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Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion.
Lina Ma, Jiawei Wu, Ying Zheng, Zimei Shu, Zhenquan Wei, Yinbiao Sun, Robin W Carrell, Aiwu Zhou
May 29, 2020
Kallistatin, also known as SERPINA4, has been implicated in the regulation of blood pressure and angiogenesis, due to its specific inhibition of tissue kallikrein 1 (KLK1) and/or by its heparin binding ability. The binding of...