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Results: 6
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.
Björn Neumann, Roey Baror, Chao Zhao, Michael Segel, Sabine Dietmann, Khalil S Rawji, Sarah Foerster, Crystal R McClain, Kevin Chalut, Peter van Wijngaarden, Robin Jm Franklin
Sep 03, 2019
CNS regeneration Adult stem cell aging dietary restriction Metformin oligodendrocyte progenitor cell rejuvenation remyelination aging Animals Cell Differentiation Cells Cultured Central Nervous System DNA Damage Female Humans Hypoglycemic Agents Male Metformin Multiple Sclerosis oligodendrocyte precursor cells Oligodendroglia Rats rejuvenation remyelination Stem Cell Transplantation
Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.
Mario Baumgart, Steffen Priebe, Marco Groth, Nils Hartmann, Uwe Menzel, Luca Pandolfini, Philipp Koch, Marius Felder, Michael Ristow, Christoph Englert, Reinhard Guthke, Matthias Platzer, Alessandro Cellerino
Mar 01, 2016
GAGE Nothobranchius furzeri RNA transport RNA-seq aging history trait hormesis hourglass life ribosome lifespan regulation longevity longitudinal study mitohormesis rejuvenation weighted gene coexpression network analysis (WGCNA) Zebrafish Animals Cyprinodontiformes Longitudinal Studies RNA Sequence Analysis RNA Vertebrates
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.
Khalil S Rawji, Adam MH Young, Tanay Ghosh, Nathan J Michaels, Reza Mirzaei, Janson Kappen, Kathleen L Kolehmainen, Nima Alaeiilkhchi, Brian Lozinski, Manoj K Mishra, Annie Pu, Weiwen Tang, Salma Zein, Deepak K Kaushik, Michael B Keough, Jason R Plemel, Fiona Calvert, Andrew J Knights, Daniel J Gaffney, Wolfram Tetzlaff, Robin Jm Franklin, V Wee Yong
Jan 31, 2020
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming.
Diljeet Gill, Aled Parry, Fátima Santos, Hanneke Okkenhaug, Christopher D Todd, Irene Hernando-Herraez, Thomas M Stubbs, Inês Milagre, Wolf Reik
May 09, 2022
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming.
Dafni Chondronasiou, Diljeet Gill, Lluc Mosteiro, Rocio G Urdinguio, Antonio Berenguer-Llergo, Mònica Aguilera, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathasan, Maria Abad, Daniel E Martin-Herranz, Camille Stephan-Otto Attolini, Neus Prats, Guido Kroemer, Mario F Fraga, Wolf Reik, Manuel Serrano
Apr 02, 2022
The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, partial and reversible reprogramming...
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming.
Diljeet Gill, Aled Parry, Fátima Santos, Hanneke Okkenhaug, Christopher D Todd, Irene Hernando-Herraez, Thomas M Stubbs, Inês Milagre, Wolf Reik
Apr 21, 2022