Search
Results: 7
Assessing Phototoxicity in a Mammalian Cell Line
Rana A Alghamdi, Marino Exposito-Rodriguez, Philip M Mullineaux, Greg N Brooke, Philippe P Laissue
Jan 07, 2022
Phototoxicity is a significant constraint for live cell fluorescence microscopy. Excessive excitation light intensities change the homeostasis of the observed cells. Erroneous and misleading conclusions may be the problematic...
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Tania Capeloa, Justine A Van de Velde, Donatienne d'Hose, Sara G Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P Duhoux, Michael P Murphy, Paolo E Porporato, Bernard Gallez, Pierre Sonveaux
Nov 15, 2022
Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea.
Jose M Bermúdez-Muñoz, Adelaida M Celaya, Ángela García-Mato, Daniel Muñoz-Espín, Lourdes Rodríguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto
Oct 29, 2021
Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to...
Control of mitochondrial superoxide production by reverse electron transport at complex I.
Ellen L Robb, Andrew R Hall, Tracy A Prime, Simon Eaton, Marten Szibor, Carlo Viscomi, Andrew M James, Michael P Murphy
Dec 17, 2018
The generation of mitochondrial superoxide (O2̇̄) by reverse electron transport (RET) at complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but also provides the precursor to H2O2 production in...
RET coenzyme Q Complex I Mitochondria mitochondrial membrane potential reactive oxygen species (ROS) redox signaling Respiration reverse electron transport Superoxide Animals Electron Transport Electron Transport Complex I Female Hydrogen Peroxide Male Mice Mice Inbred C57BL Mitochondria Heart Oxidative Phosphorylation Rats Rats Wistar Signal Transduction Superoxides Ubiquinone
Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Elizabeth C Hinchy, Anja V Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling, Michael P Murphy
Nov 21, 2018
Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal that transmits information from the organelle to the cell. Other mitochondrial signals, such as ATP, are sensed by enzymes, including the...
AMP-activated kinase (AMPK) Hydrogen Peroxide Mitochondria reactive oxygen species (ROS) redox signaling AMP-Activated Protein Kinases Adenosine Diphosphate Adenosine Triphosphate Animals Cell Line Enzyme Activation Humans Hydrogen Peroxide Mice Mitochondria Muscle Fibers Skeletal Oxidation-Reduction Reactive Oxygen Species
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Tania Capeloa, Justine A Van de Velde, Donatienne d'Hose, Sara G Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P Duhoux, Michael P Murphy, Paolo E Porporato, Bernard Gallez, Pierre Sonveaux
Nov 16, 2022
At diagnosis, about 35% of pancreatic cancers are at the locally invasive yet premetastatic stage. Surgical resection is not a treatment option, leaving patients with a largely incurable disease that often evolves to the...
Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea
Bermúdez-Muñoz, Celaya, García-Mato, Muñoz-Espín, Rodríguez-de la Rosa, Serrano, Varela-Nieto
Aug 28, 2021
Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to...