Search
Results: 6
Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure.
Romain F Laine, Gemma Goodfellow, Laurence J Young, Jon Travers, Danielle Carroll, Oliver Dibben, Helen Bright, Clemens F Kaminski
Jan 02, 2019
Optical super-resolution microscopy techniques enable high molecular specificity with high spatial resolution and constitute a set of powerful tools in the investigation of the structure of supramolecular assemblies such as...
Influenza Newcastle disease virus EPIDEMIOLOGY Global Health infectious disease Machine Learning microbiology structural analysis super-resolution microscopy Virus Algorithms Automation Image Processing Computer-Assisted Influenza Vaccines Machine Learning Microscopy Fluorescence Newcastle disease virus Orthomyxoviridae vaccines Attenuated
Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors
Haiyan Cai, Parvathy Sasikumar, Gemma Little, Dominique Bihan, Samir W. Hamaia, Aiwu Zhou, Jonathan M. Gibbins, Richard W. Farndale
Jul 07, 2021
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of...
A base measure of precision for protein stability predictors
Abstract: Background: Prediction of the change in fold stability (ΔΔG) of a protein upon mutation is of major importance to protein engineering and screening of disease-causing variants. Many prediction methods can use 3D...
Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors.
Haiyan Cai, Parvathy Sasikumar, Gemma Little, Dominique Bihan, Samir W Hamaia, Aiwu Zhou, Jonathan M Gibbins, Richard W Farndale
Jul 01, 2021