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ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
ATF7IP H3K9me3 HUSH complex SETDB1 epigenetic silencing Heterochromatin histone methylation ubiquitin-mediated degradation Cell Nucleus Enzyme Stability Epigenesis Genetic Gene Deletion Gene Silencing HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Proteasome Endopeptidase Complex Protein Binding Protein Methyltransferases Proteolysis Repressor Proteins Transcription Factors Transcriptome