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Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18 F-GE-180 and comparison with 18 F-FDG and DCE-MRI
Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer, Pilar Jimenez-Royo
Dec 22, 2020
Abstract: Purpose: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Jan 27, 2020
PURPOSE:While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Feb 13, 2020
PURPOSE: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Feelings of competence and relatedness during physical activity are related to well-being in rheumatoid arthritis patients
P. C. Rouse, J. L. Duda, J. J. Veldhuijzen Van Zanten, G. S. Metsios, N. Ntoumanis, C.- A. Yu, G. D. Kitas
Jun 01, 2013
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes joint pain, swelling and stiffness with eventual structural damage leading to physical dysfunction. Consequently, people with RA tend to...
physical activity Wellbeing rheumatoid arthritis Patient human Rheumatology rheumatic disease Competence Exercise satisfaction Arm fatigue psychological well being Basic needs Anxiety hospital Arthralgia inflammatory disease organization and management distress syndrome follow up correlation coefficient Rigidity Depression swelling /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Feelings of competence and relatedness during physical activity are related to well-being in rheumatoid arthritis patients
P. C. Rouse, J. L. Duda, J. J. Veldhuijzen Van Zanten, G. S. Metsios, N. Ntoumanis, C.- A. Yu, G. D. Kitas
Jun 01, 2013
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes joint pain, swelling and stiffness with eventual structural damage leading to physical dysfunction. Consequently, people with RA tend to...
physical activity Wellbeing rheumatoid arthritis Patient human Rheumatology rheumatic disease Competence Exercise satisfaction Arm fatigue psychological well being Basic needs Anxiety hospital Arthralgia inflammatory disease organization and management distress syndrome follow up correlation coefficient Rigidity Depression swelling /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Predictors of heart rate recovery following exercise in patients with rheumatoid arthritis
Background Cardiovascular disease (CVD) is a major cause of death in rheumatoid arthritis patients (RA). The underlying mechanisms for the CVD increase risk in RA are not fully understood. However, poor parasympathetic function...
Fibrinogen marker C reactive protein triacylglycerol Lipid Heart Rate Exercise Patient human rheumatoid arthritis Rheumatology rheumatic disease Risk factor risk parasympathetic tone Quality of life parasympathetic function leukocyte Exercise Tolerance FITNESS breathing longitudinal study linear regression analysis treadmill Framingham risk score insulin sensitivity Oxygen Consumption Exercise Test cardiovascular disease POPULATION erythrocyte sedimentation rate Mortality Gender blood sampling Female gas analysis Cause of Death Quantitative Insulin Sensitivity Check Index electrocardiogram /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Associations between objective and self-reported physical activity data in rheumatoid arthritis patients
C.-A. Yu, P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, N. Ntoumanis, G. Kitas, J. Duda
Jun 01, 2014
Background Rheumatoid arthritis (RA) patients suffer from periodic flare-ups causing joint swelling, pain and potential bone destruction. In addition, RA patient are at greater risk of cardiovascular disease. Therefore, physical...
rheumatoid arthritis Patient human Rheumatology rheumatic disease physical activity Sitting Exercise Accelerometry Pain Walking joint swelling questionnaire accelerometer Self Report dental floss cardiovascular disease convergent validity risk bone destruction Female /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Associations between objective and self-reported physical activity data in rheumatoid arthritis patients
C.-A. Yu, P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, N. Ntoumanis, G. Kitas, J. Duda
Jun 01, 2014
Background Rheumatoid arthritis (RA) patients suffer from periodic flare-ups causing joint swelling, pain and potential bone destruction. In addition, RA patient are at greater risk of cardiovascular disease. Therefore, physical...
rheumatoid arthritis Patient human Rheumatology rheumatic disease physical activity Sitting Exercise Accelerometry Pain Walking joint swelling questionnaire accelerometer Self Report dental floss cardiovascular disease convergent validity risk bone destruction Female /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Predictors of heart rate recovery following exercise in patients with rheumatoid arthritis
Background Cardiovascular disease (CVD) is a major cause of death in rheumatoid arthritis patients (RA). The underlying mechanisms for the CVD increase risk in RA are not fully understood. However, poor parasympathetic function...
