Search
Results: 95
Compulsivity and impulsivity traits linked to attenuated developmental frontstriatal myelination trajectories
Edward Bullmore, Peter Jones, Ian Goodyer, Tobias Hauser, Gabriel Ziegler, Ray Dolan, Peter Fonagy, Ulman Lindenberger, Michael Moutoussis
Feb 21, 2019
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Loes CA Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
Sep 05, 2018
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain...
cerebral small vessel diseases Diffusion tensor imaging Genetic Association Studies Humans white matter Adult Aged Biological Specimen Banks cerebral small vessel diseases Dementia Depression Depressive Disorder Major Diffusion Magnetic Resonance Imaging Female Genome-Wide Association Study Humans Male Middle Aged stroke United Kingdom white matter
A Hierarchical Watershed Model of Fluid Intelligence in Childhood and Adolescence.
Fluid intelligence is the capacity to solve novel problems in the absence of task-specific knowledge and is highly predictive of outcomes like educational attainment and psychopathology. Here, we modeled the neurocognitive...
Frontal networks in adults with autism spectrum disorder.
Marco Catani, Flavio Dell'Acqua, Sanja Budisavljevic, Henrietta Howells, Michel Thiebaut de Schotten, Seán Froudist-Walsh, Lucio D'Anna, Abigail Thompson, Stefano Sandrone, Edward T Bullmore, John Suckling, Simon Baron-Cohen, Michael V Lombardo, Sally J Wheelwright, Bhismadev Chakrabarti, Meng-Chuan Lai, Amber NV Ruigrok, Alexander Leemans, Christine Ecker, Mrc Aims Consortium, Michael C Craig, Declan GM Murphy
Aug 09, 2017
It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum...
Neurocognitive reorganization between crystallized intelligence, fluid intelligence and white matter microstructure in two age-heterogeneous developmental cohorts.
Ivan L Simpson-Kent, Delia Fuhrmann, Joe Bathelt, Jascha Achterberg, Gesa Sophia Borgeest, Rogier A Kievit
Mar 02, 2020
Despite the reliability of intelligence measures in predicting important life outcomes such as educational achievement and mortality, the exact configuration and neural correlates of cognitive abilities remain poorly understood...
white matter Fluid intelligence structural equation modelling Crystallized intelligence Neurocognitive reorganization
Published by: Developmental cognitive neuroscience
Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence.
DM Lisiecka, R Holt, R Tait, M Ford, M-C Lai, LR Chura, S Baron-Cohen, MD Spencer, J Suckling
Apr 14, 2015
Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.
Anke Bletsch, Tim Schäfer, Caroline Mann, Derek S Andrews, Eileen Daly, Maria Gudbrandsen, Amber NV Ruigrok, Robert Dallyn, Rafael Romero-Garcia, Meng-Chuan Lai, Michael V Lombardo, Michael C Craig, John Suckling, Edward T Bullmore, Simon Baron-Cohen, MRC AIMS Consortium, Declan GM Murphy, Flavio Dell'Acqua, Christine Ecker
Nov 09, 2020
Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently...
Post-acute blood biomarkers and disease progression in traumatic brain injury.
Virginia FJ Newcombe, Nicholas J Ashton, Jussi P Posti, Ben Glocker, Anne Manktelow, Doris A Chatfield, Stefan Winzeck, Edward Needham, Marta M Correia, Guy B Williams, Joel Simrén, Riikka SK Takala, Ari J Katila, Henna Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K Menon
Apr 07, 2022
There is substantial interest in the potential for traumatic brain injury to result in progressive neurological deterioration. While blood biomarkers such as glial fibrillary acid protein (GFAP) and neurofilament light have been...
White matter microstructure associations with episodic memory in adults with Down syndrome
Austin Bazydlo, Matthew Zammit, Minjie Wu, Douglas Dean, Sterling Johnson, Dana Tudorascu, Ann Cohen, Karly Cody, Beau Ances, Charles Laymon, William Klunk, Shahid Zaman, Benjamin Handen, Andrew Alexander, Bradley Christian, Sigan Hartley
May 26, 2021
BACKGROUND: Nearly all persons with Down syndrome will show pathology of Alzheimer's disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheimer's...
Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus
NC Keong, A Pena, SJ Price, M Czosnyka, Z Czosnyka, EE DeVito, CR Housden, BJ Sahakian, JD Pickard
Oct 06, 2017
Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter.
Juho M Strömmer, Simon W Davis, Richard N Henson, Lorraine K Tyler, Cam-CAN, Karen L Campbell
Dec 18, 2018
Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed...
brain aging cognitive decline Exercise Adolescent Adult Age Factors Aged Aged 80 and over aging ANISOTROPY Cognition Diffusion Magnetic Resonance Imaging England Exercise Female Frontal Lobe Humans Image Processing Computer-Assisted Male Middle Aged Psychomotor Performance Reaction Time Surveys and Questionnaires white matter
White matter microstructural abnormalities in children with severe congenital hypothyroidism.
Hannah E Cooper, Enrico Kaden, Lorna F Halliday, Doris-Eva Bamiou, Kshitij Mankad, Catherine Peters, Christopher A Clark
Oct 14, 2019
Working memory training and brain structure and function in extremely preterm or extremely low birth weight children.
