Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
FR Day,
DJ Thompson,
H Helgason,
DI Chasman,
H Finucane,
P Sulem,
KS Ruth,
S Whalen,
AK Sarkar,
E Albrecht,
E Altmaier,
M Amini,
CM Barbieri,
T Boutin,
A Campbell,
E Demerath,
A Giri,
C He,
JJ Hottenga,
R Karlsson,
I Kolcic,
P-R Loh,
KL Lunetta,
M Mangino,
B Marco,
G McMahon,
SE Medland,
IM Nolte,
R Noordam,
T Nutile,
L Paternoster,
N Perjakova,
E Porcu,
LM Rose,
KE Schraut,
AV Segrè,
AV Smith,
L Stolk,
A Teumer,
IL Andrulis,
S Bandinelli,
MW Beckmann,
J Benitez,
S Bergmann,
M Bochud,
E Boerwinkle,
SE Bojesen,
MK Bolla,
JS Brand,
H Brauch,
H Brenner,
L Broer,
T Brüning,
JE Buring,
H Campbell,
E Catamo,
S Chanock,
G Chenevix-Trench,
T Corre,
FJ Couch,
DL Cousminer,
A Cox,
L Crisponi,
K Czene,
G Davey Smith,
EJCN de Geus,
R de Mutsert,
I De Vivo,
J Dennis,
P Devilee,
I Dos-Santos-Silva,
AM Dunning,
JG Eriksson,
PA Fasching,
L Fernández-Rhodes,
L Ferrucci,
D Flesch-Janys,
L Franke,
M Gabrielson,
I Gandin,
GG Giles,
H Grallert,
DF Gudbjartsson,
P Guénel,
P Hall,
E Hallberg,
U Hamann,
TB Harris,
CA Hartman,
G Heiss,
MJ Hooning,
JL Hopper,
F Hu,
DJ Hunter,
MA Ikram,
HK Im,
M-R Järvelin,
PK Joshi,
D Karasik,
M Kellis,
Z Kutalik,
G Lachance,
D Lambrechts,
C Langenberg,
LJ Launer,
JSE Laven,
S Lenarduzzi,
J Li,
PA Lind,
S Lindstrom,
Y Liu,
J Luan,
R Mägi,
A Mannermaa,
H Mbarek,
MI McCarthy,
C Meisinger,
T Meitinger,
C Menni,
A Metspalu,
K Michailidou,
L Milani,
RL Milne,
GW Montgomery,
AM Mulligan,
MA Nalls,
P Navarro,
H Nevanlinna,
DR Nyholt,
AJ Oldehinkel,
TA O'Mara,
S Padmanabhan,
A Palotie,
N Pedersen,
A Peters,
J Peto,
PDP Pharoah,
A Pouta,
P Radice,
I Rahman,
SM Ring,
A Robino,
FR Rosendaal,
I Rudan,
R Rueedi,
D Ruggiero,
CF Sala,
MK Schmidt,
RA Scott,
M Shah,
R Sorice,
MC Southey,
U Sovio,
M Stampfer,
M Steri,
K Strauch,
T Tanaka,
E Tikkanen,
NJ Timpson,
M Traglia,
T Truong,
JP Tyrer,
AG Uitterlinden,
DRV Edwards,
V Vitart,
U Völker,
P Vollenweider,
Q Wang,
E Widen,
KW van Dijk,
G Willemsen,
R Winqvist,
BHR Wolffenbuttel,
JH Zhao,
M Zoledziewska,
M Zygmunt,
BZ Alizadeh,
DI Boomsma,
M Ciullo,
F Cucca,
T Esko,
N Franceschini,
C Gieger,
V Gudnason,
C Hayward,
P Kraft,
DA Lawlor,
PKE Magnusson,
NG Martin,
DO Mook-Kanamori,
EA Nohr,
O Polasek,
D Porteous,
AL Price,
PM Ridker,
H Snieder,
TD Spector,
D Stöckl,
D Toniolo,
S Ulivi,
JA Visser,
H Völzke,
NJ Wareham,
JF Wilson,
Lifelines Cohort Study,
InterAct Consortium,
kConFab/AOCS Investigators,
Endometrial Cancer Association Consortium,
Ovarian Cancer Association Consortium,
PRACTICAL Consortium,
AB Spurdle,
U Thorsteindottir,
KS Pollard,
DF Easton,
JY Tung,
J Chang-Claude,
D Hinds,
A Murray,
JM Murabito,
K Stefansson,
KK Ong,
JRB Perry
May 04, 2017
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to ~370,000 women, we identify 389 independent...