Fibrinogen marker C reactive protein triacylglycerol Lipid Heart Rate Exercise Patient human rheumatoid arthritis Rheumatology rheumatic disease Risk factor risk parasympathetic tone Quality of life parasympathetic function leukocyte Exercise Tolerance FITNESS breathing longitudinal study linear regression analysis treadmill Framingham risk score insulin sensitivity Oxygen Consumption Exercise Test cardiovascular disease POPULATION erythrocyte sedimentation rate Mortality Gender blood sampling Female gas analysis Cause of Death Quantitative Insulin Sensitivity Check Index electrocardiogram /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Identification of immunostimulatory dendritic cells in the synovial effusions of patients with rheumatoid arthritis
Dendritic cells in the circulation are leukocytes that are rich in Ia antigens and that actively stimulate T cell replication. We have identified dendritic cells in the joint effusions of patients with rheumatoid arthritis. By...
Published by: Rockefeller University
Motivation contributes to the physical and psychological health of rheumatoid arthritis patients, above and beyond physical activity behaviour
P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, C.-A. Yu, N. Ntoumanis, G. Kitas, J.L. Duda
Jun 01, 2014
Background Patients with Rheumatoid Arthritis (RA) can participate in regular physical activity (PA) without disease aggravation and accrue health benefits, including enhanced physical and psychological health [1]. However...
C reactive protein motivation HEALTH rheumatoid arthritis Patient human physical activity Rheumatology rheumatic disease questionnaire Depression Regression Analysis Health Assessment Questionnaire Hospital Anxiety and Depression Scale Exercise health practitioner disease exacerbation MODEL disease activity Health Behavior Female /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Motivation contributes to the physical and psychological health of rheumatoid arthritis patients, above and beyond physical activity behaviour
P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, C.-A. Yu, N. Ntoumanis, G. Kitas, J.L. Duda
Jun 01, 2014
Background Patients with Rheumatoid Arthritis (RA) can participate in regular physical activity (PA) without disease aggravation and accrue health benefits, including enhanced physical and psychological health [1]. However...
C reactive protein motivation HEALTH rheumatoid arthritis Patient human physical activity Rheumatology rheumatic disease questionnaire Depression Regression Analysis Health Assessment Questionnaire Hospital Anxiety and Depression Scale Exercise health practitioner disease exacerbation MODEL disease activity Health Behavior Female /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The subjective vitality scale is an indicator of physical and psychological health amongst rheumatoid arthritis patients
P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, C.-A. Yu, N. Ntoumanis, G. Kitas, J.L. Duda
Jun 01, 2014
Background Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory arthritis characterized by periods of remission and flares in disease activity unique to each individual. Consequently, patients with RA experience...
C reactive protein rheumatoid arthritis Patient human Rheumatology rheumatic disease HEALTH FITNESS disease activity fatigue Anxiety Quality of life convergent validity Wellbeing questionnaire Exercise Tolerance Remission health care personnel laryngeal mask blood sampling Health Assessment Questionnaire Hospital Anxiety and Depression Scale Gender Female /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The subjective vitality scale is an indicator of physical and psychological health amongst rheumatoid arthritis patients
P. Rouse, J. Veldhuijzen Van Zanten, G. Metsios, C.-A. Yu, N. Ntoumanis, G. Kitas, J.L. Duda
Jun 01, 2014
Background Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory arthritis characterized by periods of remission and flares in disease activity unique to each individual. Consequently, patients with RA experience...
C reactive protein rheumatoid arthritis Patient human Rheumatology rheumatic disease HEALTH FITNESS disease activity fatigue Anxiety Quality of life convergent validity Wellbeing questionnaire Exercise Tolerance Remission health care personnel laryngeal mask blood sampling Health Assessment Questionnaire Hospital Anxiety and Depression Scale Gender Female /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity.
James I Robinson, Md Yuzaiful Md Yusof, Vinny Davies, Dawn Wild, Michael Morgan, John C Taylor, Yasser El-Sherbiny, David L Morris, Lu Liu, Andy C Rawstron, Maya H Buch, Darren Plant, Heather J Cordell, John D Isaacs, Ian N Bruce, Paul Emery, Anne Barton, Timothy J Vyse, Jennifer H Barrett, Edward M Vital, Ann W Morgan, MATURA Consortia, MASTERPLANS Consortia
Dec 14, 2022
BACKGROUND: Rituximab is widely used to treat autoimmunity but clinical response varies. Efficacy is determined by the efficiency of B-cell depletion, which may depend on various Fc gamma receptor (FcγR)-dependent mechanisms....
