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Although mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), approximately 10-15% of all ILCs retain membrane-localized E-cadherin despite the presence of an apparent...

E-cadherin Rho/Rock lobular breast cancer mouse model α-catenin (CTNNA1) Actomyosin Adherens Junctions Animals Anoikis Antigens CD Breast Neoplasms Cadherins Carcinoma Lobular Cell Adhesion Cell Proliferation Cell Shape Female Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Humans MCF-7 Cells Mice Knockout Mutation Neoplasm Invasiveness Phenotype Signal Transduction Tumor Suppressor Protein p53 Tumor Suppressor Proteins alpha Catenin rho GTP-Binding Proteins rho-Associated Kinases

Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide...

GLUT4 glucose transporter Rho GEF Rho GTPase Glucose homeostasis glucose-stimulated insulin secretion guanine nucleotide exchange factor insulin-stimulated glucose uptake Metabolic Syndrome small G protein Type 2 diabetes Animals Glucose Homeostasis Humans Insulin Models Biological Rho Guanine Nucleotide Exchange Factors rho GTP-Binding Proteins

The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated...

FLIM-FRET actin Biosensors Breast Cancer Cell Biology development immunology intravital imaging pancreatic cancer small GTPase RhoA Animals Antineoplastic Agents Biosensing Techniques Bone and Bones Cell Movement Dasatinib Erlotinib Hydrochloride Female Fluorescence Resonance Energy Transfer Gene Expression Regulation Intestine Small Intravital Microscopy Mammary Glands Animal Mammary Neoplasms Experimental Mechanotransduction Cellular Mice Mice Transgenic Neutrophils Osteocytes Pancreatic Neoplasms Time-Lapse Imaging rho GTP-Binding Proteins rhoA GTP-Binding Protein

BACKGROUND: RhoA is an important regulator of platelet responses downstream of Gα13 , yet we still know little about its regulation in platelets. Leukemia-associated Rho guanine-nucleotide exchange factor (GEF [LARG]), a RhoA...

Larg protein mouse RhoA protein mouse gene knockout MOUSE platelets Thrombosis 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Adenosine Diphosphate Animals Blood Platelets Cell Degranulation Chlorides Crosses Genetic Ferric Compounds Gene Knockout Techniques Mice Mice Knockout Oligopeptides Organ Specificity Platelet Activation Platelet Aggregation Rho Guanine Nucleotide Exchange Factors Thrombosis rho GTP-Binding Proteins rhoA GTP-Binding Protein

Amino Acid Sequence Cell Membrane GTP-Binding Proteins Guanine Nucleotide Dissociation Inhibitors HEK293 Cells Humans Monomeric GTP-Binding Proteins Protein Binding rho GTP-Binding Proteins rho Guanine Nucleotide Dissociation Inhibitor alpha rho Guanine Nucleotide Dissociation Inhibitor beta rho Guanine Nucleotide Dissociation Inhibitor gamma rho-Specific Guanine Nucleotide Dissociation Inhibitors

Adaptor Proteins Signal Transducing Calorimetry GTPase-Activating Proteins Guanine Nucleotide Exchange Factors HEK293 Cells HeLa Cells Humans Immunoblotting Kinetics Microscopy Electron Phosphorylation rac1 GTP-Binding Protein rho GTP-Binding Proteins

Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such...

Cdc42 GTPase activating proteins Rac1 RhoA guanosine nucleotide exchange factors metabolism muscle mass muscle regeneration Myogenesis PAK Rock satellite cells signaling small G protein Animals Homeostasis Humans Muscle Development Muscle Skeletal Muscular Diseases Regeneration rho GTP-Binding Proteins

Algorithms Anti-Infective Agents Anti-Inflammatory Agents Antigen Presentation Autophagosomes Bayes Theorem Cell Cycle Checkpoints Cell Membrane Cell Nucleus Cell Shape Humans Immunity Inflammation Leukemia Lipopolysaccharides Lymphocyte Activation Lysosomes Neoplasm Proteins Protein Transport Proteome Proteomics Signal Transduction T-Lymphocytes THP-1 Cells Time Factors Transport Vesicles Up-Regulation rho GTP-Binding Proteins

DOCK proteins are a family of multi-domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase-dependent cellular processes. DOCK proteins are...

Cdc42 DOCK proteins Rac1 Guanine Nucleotide Exchange Factors Guanine Nucleotide Exchange Factors cdc42 GTP-Binding Protein rho GTP-Binding Proteins Signal Transduction Nucleotides Biology rac1 GTP-Binding Protein

In many organisms, the small guanosine triphosphatase RhoA controls assembly and contraction of the actomyosin ring during cytokinesis by activating different effectors. Although the role of some RhoA effectors like formins and...

Animals Cytokinesis Drosophila Drosophila Proteins Intracellular Signaling Peptides and Proteins Protein Serine-Threonine Kinases rho GTP-Binding Proteins

Argonaute Proteins Cell Cycle GTP-Binding Protein gamma Subunits Humans Oligonucleotide Array Sequence Analysis Protein Isoforms RNA Interference RNA Polymerase III RNA Long Noncoding rho GTP-Binding Proteins

To introduce pits into a cell wall, plants depolymerize cortical microtubules, which prevents subsequent secondary cell wall thickening. A newly identified protein tethers microtubules to the plasma membrane and contains this...

Cell Membrane Cell Wall Microtubules Xylem rho GTP-Binding Proteins

Rho GTPase-based signaling networks control cellular dynamics by coordinating protrusions and retractions in space and time. Here, we reveal a signaling network that generates pulses and propagating waves of cell contractions....

Actin Cytoskeleton Actomyosin Biomechanical Phenomena Cell Line Tumor Gene Expression Regulation HeLa Cells Humans Mechanotransduction Cellular Microtubules Myosins Osteoblasts Rho Guanine Nucleotide Exchange Factors rho GTP-Binding Proteins