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We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...

clinical trial group sequential test Sample size re-estimation adaptive design Flexible design optimal design promising zone

We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...

clinical trial group sequential test Sample size re-estimation adaptive design Flexible design optimal design promising zone