Autonomy support, light physical activity and psychological well-being in Rheumatoid Arthritis
Sally A M Fenton, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Peter C. Rouse, Chen-an Yu, George D Kitas, Joan L. Duda
Mar 01, 2018
Background Participation in physical activity may improve psychological well-being among people with Rheumatoid Arthritis (RA). This study examined the implications of autonomy support for physical activity, on objectively...
accelerometer autonomy support functional disability Light physical activity psychological well-being rheumatoid arthritis /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Autonomy support, light physical activity and psychological well-being in Rheumatoid Arthritis
Sally A M Fenton, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Peter C. Rouse, Chen-an Yu, George D Kitas, Joan L. Duda
Mar 01, 2018
Background Participation in physical activity may improve psychological well-being among people with Rheumatoid Arthritis (RA). This study examined the implications of autonomy support for physical activity, on objectively...
accelerometer autonomy support functional disability Light physical activity psychological well-being rheumatoid arthritis /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.
Andrew YF Li Yim, Enrico Ferrero, Klio Maratou, Huw D Lewis, George Royal, David F Tough, Chris Larminie, Marcel MAM Mannens, Peter Henneman, Wouter J de Jonge, Marleen GH van de Sande, Danielle M Gerlag, Rab K Prinjha, Paul P Tak
May 06, 2021
In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative...
DNA Methylation Arthralgia multi-omics analyses rheumatoid arthritis synovial biopsies target identification transcriptomics Adult Aged Aged 80 and over Arthralgia Arthritis Rheumatoid Arthroscopy Biopsy DNA Methylation Epigenesis Genetic Female Humans Male Middle Aged RNA-seq Severity of Illness Index Synovial Membrane whole genome sequencing Young Adult
Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM).
Sofia Ramiro, Robert Bm Landewé, Désirée van der Heijde, Alexandre Sepriano, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Ori Elkayam, J Carter Thorne, Margaret Larche, Gianfranco Ferraccioli, Marina Backhaus, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain G Cantagrel, Cornelia F Allaart, Cheryl Barnabe, Clifton O Bingham, Paul P Tak, Dirkjan van Schaardenburg, Hilde Berner Hammer, Rana Dadashova, Edna Hutchings, Joel Paschke, Walter P Maksymowych
Feb 25, 2020
OBJECTIVES: To investigate whether following a treat-to-target (T2T)-strategy in daily clinical practice leads to more patients with rheumatoid arthritis (RA) meeting the remission target. METHODS: RA patients from 10 countries...
Remission rheumatoid arthritis treat-to-target Adult Aged Antirheumatic Agents Arthritis Rheumatoid Blood Sedimentation C-Reactive Protein Clinical Decision-Making Cohort Studies Female Humans Longitudinal Studies Male Middle Aged Patient Care Planning Remission Induction Rheumatoid Factor Tumor Necrosis Factor Inhibitors
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study)
Mariam Al-Laith, Marianna Jasenecova, Sonya Abraham, Aisla Bosworth, Ian N Bruce, Christopher D Buckley, Coziana Ciurtin, Maria-Antonietta D'Agostino, Paul Emery, Hill Gaston, John D Isaacs, Andrew Filer, Benjamin A Fisher, Thomas WJ Huizinga, Pauline Ho, Clare Jacklin, Heidi Lempp, Iain B McInnes, Arthur G Pratt, Andrew Östor, Karim Raza, Peter C Taylor, Dirkjan van Schaardenburg, Dharshene Shivapatham, Alison J Wright, Joana C Vasconcelos, Joanna Kelly, Caroline Murphy, A Toby Prevost, Andrew P Cope
Jul 14, 2020
TRIAL DESIGN: We present a study protocol for a multi-centre, randomised, double-blind, parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and effectiveness of a 52-week period of...
Abatacept Antibodies to citrullinated protein antigens At risk Autoantibodies Double-blind intervention Placebo-controlled Pre-clinical phase Randomised rheumatoid arthritis Abatacept Antirheumatic Agents Arthritis Rheumatoid Autoantibodies Biomarkers Double-Blind Method Drug Administration Schedule Feasibility Studies Female Humans Male Multicenter Studies as Topic Netherlands Pregnancy Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom