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Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts.
Y Zhang, L Guzadhur, K Jeevaratnam, SC Salvage, GDK Matthews, WJ Lammers, M Lei, CL-H Huang, JA Fraser
Jul 03, 2020
AIM: To test a hypothesis attributing arrhythmia in Brugada Syndrome to right ventricular (RV) outflow tract (RVOT) conduction abnormalities arising from Nav 1.5 insufficiency and fibrotic change. METHODS: Arrhythmic properties...
Brugada Syndrome Na+ channel conduction velocity right ventricular outflow tract Action Potentials Animals Arrhythmias Cardiac Blotting Western Brugada Syndrome Disease Models Animal Electrophysiology Female Heart Heart Conduction System Male Mice Mice Mutant Strains NAV1.5 Voltage-Gated Sodium Channel Organ Culture Techniques