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Proteolysis-targeting chimeras (PROTACs) that degrade disease-causing proteins by hijacking the endogenous ubiquitin-proteasome system have emerged as an exciting and transformative technology in both chemical biology and drug...

covalent ligands natural products Proteasome reversible covalent ligands targeted protein degradation Enzyme Inhibitors Humans Proteolysis Small Molecule Libraries Ubiquitin-Protein Ligases

E3s comprise a structurally diverse group of at least 800 members, most of which target multiple substrates through specific and regulated protein-protein interactions. These interactions typically rely on short linear motifs...

E3-substrate interaction SLiM degron multivalency targeted protein degradation ubiquitin ligase