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Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.
Andrew YF Li Yim, Enrico Ferrero, Klio Maratou, Huw D Lewis, George Royal, David F Tough, Chris Larminie, Marcel MAM Mannens, Peter Henneman, Wouter J de Jonge, Marleen GH van de Sande, Danielle M Gerlag, Rab K Prinjha, Paul P Tak
May 06, 2021
In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative...
DNA Methylation Arthralgia multi-omics analyses rheumatoid arthritis synovial biopsies target identification transcriptomics Adult Aged Aged 80 and over Arthralgia Arthritis Rheumatoid Arthroscopy Biopsy DNA Methylation Epigenesis Genetic Female Humans Male Middle Aged RNA-seq Severity of Illness Index Synovial Membrane whole genome sequencing Young Adult
Machine learning for target discovery in drug development.
Chemical probes Chemical proteomics Drug Discovery Machine Learning target identification Antineoplastic Agents Computer Simulation Drug Evaluation Preclinical Humans lipoxygenase Machine Learning Molecular Targeted Therapy Naphthoquinones Pentacyclic Triterpenes Proteomics Receptors Cannabinoid Sesquiterpenes Sesquiterpenes Guaiane Transient Receptor Potential Channels
Mouse models of colorectal cancer as preclinical models.
Target identification of $\textit{Mycobacterium tuberculosis phenotypic}$ hits using a concerted chemogenomic, biophysical and structural approach
G Mugumbate, V Silva E Costa Mendes, M Blaszczyk, M Sabbah, G Papadatos, J Lelievre, L Ballell, D Barros, C Abell, TL Blundell, JP Overington
Feb 02, 2018