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complex protein DNA-repair Network PATHWAY BRCA1 BRCA2/FANCD1 ORTHOLOG REVEALS ubiquitin ligase

Fbxo7 anaemia Cell Cycle DIFFERENTIATION mitophagy rs11107 ubiquitin ligase Anemia Animals Cell Cycle Checkpoints Cell Line Tumor Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation Erythrocytes Erythropoiesis F-Box Proteins Genotype Hemoglobins Mice Knockout Mitochondria Mitophagy Phenotype Protein Stability RNA Interference Signal Transduction Time Factors Transfection

E3s comprise a structurally diverse group of at least 800 members, most of which target multiple substrates through specific and regulated protein-protein interactions. These interactions typically rely on short linear motifs...

E3-substrate interaction SLiM degron multivalency targeted protein degradation ubiquitin ligase