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A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation.
Tom Dendooven, Dhriti Sinha, Alzbeta Roeselová, Todd A Cameron, Nicholas R De Lay, Ben F Luisi, Katarzyna J Bandyra
May 28, 2021
Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the course of evolution and is found in species as diverse as bacteria and humans. Paradoxically, Escherichia coli PNPase can act not only as an...
Hfq RNA chaperone cryoEM Gene Silencing polynucleotide phosphorylase Ribonuclease ribonucleoprotein complex riboregulation small regulatory RNA Catalytic Domain Endoribonucleases Escherichia coli Escherichia coli Proteins Exoribonucleases Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Chaperones Polyribonucleotide Nucleotidyltransferase RNA Stability RNA Bacterial RNA Small Untranslated
RATA
Long non-coding RNAs (lncRNAs) regulate critical cellular processes and their dysregulation contributes to multiple diseases. Although only a few lncRNAs have defined mechanisms, many of these characterized lncRNAs interact with...