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Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects.
Ramya Lakshminarayan, Ben P Phillips, Imogen L Binnian, Natalia Gomez-Navarro, Norberto Escudero-Urquijo, Alan J Warren, Elizabeth A Miller
Jan 29, 2020
Cells possess multiple mechanisms that protect against the accumulation of toxic aggregation-prone proteins. Here, we identify a pre-emptive pathway that reduces synthesis of membrane proteins that have failed to properly...