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Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.
Diana C Rodriguez Camargo, Sean Chia, Joseph Menzies, Benedetta Mannini, Georg Meisl, Martin Lundqvist, Christin Pohl, Katja Bernfur, Veronica Lattanzi, Johnny Habchi, Samuel IA Cohen, Tuomas PJ Knowles, Michele Vendruscolo, Sara Linse
Nov 22, 2021
The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is...