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Results: 9
The use of duplex-specific nuclease in ribosome profiling and a user-friendly software package for Ribo-seq data analysis.
Betty Y Chung, Thomas J Hardcastle, Joshua D Jones, Nerea Irigoyen, Andrew E Firth, David C Baulcombe, Ian Brierley
Jan 22, 2016
Maturation of selected human mitochondrial tRNAs requires deadenylation
SF Pearce, J Rorbach, L van Haute, AR D'Souza, P Rebelo-Guiomar, CA Powell, I Brierley, AE Firth, M Minczuk
Sep 26, 2017
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jul 30, 2021
Background
Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the...
genetic variation cardiac hypertrophy complex disease ribosome biogenesis ribosome profiling ribosomopathy Translational efficiency Spontaneously hypertensive rats (SHR) HXB/BXH rat recombinant inbred panel trans QTL mapping
Published by: Genome biology
General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Eukaryotes respond to amino acid starvation by enhancing the translation of mRNAs encoding b-ZIP family transcription factors (GCN4 in Saccharomyces cerevisiae and ATF4 in mammals), which launch transcriptional programs to...
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jun 28, 2021
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jul 02, 2021
BACKGROUND: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of...
cardiac hypertrophy complex disease genetic variation HXB/BXH rat recombinant inbred panel ribosome biogenesis ribosome profiling ribosomopathy Spontaneously hypertensive rats (SHR) Translational efficiency trans QTL mapping Animals Cardiomegaly Gene Expression Profiling Gene Expression Regulation genetic variation Male Mice Mice Inbred C57BL Mice Knockout Myocardium Organelle Biogenesis Peptide Chain Initiation Translational Quantitative Trait Loci RNA Messenger RNA Small Nucleolar Rats Rats Inbred SHR Rats Transgenic Ribosomal Proteins Ribosomes Saccharomyces cerevisiae Sarcomeres
Comparative Analysis of Gene Expression in Virulent and Attenuated Strains of Infectious Bronchitis Virus at Subcodon Resolution.
RNA virus RNASeq avian coronavirus differential gene expression ribosome profiling Translation Animals Chickens Codon Coronavirus Infections Frameshifting Ribosomal Gene Expression Gene Expression Profiling Gene Expression Regulation Viral Infectious bronchitis virus Open Reading Frames Poultry Diseases RNA Messenger RNA Viral Ribosomes Transcriptome Virulence Exome Sequencing
Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
Georgia Cook, Katherine Brown, Pengcheng Shang, Yanhua Li, Lior Soday, Adam Dinan, Charlotte Tumescheit, Adrian Mockett, Ying Fang, Andrew Firth, Ian Brierley
Apr 11, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus which causes significant economic losses to the swine industry worldwide. Here, we use ribosome profiling (RiboSeq) and parallel RNA sequencing...
PRRSV RNA sequencing arterivirus Chromosomes Gene Expression Gene Expression Regulation infectious disease microbiology nidovirus porcine reproductive programmed ribosomal frameshifting respiratory syndrome virus ribosome profiling subgenomic mRNAs Transcriptome translatome Animals Codon Frameshifting Ribosomal Gene Expression Profiling Porcine respiratory and reproductive syndrome virus Ribosomes Swine Transcriptome