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Uncertainty Quantification of the Effects of Blade Damage on the Actual Energy Production of Modern Wind Turbines
Francesco Papi, Lorenzo Capugi, Simone Salvadori, Mauro Carnevale, Alessandro Bianchini
Jul 23, 2020
Wind turbine blade deterioration issues have come to the attention of researchers and manufacturers due to the relevant impact they can have on the actual annual energy production (AEP). Research has shown how after prolonged...
Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease.
Prion diseases are fatal transmissible neurodegenerative conditions of humans and animals that arise through neurotoxicity induced by PrP misfolding. The cellular and molecular mechanisms of prion-induced neurotoxicity remain...
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD)
Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Huntington’s disease (HD) and as such are a target for therapeutic intervention, especially for the treatment of chorea and some...
Published by: BMJ Publishing Group
Frameworks for supporting patient and public involvement in research
Trisha Greenhalgh, Lisa Hinton, Teresa Finlay, Alastair Macfarlane, Nick Fahy, Ben Clyde, Alan Chant
Mar 09, 2020
BACKGROUND: Numerous frameworks for supporting, evaluating and reporting patient and public involvement in research exist. The literature is diverse and theoretically heterogeneous. OBJECTIVES: To identify and synthesize...
Impact of bowel preparation with Fleet's™ enema on prostate MRI quality.
Mehmet Coskun, Sherif Mehralivand, Joanna H Shih, Maria J Merino, Bradford J Wood, Peter A Pinto, Tristan Barrett, Peter L Choyke, Baris Turkbey
Apr 01, 2020
AIM: To investigate the effects of cleansing Fleet's™ enema (FE) on rectal distention and image quality of diffusion-weighted imaging (DWI) in prostate magnetic resonance imaging (MRI). METHODS: This study included 117...
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.
Siddhartha P Kar, Irene L Andrulis, Hermann Brenner, Stephen Burgess, Jenny Chang-Claude, Daniel Considine, Thilo Dörk, Dafydd Gareth R Evans, Manuela Gago-Domínguez, Graham G Giles, Mikael Hartman, Dezheng Huo, Rudolf Kaaks, Jingmei Li, Artitaya Lophatananon, Sara Margolin, Roger L Milne, Kenneth R Muir, Håkan Olsson, Kevin Punie, Paolo Radice, Jacques Simard, Rulla M Tamimi, Els Van Nieuwenhuysen, Camilla Wendt, Wei Zheng, Paul DP Pharoah
Feb 08, 2019
Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is...
Patient-Centered Outcomes From Multiparametric MRI and MRI-Guided Biopsy for Prostate Cancer
OBJECTIVE: To identify and characterize patient-centered outcomes (PCOs) relating to multiparametric MRI (mpMRI) and MRI-guided biopsy as diagnostic tests for possible prostate cancer. METHODS: Medline via OVID, EMBASE...
18F-FDG PET/CT Is an Early Predictor of Pathologic Tumor Response and Survival to Preoperative Radiochemotherapy with Bevacizumab in High Risk Locally Advanced Rectal Cancer.
Antonio Avallone, Luigi Aloj, Biagio Pecori, Corradina Caraco, Alfonso De Stefano, Fabiana Tatangelo, Lucrezia Silvestro, Vincenza Granata, Francesco Bianco, Carmela Romano, Francesca Di Gennaro, Alfredo Budillon, Antonella Petrillo, Paolo Muto, Gerardo Botti, Paolo Delrio, Secondo Lastoria
Oct 18, 2019
There is an unmet need for predictive biomarkers of the clinical benefit of anti-angiogenic drugs.The aim of the present study was to prospectively evaluate the value of FDG-PET/CT performed during and after preoperative...
Piezoresistivity and piezopermittivity of cement-based sensors under quasi-static stress and changing moisture
Jiacheng Zhang, Andrew Heath, Richard Ball, Binling Chen, Linzhen Tan, Guisheng Li, Jingbang Pan, Tugce Busra Su-Cadirci, Kevin Paine
Apr 26, 2024
Integrated cement-based sensors offer an economic alternative to extrinsic sensors for health monitoring applications in concrete structures due to their high strength to cost ratio, geometrical versatility, low shrinkage, and...
Gold Nanoparticles
A general procedure to prepare gold nanourchins (GNUs) via a seed-mediated method was followed using dopamine hydrochloride as a reducing agent and silver nitrate salt (AgNO3) as a shape-directing agent. The novelty...
Life on the edge
Invasive non-native species (INNS) with marine or brackish origins have become increasingly common occupying freshwater habitats. The transition of INNS from marine or brackish water into physiologically stressful freshwater...
Guidelines for Industrial Symbiosis—a Systematic Approach for Content Definition and Practical Recommendations for Implementation
Abstract The increase of industrial symbiosis (IS) activities around the world has strongly contributed to promote awareness among companies on the benefits of this business model and...
João Azevedo, Juan Henriques, Marco Estrela, Rui Dias, Doroteya Vladimirova, Karen Miller, Muriel Iten
Sep 23, 2021
Self-reported physical functional health predicts future bone mineral density in EPIC-Norfolk cohort.
