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AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment
Gareth O Griffiths, Richard FitzGerald, Thomas Jaki, Andrea Corkhill, Helen Reynolds, Sean Ewings, Susannah Condie, Emma Tilt, Lucy Johnson, Mike Radford, Catherine Simpson, Geoffrey Saunders, Sara Yeats, Pavel Mozgunov, Olana Tansley-Hancock, Karen Martin, Nichola Downs, Izabela Eberhart, Jonathan WB Martin, Cristiana Goncalves, Anna Song, Tom Fletcher, Kelly Byrne, David G Lalloo, Andrew Owen, Michael Jacobs, Lauren Walker, Rebecca Lyon, Christie Woods, Jennifer Gibney, Justin Chiong, Nomathemba Chandiwana, Shevin Jacob, Mohammed Lamorde, Catherine Orrell, Munir Pirmohamed, Saye Khoo, AGILE investigators
Jul 28, 2021
ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients
Tom Wilkinson, Rupert Dixon, Clive Page, Miles Carroll, Gareth Griffiths, Ling-Pei Ho, Anthony De Soyza, Timothy Felton, Keir E Lewis, Karen Phekoo, James D Chalmers, Anthony Gordon, Lorcan McGarvey, Jillian Doherty, Robert C Read, Manu Shankar-Hari, Nuria Martinez-Alier, Michael O'Kelly, Graeme Duncan, Roelize Walles, James Sykes, Charlotte Summers, Dave Singh, ACCORD Collaborators
Sep 25, 2020
OBJECTIVES: Stage 1: To evaluate the safety and efficacy of candidate agents as add-on therapies to standard of care (SoC) in patients hospitalised with COVID-19 in a screening stage. Stage 2: To confirm the efficacy of...
covid-19 master protocol Phase II platform study Randomised Antiviral Agents Benzamides Betacoronavirus covid-19 Coronavirus Infections Hospitalization Humans Pandemics Pneumonia Viral Pyrazines Randomized Controlled Trials as Topic SARS-CoV-2 Spike Glycoprotein Coronavirus Standard of Care COVID-19 Drug Treatment