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Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
FR Day, DJ Thompson, H Helgason, DI Chasman, H Finucane, P Sulem, KS Ruth, S Whalen, AK Sarkar, E Albrecht, E Altmaier, M Amini, CM Barbieri, T Boutin, A Campbell, E Demerath, A Giri, C He, JJ Hottenga, R Karlsson, I Kolcic, P-R Loh, KL Lunetta, M Mangino, B Marco, G McMahon, SE Medland, IM Nolte, R Noordam, T Nutile, L Paternoster, N Perjakova, E Porcu, LM Rose, KE Schraut, AV Segrè, AV Smith, L Stolk, A Teumer, IL Andrulis, S Bandinelli, MW Beckmann, J Benitez, S Bergmann, M Bochud, E Boerwinkle, SE Bojesen, MK Bolla, JS Brand, H Brauch, H Brenner, L Broer, T Brüning, JE Buring, H Campbell, E Catamo, S Chanock, G Chenevix-Trench, T Corre, FJ Couch, DL Cousminer, A Cox, L Crisponi, K Czene, G Davey Smith, EJCN de Geus, R de Mutsert, I De Vivo, J Dennis, P Devilee, I Dos-Santos-Silva, AM Dunning, JG Eriksson, PA Fasching, L Fernández-Rhodes, L Ferrucci, D Flesch-Janys, L Franke, M Gabrielson, I Gandin, GG Giles, H Grallert, DF Gudbjartsson, P Guénel, P Hall, E Hallberg, U Hamann, TB Harris, CA Hartman, G Heiss, MJ Hooning, JL Hopper, F Hu, DJ Hunter, MA Ikram, HK Im, M-R Järvelin, PK Joshi, D Karasik, M Kellis, Z Kutalik, G Lachance, D Lambrechts, C Langenberg, LJ Launer, JSE Laven, S Lenarduzzi, J Li, PA Lind, S Lindstrom, Y Liu, J Luan, R Mägi, A Mannermaa, H Mbarek, MI McCarthy, C Meisinger, T Meitinger, C Menni, A Metspalu, K Michailidou, L Milani, RL Milne, GW Montgomery, AM Mulligan, MA Nalls, P Navarro, H Nevanlinna, DR Nyholt, AJ Oldehinkel, TA O'Mara, S Padmanabhan, A Palotie, N Pedersen, A Peters, J Peto, PDP Pharoah, A Pouta, P Radice, I Rahman, SM Ring, A Robino, FR Rosendaal, I Rudan, R Rueedi, D Ruggiero, CF Sala, MK Schmidt, RA Scott, M Shah, R Sorice, MC Southey, U Sovio, M Stampfer, M Steri, K Strauch, T Tanaka, E Tikkanen, NJ Timpson, M Traglia, T Truong, JP Tyrer, AG Uitterlinden, DRV Edwards, V Vitart, U Völker, P Vollenweider, Q Wang, E Widen, KW van Dijk, G Willemsen, R Winqvist, BHR Wolffenbuttel, JH Zhao, M Zoledziewska, M Zygmunt, BZ Alizadeh, DI Boomsma, M Ciullo, F Cucca, T Esko, N Franceschini, C Gieger, V Gudnason, C Hayward, P Kraft, DA Lawlor, PKE Magnusson, NG Martin, DO Mook-Kanamori, EA Nohr, O Polasek, D Porteous, AL Price, PM Ridker, H Snieder, TD Spector, D Stöckl, D Toniolo, S Ulivi, JA Visser, H Völzke, NJ Wareham, JF Wilson, Lifelines Cohort Study, InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL Consortium, AB Spurdle, U Thorsteindottir, KS Pollard, DF Easton, JY Tung, J Chang-Claude, D Hinds, A Murray, JM Murabito, K Stefansson, KK Ong, JRB Perry
May 04, 2017
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to ~370,000 women, we identify 389 independent...
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