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Results: 4173
Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury
Anatole Harrois, James R Anstey, Mathieu van der Jagt, Fabio S Taccone, Andrew A Udy, Giuseppe Citerio, Jacques Duranteau, Carole Ichai, Rafael Badenes, John R Prowle, Ari Ercole, Mauro Oddo, Antoine Schneider, Stefan Wolf, Raimund Helbok, David W Nelson, D Jamie Cooper, Rinaldo Bellomo, TBI Collaborative
Sep 18, 2020
BACKGROUND/OBJECTIVE: Dysnatremia is common in severe traumatic brain injury (TBI) patients and may contribute to mortality. However, serum sodium variability has not been studied in TBI patients. We hypothesized that such...
Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.
Bjorn Bakker, Aaron Taudt, Mirjam E Belderbos, David Porubsky, Diana CJ Spierings, Tristan V de Jong, Nancy Halsema, Hinke G Kazemier, Karina Hoekstra-Wakker, Allan Bradley, Eveline SJM de Bont, Anke van den Berg, Victor Guryev, Peter M Lansdorp, Maria Colomé-Tatché, Floris Foijer
Oct 14, 2020
BACKGROUND: Chromosome instability leads to aneuploidy, a state in which cells have abnormal numbers of chromosomes, and is found in two out of three cancers. In a chromosomal instable p53 deficient mouse model with accelerated...
Aneuploidy Copy number detection karyotype heterogeneity leukaemia Lymphoma Single-cell sequencing Aneuploidy Animals chromosomal instability Chromosome Aberrations Comparative Genomic Hybridization Computational Biology DNA Copy Number Variations Genetic Heterogeneity Humans Karyotype Mice Mice Knockout Neoplasms Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Single-Cell Analysis Software
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Mar 03, 2021
Abstract: Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning...
Role of DNA-detection-based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials.
Admission Levels of Interleukin 10 and Amyloid β 1–40 Improve the Outcome Prediction Performance of the Helsinki Computed Tomography Score in Traumatic Brain Injury
Jussi P. Posti, Riikka S. K. Takala, Rahul Raj, Teemu M. Luoto, Leire Azurmendi, Linnéa Lagerstedt, Mehrbod Mohammadian, Iftakher Hossain, Jessica Gill, Janek Frantzén, Mark van Gils, Peter J. Hutchinson, Ari J. Katila, Pia Koivikko, Henna-Riikka Maanpää, David K. Menon, Virginia F. Newcombe, Jussi Tallus, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, Jean-Charles Sanchez
Nov 13, 2020
Background: Blood biomarkers may enhance outcome prediction performance of head computed tomography scores in traumatic brain injury (TBI). Objective: To investigate whether admission levels of eight different protein biomarkers...
Elicitation of expert prior opinion
Lisa V Hampson, John Whitehead, Despina Eleftheriou, Catrin Tudur-Smith, Rachel Jones, David Jayne, Helen Hickey, Michael W Beresford, Claudia Bracaglia, Afonso Caldas, Rolando Cimaz, Joke Dehoorne, Pavla Dolezalova, Mark Friswell, Marija Jelusic, Stephen D Marks, Neil Martin, Anne-Marie McMahon, Joachim Peitz, Annet van Royen-Kerkhof, Oguz Soylemezoglu, Paul A Brogan
Nov 24, 2020
OBJECTIVES: Definitive sample sizes for clinical trials in rare diseases are usually infeasible. Bayesian methodology can be used to maximise what is learnt from clinical trials in these circumstances. We elicited expert prior...
Identification and functional modelling of plausibly causative cis -regulatory variants in a highly-selected cohort with X-linked intellectual disability
Hemant Bengani, Detelina Grozeva, Lambert Moyon, Shipra Bhatia, Susana R. Louros, Jilly Hope, Adam Jackson, James G. Prendergast, Liusaidh J. Owen, Magali Naville, Jacqueline Rainger, Graeme Grimes, Mihail Halachev, Laura C. Murphy, Olivera Spasic-Boskovic, Veronica van Heyningen, Peter Kind, Catherine M. Abbott, Emily Osterweil, F. Lucy Raymond, Hugues Roest Crollius, David R. FitzPatrick
Aug 13, 2021
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikołaj Słabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter JM Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell
Sep 01, 2021
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants...
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
E. Madissoon, A. Wilbrey-Clark, R. J. Miragaia, K. Saeb-Parsy, K. T. Mahbubani, N. Georgakopoulos, P. Harding, K. Polanski, N. Huang, K. Nowicki-Osuch, R. C. Fitzgerald, K. W. Loudon, J. R. Ferdinand, M. R. Clatworthy, A. Tsingene, S. van Dongen, M. Dabrowska, M. Patel, M. J. T. Stubbington, S. A. Teichmann, O. Stegle, K. B. Meyer
Jun 06, 2020
Abstract: Background: The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas....
