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Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP.
Vaccinia virus (VACV) encodes multiple proteins inhibiting the NF-κB signalling pathway. One of these, A49, targets the E3 ubiquitin ligase β-TrCP, which is responsible for the ubiquitylation and consequential proteosomal...