An entropic safety catch controls hepatitis C virus entry and antibody resistance.
Lenka Stejskal,
Mphatso D Kalemera,
Charlotte B Lewis,
Machaela Palor,
Lucas Walker,
Tina Daviter,
William D Lees,
David S Moss,
Myrto Kremyda-Vlachou,
Zisis Kozlakidis,
Giulia Gallo,
Dalan Bailey,
William Rosenberg,
christopher Illingworth,
Adrian J Shepherd,
Joe Grove
Jul 28, 2022
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2...