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Hierarchical spectral clustering reveals brain size and shape changes in asymptomatic carriers of C9orf72.
Rose Bruffaerts, Dorothy Gors, Alicia Bárcenas Gallardo, Mathieu Vandenbulcke, Philip Van Damme, Paul Suetens, John C van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Alexandre de Mendonça, Fabrizio Tagliavini, Chris R Butler, Isabel Santana, Alexander Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Jonathan D Rohrer, Patrick Dupont, Peter Claes, Rik Vandenberghe, Genetic Frontotemporal dementia Initiative (GENFI)
Sep 02, 2022
Traditional methods for detecting asymptomatic brain changes in neurodegenerative diseases such as Alzheimer's disease or frontotemporal degeneration typically evaluate changes in volume at a predefined level of granularity...
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy.
MRI MRS Neurodegenerative disease tensor-based morphometry trinucleotide repeat disorders Animals Aspartic Acid Brain Disease Models Animal Disease Progression Glutamic Acid Humans Huntingtin Protein Huntington Disease Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mice Mice Transgenic Trinucleotide Repeats