Sarah Perrott, Kathryn Martin, Victoria L Keevil, Nicholas J Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Feb 28, 2022
Using a large population sample from the UK, we found that self-reported physical functional health may be used to predict future bone mineral density especially in women. It may be a useful and inexpensive way to identify...
Tumor suppressors inhibit reprogramming of African spiny mouse ( Acomys) fibroblasts to induced pluripotent stem cells.
Background: The African spiny mouse ( Acomys) is an emerging mammalian model for scar-free regeneration, and further study of Acomys could advance the field of regenerative medicine. Isolation of pluripotent stem cells from...
Accuracy of Optic Nerve Sheath Diameter Measurements in Pocket-Sized Ultrasound Devices in a Simulation Model.
Garrett GRJ Johnson, Tomislav Jelic, Angela Derksen, Bertram Unger, Frederick A Zeiler, Markus T Ziesmann, Lawrence M Gillman
Apr 20, 2022
INTRODUCTION: Transorbital sonographic measurement of optic nerve sheath diameter (ONSD) is an emerging non-invasive technique for the identification and monitoring of intracranial hypertension. In recent years, new pocket...
A theoretical analysis of taxonomic binning accuracy.
Many metagenomic and environmental DNA studies require the taxonomic assignment of individual reads or sequences by aligning reads to a reference database, known as taxonomic binning. When a read aligns to more than one...
Post hoc validation of a tool that accurately predicts the outcome of endoscopic therapy in Bouveret syndrome.
BACKGROUND: Bouveret syndrome is characterized by gallstone impaction in the upper gastrointestinal tract causing gastric outlet obstruction. In Bouveret syndrome, endoscopic gallstone removal can avert the need for surgery....
Co-designing an intervention to increase uptake of advance care planning in later life following emergency hospitalisation
INTRODUCTION: Despite the potential benefits of advance care planning, uptake in older adults is low. In general, there is a lack of guidance as to how to initiate advance care planning conversations and encourage individuals to...
Emergency care for older people living with frailty
Background Little is known about how frailty impacts on older people’s experiences of emergency care, despite patient experience being essential to providing person-centred care. This...
Emma Regen, Kay Phelps, James David van Oppen, Peter Riley, Jagruti Lalseta, Graham Martin, Suzanne M Mason, Simon Conroy
Aug 22, 2022
Parenting roles for young people with attention-deficit/hyperactivity disorder transitioning to adult services.
AIM: To inform transitions from child to adult health services, we explored the work and roles parents take in the care of young people with attention-deficit/hyperactivity disorder (ADHD) aged 14 to 25 years old. METHOD: Using...
Incidence and predictive factors of problems after fixation of trochanteric hip fractures with sliding hip screw or intramedullary devices
Piers Page, M Field, N Vetharajan, A Smith, L Duggleby, Dario Cazzola, Michael Whitehouse, Richie Gill
Jul 01, 2022
Introduction: Hip fractures are common and disabling injuries, usually managed surgically. The most common type outside the joint capsule are trochanteric fractures, usually fixed with either sliding hip screw or...
Estimating the prevalence of problem drug use from drug-related mortality data.
Hayley E Jones, Ross J Harris, Beatrice C Downing, Matthias Pierce, Tim Millar, AE Ades, Nicky J Welton, Anne M Presanis, Daniela De Angelis, Matthew Hickman
Aug 26, 2020
BACKGROUND AND AIMS: Indirect estimation methods are required for estimating the size of populations where only a proportion of individuals are observed directly, such as problem drug users (PDUs). Capture-recapture and...
Applying multi-temporal landsat satellite data and markov-cellular automata to predict forest cover change and forest degradation of sundarban reserve forest, Bangladesh
Overdependence on and exploitation of forest resources have significantly transformed the natural reserve forest of Sundarban, which shares the largest mangrove territory in the world, into a great degradation status. By...
ME Hasan, B Nath, AHMR Sarker, Z Wang, L Zhang, X Yang, MN Nobi, E Røskaft, DJ Chivers, M Suza
Sep 22, 2020
Brief screening for maternal mental health in Vietnam
HP Do, PR Baker, TV Vo, BY Luong-Thanh, LH Nguyen, S Valdebenito, M Eisner, BX Tran, TD Hoang, MP Dunne
Jan 18, 2021
Background: In many countries, there is limited consideration of the psychological wellbeing of women during antenatal and postnatal care. Among a range of contributing factors, one practical reason is that brief, valid and...
Integration of proteomics with CT-based qualitative and radiomic features in high-grade serous ovarian cancer patients
Lucian Beer, Hilal Sahin, Nicholas W. Bateman, Ivana Blazic, Hebert Alberto Vargas, Harini Veeraraghavan, Justin Kirby, Brenda Fevrier-Sullivan, John B. Freymann, C. Carl Jaffe, James Brenton, Maura Miccó, Stephanie Nougaret, Kathleen M. Darcy, G. Larry Maxwell, Thomas P. Conrads, Erich Huang, Evis Sala
Apr 06, 2021
Abstract: Objectives: To investigate the association between CT imaging traits and texture metrics with proteomic data in patients with high-grade serous ovarian cancer (HGSOC). Methods: This retrospective, hypothesis-generating...
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