Simulating lattice gauge theories within quantum technologies
Mari Carmen Bañuls, Rainer Blatt, Jacopo Catani, Alessio Celi, Juan Ignacio Cirac, Marcello Dalmonte, Leonardo Fallani, Karl Jansen, Maciej Lewenstein, Simone Montangero, Christine A. Muschik, Benni Reznik, Enrique Rico, Luca Tagliacozzo, Karel Van Acoleyen, Frank Verstraete, Uwe-Jens Wiese, Matthew Wingate, Jakub Zakrzewski, Peter Zoller
Aug 11, 2021
Abstract: Lattice gauge theories, which originated from particle physics in the context of Quantum Chromodynamics (QCD), provide an important intellectual stimulus to further develop quantum information technologies. While one...
Biodiversity conservation as a promising frontier for behavioural science.
Kristian Steensen Nielsen, Theresa M Marteau, Jan M Bauer, Richard B Bradbury, Steven Broad, Gayle Burgess, Mark Burgman, Hilary Byerly, Susan Clayton, Dulce Espelosin, Paul J Ferraro, Brendan Fisher, Emma E Garnett, Julia PG Jones, Mark Otieno, Stephen Polasky, Taylor H Ricketts, Rosie Trevelyan, Sander van der Linden, Diogo Veríssimo, Andrew Balmford
Apr 08, 2021
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care
Aikaterini Kassavou, Venus Mirzaei, Sonia Shpendi, James Brimicombe, Jagmohan Chauhan, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Helen Eborall, Miranda Van Emmenis, Anna De Simoni, Amrit Takhar, Pankaj Gupta, Prashanth Patel, Cecilia Mascolo, Andrew Toby Prevost, Stephen Morris, Simon Griffin, Richard J McManus, Jonathan Mant, Stephen Sutton
Apr 09, 2021
Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.
Yohana C Toner, Adam A Ghotbi, Sonum Naidu, Ken Sakurai, Mandy MT van Leent, Stefan Jordan, Farideh Ordikhani, Letizia Amadori, Alexandros Marios Sofias, Elizabeth L Fisher, Alexander Maier, Nathaniel Sullivan, Jazz Munitz, Max L Senders, Christian Mason, Thomas Reiner, Georgios Soultanidis, Jason M Tarkin, James HF Rudd, Chiara Giannarelli, Jordi Ochando, Carlos Pérez-Medina, Andreas Kjaer, Willem JM Mulder, Zahi A Fayad, Claudia Calcagno
May 15, 2022
Digital delivery of behavioural activation therapy to overcome depression and facilitate social and economic transitions of adolescents in South Africa (the DoBAt study)
Bianca D Moffett, Julia R Pozuelo, Alastair van Heerden, Heather A O'Mahen, Michelle Craske, Tholene Sodi, Crick Lund, Kate Orkin, Emma J Kilford, Sarah-Jayne Blakemore, Mahreen Mahmud, Eustasius Musenge, Meghan Davis, Zamakhanya Makhanya, Tlangelani Baloyi, Daniel Mahlangu, Gabriele Chierchia, Sophie L Fielmann, F Xavier Gómez-Olivé, Imraan Valodia, Stephen Tollman, Kathleen Kahn, Alan Stein
Jan 05, 2023
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
Janice M Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J Mummery, Blossom CM Stephan, Daniele Altomare, Giovanni B Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J Llewellyn, European Task Force for Brain Health Services
Nov 22, 2021
We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the...
The Grizzly, November 12, 1991
Eric Foellmer, Megan Mendte, Erika Compton, Judd Woytek, Charles Washington, Tom Wilusz, Dana Kushwara, Kristin White, Julio Omana, Dave Van, Eric Bleickardt, Naimish Pandya, Gar Donecker, Erik Moore, Melisa Miller, Richard P. Richter, Steven Grubb, Harley David Rubin, Nick Baccino, Dawn Warner, Kris Wagner, Laura Zobel, Claire A Erfle, Jeff Brown, Laura Lecrone, John Ronning, Ronald E. Hess, Regina Oboler
Jan 01, 0001
Evaluations Show Drop in Pledge Grades SAC Changes to AFAC Voters Choose Wofford Tri-Lamba Meets Salk to Speak on Founders' Day Haley Visits Nearby High School "Crucible" Captivates WVOU at Music Marathon Environmental...
