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The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model.
Alessandra Granata, Ioannis Kasioulis, Felipe Serrano, James D Cooper, Matthew Traylor, Sanjay Sinha, Hugh S Markus
Apr 13, 2022
A common variant in the Histone Deacetylase 9 (HDAC9) gene is the strongest genetic risk for large-vessel stroke, and HDAC9 offers a novel target for therapeutic modulation. However, the mechanisms linking the HDAC9 variant with...