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Cover Image for Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules. View Article
Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules.
David S Robertson, A Toby Prevost, Jack Bowden
Jul 03, 2018
Seamless phase II/III clinical trials offer an efficient way to select an experimental treatment and perform confirmatory analysis within a single trial. However, combining the data from both stages in the final analysis can...
adaptive seamless designs phase II/III clinical trials treatment selection uniformly minimum variance unbiased estimator Bias Biometry Clinical Trials Phase II as Topic Clinical Trials Phase III as Topic Humans Research Design
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