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Type II topoisomerase enzymes are essential for resolving DNA topology problems arising through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of which (TOP2A) accumulates on chromatin during...

C-terminal domain SUMO Centromere CHROMOSOME Mitosis Phosphorylation post-translational modification topoisomerase II alpha Anaphase Cell Line Centromere Chromatin DNA Topoisomerases Type II DNA-Binding Proteins HEK293 Cells Humans Metaphase Phosphorylation Poly-ADP-Ribose Binding Proteins Protein Processing Post-Translational Small Ubiquitin-Related Modifier Proteins Sumoylation

Breast cancer affects one in eight women making it the most common cancer in the United Kingdom, accounting for 15% of all new cancer cases. One of the main challenges in treating breast cancer is the heterogeneous nature of the...

Cell and Developmental Biology Transcription factor Breast Cancer TNBC Protein-Protein Interaction protein complexes cancer therapy PROTAC post-translational modification

Breast cancer affects one in eight women making it the most common cancer in the United Kingdom, accounting for 15% of all new cancer cases. One of the main challenges in treating breast cancer is the heterogeneous nature of the...

Transcription factor protein complexes Breast Cancer Protein-Protein Interaction cancer therapy post-translational modification PROTAC TNBC

PROTAC TNBC Breast Cancer cancer therapy post-translational modification protein complexes Protein-Protein Interaction Transcription factor

NLR innate immunity Signal Transduction post-translational modification RIP2 kinase NOD1/2

Review post-translational modification protein secretion bacterial pathogens bacterial virulence factors Proteomics Methylation Acetylation Glycosylation lipidation

Zuo1 is a component of the eukaryotic Ribosome Associated Complex (RAC), a group of chaperone proteins that associate with the ribosome and aid in the cotranslational folding of nascent proteins. When cells encounter...

protein Prion Zuo1 Yeast Gibson Assembly post-translational modification Biology Life Sciences

Aspartate α-decarboxylase is a pyruvoyl-dependent decarboxylase required for the production of β-alanine in the bacterial pantothenate (vitamin B5) biosynthesis pathway. The pyruvoyl group is formed via the intramolecular...

amino-acid-derived cofactors aspartate decarboxylase post-translational modification pyruvoyl-dependent Enzyme Activation Escherichia coli Glutamate Decarboxylase Models Molecular Mutation Protein Structure Tertiary Threonine

Alternative Splicing conformation Intrinsically Disordered Protein Membrane Proteins post-translational modification

RESEARCH ARTICLE Microbiology and Infectious Disease plant biology post-translational modification Protein Stability lysine acetyltransferase Effector Virulence plant-microbe interactions Other

post-translational modification Acetylation bacterial pathogens bacterial virulence factors Glycosylation lipidation Methylation protein secretion Proteomics Bacteria Bacterial Proteins Protein Processing Post-Translational Proteomics Virulence

Coenzyme A (CoA) is an obligatory cofactor in all branches of life. CoA and its derivatives are involved in major metabolic pathways, allosteric interactions and the regulation of gene expression. Abnormal biosynthesis and...

Coenzyme A metabolic and oxidative stress post-translational modification Proteomics Animals Coenzyme A Cysteine HEK293 Cells Hep G2 Cells Humans Kidney Liver Male Myocardium Organ Specificity Oxidation-Reduction Oxidative Stress Protein Processing Post-Translational Proteins Rabbits Rats Sprague-Dawley Sulfhydryl Compounds

Alzheimer's Disease FTD mutation TREM2 amyloid β Phosphorylation post-translational modification Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Disease Models Animal Membrane Glycoproteins Mice Mice Transgenic Microglia Receptors Immunologic

Pathogens utilize a panoply of effectors to manipulate plant defense. However, despite their importance, relatively little is actually known about regulation of these virulence factors. Here, we show that the effector...

Effector infectious disease lysine acetyltransferase microbiology plant biology plant-microbe interactions post-translational modification Protein Stability Virulence Virulence Plant Diseases Acetylation Fusarium Solanum lycopersicum Virulence Factors