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multi-armed bandit Gittins index response adaptive procedures normally distributed endpoint sequential sampling patient allocation

Umbrella trials are an innovative trial design where different treatments are matched with subtypes of a disease, with the matching typically based on a set of biomarkers. Consequently, when patients can be positive for more...

adaptive design adaptive randomisation constrained randomisation patient allocation Precision Medicine stratified randomisation Bayes Theorem Biomarkers Computer Simulation Humans Random Allocation Research Design

Multi-armed bandit problems (MABPs) are a special type of optimal control problem well suited to model resource allocation under uncertainty in a wide variety of contexts. Since the first publication of the optimal solution of...

Gittins index multi-armed bandit Whittle index patient allocation response adaptive procedures