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Bayesian methods closed testing Multiple comparisons response-adaptive randomization Type I error Adaptive Clinical Trials as Topic Bias Computer Simulation Humans Hypercholesterolemia Models Statistical Random Allocation Research Design

Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on...

adaptive design Network model response-adaptive randomization