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Cover Image for The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence. View Article
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence.
Morwan M Osman, Jonathan K Shanahan, Frances Chu, Kevin K Takaki, Malte L Pinckert, Antonio J Pagán, Roland Brosch, William H Conrad, Lalita Ramakrishnan
Apr 10, 2022
SignificanceTuberculosis (TB), an ancient disease of humanity, continues to be a major cause of worldwide death. The causative agent of TB, Mycobacterium tuberculosis, and its close pathogenic relative Mycobacterium marinum...
ESAT-6 ESX-1 phagosomal damage Virulence Antigens Bacterial Bacterial Proteins Humans Mycobacterium marinum Mycobacterium tuberculosis Phagosomes Protein Conformation Tuberculoma Type VII Secretion Systems Virulence
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