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Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E.
Md Saiful Islam
,
Katarzyna J Bandyra
,
Yanjie Chao
,
Jörg Vogel
,
Ben F Luisi
Jul 27, 2021
The conserved endoribonuclease RNase E dominates the dynamic landscape of RNA metabolism and underpins control mediated by small regulatory RNAs in diverse bacterial species. We explored the enzyme's hydrolytic mechanism...
RNA degradosome
RNA recognition
modified RNA
pseudouridine
ribonuclease mechanism
riboregulation
Binding Sites
Endoribonucleases
Escherichia coli
Escherichia coli Proteins
Multienzyme Complexes
Nucleic Acid Conformation
Polyribonucleotide Nucleotidyltransferase
Protein Conformation
pseudouridine
RNA Helicases
RNA
Bacterial
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