Brais, Ina Jochmans, Andrew J Butler
Apr 13, 2018
Normothermic ex situ liver perfusion might allow viability assessment of livers before transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 resulted in transplants. Hepatocellular damage...
clinical research/practice liver allograft function/dysfunction liver transplantation/hepatology metabolism/metabolite organ perfusion and preservation Adult Bile Ducts Biomarkers Female Follow-Up Studies Hepatocytes Humans Liver Transplantation Male Middle Aged Organ Preservation Perfusion Primary Graft Dysfunction Prognosis Reperfusion Injury Tissue Donors Tissue and Organ Procurement Young Adult
Cytokine absorption during human kidney perfusion reduces delayed graft function–associated inflammatory gene signature
John R. Ferdinand, Sarah A. Hosgood, Tom Moore, Ashley Ferro, Christopher J. Ward, Tomas Castro‐Dopico, Michael L. Nicholson, Menna R. Clatworthy
Jun 04, 2021
Original Article Original Articles clinical research / practice delayed graft function (DGF) donors and donation: deceased kidney (allograft) function / dysfunction kidney disease: immune / inflammatory kidney transplantation / nephrology organ perfusion and preservation translational research / science
Published by: American Journal of Transplantation
Response to "Past, Present, and Future of Dynamic Kidney and Liver Preservation and Resuscitation"
We are writing in response to the article written by Jochmans et al [1]. The article is a comprehensive review on the status of preservation and resuscitation techniques in kidney and liver transplantation. It highlights the...
Use of Ex Vivo Normothermic Perfusion for Quality Assessment of Discarded Human Donor Pancreases.
AD Barlow, MO Hamed, DH Mallon, RJ Brais, FM Gribble, MA Scott, WJ Howat, JA Bradley, EM Bolton, GJ Pettigrew, SA Hosgood, ML Nicholson, K Saeb-Parsy
May 19, 2015
Ischaemia reperfusion injury (IRI) organ perfusion and preservation Adolescent Adult Amylases Clinical Decision-Making Delayed Graft Function Donor Selection Female Follow-Up Studies Graft Survival Humans Male Middle Aged Organ Preservation Outcome Assessment Health Care Pancreas Transplantation Perfusion Temperature Tissue and Organ Harvesting
Machine Perfusion of Donor Livers for Transplantation
SA Karangwa, P Dutkowski, P Fontes, PJ Friend, JV Guarrera, JF Markmann, H Mergental, T Minor, C Quintini, M Selzner, K Uygun, CJ Watson, RJ Porte
Nov 17, 2017
With increasing demand for donor organs for transplantation, machine perfusion (MP) promises to be a beneficial alternative preservation method for donor livers, particularly those considered to be of suboptimal quality, also...
Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion
clinical research/practice kidney transplantation/nephrology organ acceptance organ perfusion and preservation Adult Aged Female Graft Rejection Humans Kidney Function Tests Kidney Transplantation Liver Male Organ Preservation Outcome Assessment Health Care Perfusion Tissue Donors Tissue Survival Tissue and Organ Procurement
The use of third-party packed red blood cells during ex situ normothermic machine perfusion of organs for transplantation
Chris J Callaghan, Benedict L Phillips, Theodora Foukaneli, Susan Robinson, Christopher JE Watson
Oct 05, 2020
Ex situ normothermic machine perfusion (NMP) is being used increasingly in the assessment of higher risk deceased donor organs and to facilitate prolonged organ storage. Third-party packed red blood cells (pRBCs) are often used...
Use of ex vivo normothermic machine perfusion after normothermic regional perfusion to salvage a poorly perfused DCD kidney.
Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) have both been used in the procurement and conditioning of abdominal organs from donation after circulatory death donors with reported improved...
clinical research/practice donors and donation: donation after circulatory death (DCD) kidney transplantation/nephrology organ perfusion and preservation organ procurement organ procurement and allocation organ transplantation in general Aged DEATH Extracorporeal Circulation Humans Kidney Male Organ Preservation Perfusion Tissue Donors Tissue Survival Tissue and Organ Procurement