Claire E Kelly, Deanne K Thompson, Jian Chen, Elisha K Josev, Leona Pascoe, Megan M Spencer-Smith, Chris Adamson, Chiara Nosarti, Susan Gathercole, Gehan Roberts, Katherine J Lee, Lex W Doyle, Marc L Seal, Peter J Anderson
Nov 15, 2019
This study in children born extremely preterm (EP; <28 weeks' gestational age) or extremely low birth weight (ELBW; <1,000 g) investigated whether adaptive working memory training using Cogmed® is associated with structural...
Cogmed diffusion imaging functional imaging Magnetic Resonance Imaging MICROSTRUCTURE Preterm birth Brain Mapping Child Cognitive Remediation Female Gyrus Cinguli Humans Infant Extremely Low Birth Weight Infant Extremely Premature Infant Newborn Magnetic Resonance Imaging Male Memory Short-Term Neuronal Plasticity Outcome Assessment Health Care Parietal Lobe practice Psychological white matter
Rate of, and risk factors for, white matter hyperintensity growth
BACKGROUND: White matter hyperintensities (WMHs) are a highly prevalent MRI marker of cerebral small vessel disease (SVD), which predict stroke and dementia risk, and are being increasingly used as a surrogate marker in clinical...
Cerebral Microbleeds and Structural White Matter Integrity in Patients With Traumatic Brain Injury-A Diffusion Tensor Imaging Study.
Juho Dahl, Olli Tenovuo, Jussi P Posti, Jussi Hirvonen, Ari J Katila, Janek Frantzén, Henna-Riikka Maanpää, Riikka Takala, Eliisa Löyttyniemi, Jussi Tallus, Virginia Newcombe, David K Menon, Peter J Hutchinson, Mehrbod Mohammadian
Jul 18, 2022
Diffuse axonal injury (DAI) is a common neuropathological manifestation of traumatic brain injury (TBI), presenting as traumatic alterations in the cerebral white matter (WM) microstructure and often leading to long-term...
Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab.
J William L Brown, Ferran Prados Carrasco, Arman Eshaghi, Carole H Sudre, Tom Button, Matteo Pardini, Rebecca S Samson, Sebastien Ourselin, Claudia Am Gandini Wheeler-Kingshott, Joanne L Jones, Alasdair J Coles, Declan T Chard
May 10, 2019
BACKGROUND: In multiple sclerosis (MS), disease effects on magnetisation transfer ratio (MTR) increase towards the ventricles. This periventricular gradient is evident shortly after first symptoms and is independent of white...
The neural determinants of age-related changes in fluid intelligence
Rogier A Kievit, Delia Fuhrmann, Gesa Sophia Borgeest, Ivan L Simpson-Kent, Richard NA Henson
Oct 05, 2018
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function...
Diffusion imaging in dementia with Lewy bodies
Paul C Donaghy, Michael Firbank, George Petrides, Jim Lloyd, Nicola Barnett, Kirsty Olsen, Alan J Thomas, John T O'Brien
Jul 29, 2020
INTRODUCTION: White matter disruption in dementia has been linked to a variety of factors including vascular disease and cortical pathology. We aimed to examine the relationship between white matter changes on diffusion tensor...
Amyloid dementia with Lewy bodies Diffusion tensor imaging vascular white matter Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Aniline Compounds Atrophy Cerebrovascular Disorders Diffusion tensor imaging Ethylene Glycols Female Gray Matter Hippocampus Humans Lewy Body Disease Male Positron-Emission Tomography Prospective Studies white matter
White matter hyperintensities are seen only inGRNmutation carriers in the GENFI cohort.
Carole H Sudre, Martina Bocchetta, David Cash, David L Thomas, Ione Woollacott, Katrina M Dick, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Sébastien Ourselin, M Jorge Cardoso, Jonathan D Rohrer, GENFI Genetic FTD Initiative
Nov 23, 2017
Genetic frontotemporal dementia is most commonly caused by mutations in the progranulin(GRN), microtubule-associated protein tau (MAPT)and chromosome 9 open reading frame 72(C9orf72) genes. Previous small studies have reported...
CI Confidence interval FTD Frontotemporal dementia IQR Inter Quartile Range PS Presymptomatic S Symptomatic TIV Total Intracranial volume WMH White matter hyperintensity Adult Aged C9orf72 Protein Cohort Studies Female frontotemporal dementia Humans Intercellular Signaling Peptides and Proteins Magnetic Resonance Imaging Male Middle Aged white matter tau Proteins
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells
How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults.
OBJECTIVES: To examine age-related differences in self-reported sleep quality and their associations with health outcomes across four domains: physical health, cognitive health, mental health and neural health. SETTING...
Ageing Cognition Healthy ageing Mental Health physical health sleep quality white matter Adolescent Adult Age Factors Aged Aged 80 and over ANISOTROPY Bayes Theorem Cognition Female health status Humans Male Mental Health Middle Aged prevalence Sleep Sleep Wake Disorders United Kingdom white matter Young Adult
|
|< |
< |
1 |