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BACKGROUND: Transcriptome-wide association studies (TWASs) have shown great promise in interpreting the findings from genome-wide association studies (GWASs) and exploring the disease mechanisms, by integrating GWAS and eQTL...

biological networks blood pressure Dirichlet process regression pointwise mutual information TWAS Bayes Theorem Genetic Predisposition to Disease Genome-Wide Association Study Humans Polymorphism Single Nucleotide Quantitative Trait Loci Regression Analysis Transcriptome

Complex diseases are believed to be the consequence of intracellular network(s) involving a range of factors. An improved understanding of a disease-predisposing biological network could lead to better identification of genes...

Genetics biological networks pointwise mutual information Regression Lung cancer Alzheimer’s disease

BACKGROUND: Transcriptome-wide association studies (TWASs) have shown great promise in interpreting the findings from genome-wide association studies (GWASs) and exploring the disease mechanisms, by integrating GWAS and eQTL...

Research TWAS biological networks Dirichlet process regression pointwise mutual information blood pressure