Ursinus College Collegeville Pennsylvania newspaper field hockey Swimming Al Angelos cross country Football Inter-Fraternity Council Gay and Lesbian Alliance Harris Wofford Roger P. Staiger pledging campus sculptures ProTheatre WVOU radio station campus security Greenhouse Effect Alex Haley Jonas Salk Donna Van Dusen student activities cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Methods for biogeochemical studies of sea ice
LA Miller, F Fripiat, BGT Else, JS Bowman, KA Brown, RE Collins, M Ewert, A Fransson, M Gosselin, D Lannuzel, KM Meiners, C Michel, J Nishioka, D Nomura, S Papadimitriou, LM Russell, LL Sørensen, DN Thomas, JL Tison, MA Van Leeuwe, M Vancoppenolle, EW Wolff, J Zhou
Mar 19, 2015
Prescribing of antidiabetic medicines before, during and after pregnancy
Rachel Charlton, K Klungsoyr, Amanda Neville, Sue Jordan, Lolkje de Jong-van den Berg, H Bos, A Puccini, A Engeland, R Gini, G Davies, A Hansen, H Wang, Anita McGrogan, A Andersen, Helen Dolk, E Garne, Anna Pierini
May 18, 2016
Aim: To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe.
Methods: A common protocol was implemented across seven databases in Denmark, Norway, The...
Methods: A common protocol was implemented across seven databases in Denmark, Norway, The...
Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis
J B Lilleker, A Rietveld, S R Pye, K Mariampillai, O Benveniste, M T J Peeters, J A L Miller, M G Hanna, P M Machado, M J Parton, K R Gheorghe, U A Badrising, I E Lundberg, S Sacconi, M K Herbert, N J McHugh, B R F Lecky, C Brierley, D Hilton-Jones, J A Lamb, M E Roberts, R G Cooper, C G J Saris, G J M Pruijn, H Chinoy, B G M van Engelen
May 01, 2017
OBJECTIVES: Autoantibodies directed against cytosolic 5'-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study investigated the association between anticytosolic...
Patterns of gray matter atrophy in genetic frontotemporal dementia
David M Cash, Martina Bocchetta, David L Thomas, Katrina M Dick, John C van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Martin N Rossor, Sebastien Ourselin, Jonathan D Rohrer, GENFI, Genetic FTD Initiative
Feb 05, 2018
Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms of genetic FTD...
Enantiomeric profiling of chiral illicit drugs in a pan-European study
Erika Castrignano, Zhugen Yang, Richard Bade, Jose A. Baz-Lomba, Sara Castiglioni, Ana Causanilles, Adrian Covaci, Emma Gracia-Lor, Felix Hernandez, Juliet Kinyua, Ann-Kathrin McCall, Alexander L. N. van Nuijs, Christoph Ort, Benedek Plosz, Pedram Ramin, Nikolaos I. Rousis, Yeonsuk Ryu, Kevin V. Thomas, Pim de Voogt, Ettore Zuccato, Barbara Kasprzyk-Hordern
Mar 01, 2018
The aim of this paper is to present the first study on spatial and temporal variation in the enantiomeric profile of chiral drugs in eight European cities. Wastewater-based epidemiology (WBE) and enantioselective analysis were...
Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48).
Jennifer Hirst, Marianna Madeo, Katrien Smets, James R Edgar, Ludger Schols, Jun Li, Anna Yarrow, Tine Deconinck, Jonathan Baets, Elisabeth Van Aken, Jan De Bleecker, Manuel B Datiles, Ricardo H Roda, Joachim Liepert, Stephan Züchner, Caterina Mariotti, Peter De Jonghe, Craig Blackstone, Michael C Kruer
Dec 19, 2018
OBJECTIVE: Biallelic mutations in the AP5Z1 gene encoding the AP-5 ζ subunit have been described in a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype-phenotype correlations...
Electron acceleration above thunderclouds
M Fullekrug, I Kolmasova, O Santolik, T Farges, J Bor, A J Bennett, M Parrot, M Rison, F Zanotti, E Arnone, A Mezentsev, R Lan, L Uhlir, Giles Harrison, S Soula, O A van der Velde, J-L Pincon, C. Helling, D. Diver
Jul 01, 2013
The acceleration of electrons results in observable electromagnetic waves which can be used for remote sensing. Here, we make use of ∼4 Hz-66 MHz radio waves emitted by two consecutive intense positive lightning discharges to...
Substituting prolonged sedentary time and cardiovascular risk in children and youth
Katrien Wijndaele, Thomas White, Lars Bo Andersen, Anna Bugge, Elin Kolle, Kate Northstone, Niels Wedderkopp, Mathias Ried-Larsen, Susi Kriemler, Angie S Page, Jardena J Puder, John J Reilly, Luis B Sardinha, Esther Mf van Sluijs, Stephen J Sharp, Søren Brage, Ulf Ekelund, International Children’s Accelerometry Database (ICAD) Collaborators
Oct 10, 2019
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