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Aurora-A regulates the recruitment of TACC3 to the mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, mediated by three motifs...

disorder–order transition Intrinsically Disordered Protein Phosphorylation Protein Kinase protein–protein interaction Aurora Kinase A Cell Line Humans Microtubule-Associated Proteins Protein Conformation alpha-Helical Spindle Apparatus

Wiskott-Aldrich syndrome protein (WASP) activates the actin-related protein 2/3 homolog (Arp2/3) complex and regulates actin polymerization in a physiological setting. Cell division cycle 42 (Cdc42) is a key activator of WASP...

Cdc42 Cell Signaling Cytoskeleton Intrinsically Disordered Protein Protein Conformation protein motif protein–protein interaction small GTPase structure–function Thermodynamics Actins Amino Acid Sequence Animals Binding Sites Crystallography X-Ray Humans Kinetics Neoplasms Protein Binding Regulatory Sequences Nucleic Acid Signal Transduction Wiskott-Aldrich Syndrome Wiskott-Aldrich Syndrome Protein cdc42 GTP-Binding Protein ras Proteins

Intrinsically disordered regions are present in one-third of eukaryotic proteins and are overrepresented in cellular processes such as signaling, suggesting that intrinsically disordered proteins (IDPs) may have a functional...

B cell lymphoma 2 (Bcl-2) family IDP Apoptosis biophysics coupled folding and binding Kinetics Protein Folding protein–protein interaction Thermodynamics φ value