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A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration.
DI Jodrell, A Bowman, R Rye, B Byrne, A Boddy, I Rafi, GA Taylor, A Johnston, NJ Clendeninn
Sep 02, 2020
2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug...
rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
Linda E Kelemen, Madalene Earp, Brooke L Fridley, Georgia Chenevix-Trench, Australian Ovarian Cancer Study Group, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Diether Lambrechts, Sandrina Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Mary Anne Rossing, Jennifer A Doherty, Jenny Chang-Claude, Sabine Behrens, Kirsten B Moysich, Rikki Cannioto, Shashikant Lele, Kunle Odunsi, Marc T Goodman, Yurii B Shvetsov, Pamela J Thompson, Lynne R Wilkens, Thilo Dörk, Natalia Antonenkova, Natalia Bogdanova, Peter Hillemanns, Ingo B Runnebaum, Andreas du Bois, Philipp Harter, Florian Heitz, Ira Schwaab, Ralf Butzow, Liisa M Pelttari, Heli Nevanlinna, Francesmary Modugno, Robert P Edwards, Joseph L Kelley, Roberta B Ness, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, Susanne K Kjaer, Allan Jensen, Julie M Cunningham, Robert A Vierkant, Graham G Giles, Fiona Bruinsma, Melissa C Southey, Michelle AT Hildebrandt, Dong Liang, Karen Lu, Xifeng Wu, Thomas A Sellers, Douglas A Levine, Joellen M Schildkraut, Edwin S Iversen, Kathryn L Terry, Daniel W Cramer, Shelley S Tworoger, Elizabeth M Poole, Elisa V Bandera, Sara H Olson, Irene Orlow, Liv Cecilie Vestrheim Thomsen, Line Bjorge, Camilla Krakstad, Ingvild L Tangen, Lambertus A Kiemeney, Katja KH Aben, Leon FAG Massuger, Anne M van Altena, Tanja Pejovic, Yukie Bean, Melissa Kellar, Linda S Cook, Nhu D Le, Angela Brooks-Wilson, Jacek Gronwald, Cezary Cybulski, Anna Jakubowska, Jan Lubiński, Nicolas Wentzensen, Louise A Brinton, Jolanta Lissowska, Estrid Hogdall, Svend Aage Engelholm, Claus Hogdall, Lene Lundvall, Lotte Nedergaard, Paul DP Pharoah, Ed Dicks, Honglin Song, Jonathan P Tyrer, Iain McNeish, Nadeem Siddiqui, Karen Carty, Rosalind Glasspool, James Paul, Ian G Campbell, Diana Eccles, Alice S Whittemore, Valerie McGuire, Joseph H Rothstein, Weiva Sieh, Steven A Narod, Catherine M Phelan, John R McLaughlin, Harvey A Risch, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Aleksandra Gentry-Maharaj, Susan J Ramus, Anna H Wu, Celeste Leigh Pearce, Alice W Lee, Malcolm C Pike, Jolanta Kupryjanczyk, Agnieszka Podgorska, Joanna Plisiecka-Halasa, Wlodzimierz Sawicki, Ellen L Goode, Andrew Berchuck, Ovarian Cancer Association Consortium
Nov 13, 2018
Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate...
consortia enolase superfamily member 1 expression quantitative trait locus Genetics gynecology Ovarian Neoplasms single-nucleotide polymorphism thymidylate synthase Adenocarcinoma Mucinous Case-Control Studies Female Gene Expression Regulation Neoplastic Genetic Association Studies Humans Hydro-Lyases Logistic Models Middle Aged Odds Ratio Ovarian Neoplasms Polymorphism Single Nucleotide Proteins Quantitative Trait Loci RNA Antisense risk Signal Transduction thymidylate synthase
DfrA-thyA double deletion in para-aminosalicylic acid resistant Mycobacterium tuberculosis Beijing strains
Danesh Moradigaravand, Louis Grandjean, Elena Martinez, Hao Li, Jun Zheng, Jorge Coronel, David Moore, M Estée Török, Vitali Sintchenko, Hairong Huang, Babak Javid, Julian Parkhill, Sharon J Peacock, Claudio U Köser
Mar 30, 2016
Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma.
NA Wong, L Brett, M Stewart, A Leitch, DB Longley, MG Dunlop, PG Johnston, AM Lessells, DI Jodrell
Sep 02, 2020
Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is inhibited by metabolites of the chemotherapeutic agent 5-fluorouracil (5FU). Nuclear expression of TS in human tissue in vivo has not been characterised and its...
Adenocarcinoma Adult Aged Antimetabolites Antineoplastic Cell Differentiation Cell Nucleus Colorectal Neoplasms Drug Resistance Neoplasm Enzyme Induction Enzyme Inhibitors Female Fluorouracil Gene Expression Profiling Genes p53 Humans Ki-67 Antigen Male Middle Aged Neoplasm Metastasis Neoplasm Proteins RNA Messenger RNA Neoplasm Reproducibility of Results Survival Analysis thymidylate synthase Treatment Outcome Tumor Suppressor Protein p53