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Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016
Nicholas Steel, John A. Ford, John N. Newton, Adrian C.J. Davis, Theo Vos, Mohsen Naghavi, Scott Glenn, Andrew Hughes, Alice M. Dalton, Diane Stockton, Ciaran Humphreys, Mary Dallat, Jürgen Schmidt, Julian Flowers, Sebastian Fox, Ibrahim Abubakar, Robert W. Aldridge, Allan Baker, Carol Brayne, Traolach Brugha, Simon Capewell, Josip Car, Cyrus Cooper, Majid Ezzati, Justine Fitzpatrick, Felix Greaves, Roderick Hay, Simon Hay, Frank Kee, Heidi J. Larson, Ronan A. Lyons, Azeem Majeed, Martin McKee, Salman Rawaf, Harry Rutter, Sonia Saxena, Aziz Sheikh, Liam Smeeth, Russell M. Viner, Stein Emil Vollset, Hywel C. Williams, Charles Wolfe, Anthony Woolf, Christopher J.L. Murray
Nov 03, 2018
Background: Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable...
A zebrafish model for Mycobacterium leprae granulomatous infection
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at ~30°C, so we sought to model...
Wood-a 45th anniversary review of JMS papers. Part 1
Martin P Ansell
Dec 01, 2011
The first part of a comprehensive review of the literature on wood published in the Journal of Materials Science since its inception in 1966 is presented. Papers are reviewed by subject ranging from the determination of the...
The opposite end of the attention deficit hyperactivity disorder (ADHD) continuum
Corina U. Greven, Andrew Merwood, Jolanda M J van der Meer, Claire M. A. Haworth, Nanda Rommelse, Jan K. Buitelaar
Apr 01, 2016
Background: Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high...
The Grizzly, February 24, 2005
Lauren A. Perotti, Lindsey Fund, Megan Helzner, Jenn McCann, Kristin Carter, Matthew Pastor, Christine Vanselous, Toyna Towles, Michael Graham, Matt Krolikowski, Matthew Jost, Dave Marcheskie
Jan 01, 0001
Spring Break Closing Information Board of Trustees Meet to Discuss Issues on Campus Fundraising Facts: Numbers Increase for Airband and Tsunami Relief Effort Negro Spirituals Celebrate Black History Month The Face in the...
Ursinus College Collegeville Pennsylvania newspaper wrestling Basketball tsunami Kelly Ireland theater Philip Zwerling Airband Board of Trustees cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Clinical and pathological associations of PTEN expression in ovarian cancer
Filipe Correia Martins, Dominique-Laurent Couturier, Anna Paterson, Anthony N. Karnezis, Christine Chow, Tayyebeh M. Nazeran, Adekunle Odunsi, Aleksandra Gentry-Maharaj, Aleksandra Vrvilo, Alexander Hein, Aline Talhouk, Ana Osorio, Andreas D. Hartkopf, Angela Brooks-Wilson, Anna DeFazio, Anna Fischer, Arndt Hartmann, Brenda Y. Hernandez, Bryan M. McCauley, Chloe Karpinskyj, Christiani B. de Sousa, Claus Høgdall, Daniel G. Tiezzi, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gary Keeney, Gregg Nelson, Helen Steed, Honglin Song, Hugh Luk, Javier Benitez, Jennifer Alsop, Jennifer M. Koziak, Jenny Lester, Joseph H. Rothstein, Jurandyr M. de Andrade, Lene Lundvall, Luis Paz-Ares, Luis Robles-Díaz, Lynne R. Wilkens, Maria J. Garcia, Maria P. Intermaggio, Marie-Lyne Alcaraz, Mary A. Brett, Matthias W. Beckmann, Mercedes Jimenez-Linan, Michael Anglesio, Michael E. Carney, Michael Schneider, Nadia Traficante, Nadja Pejovic, Naveena Singh, Nhu Le, Peter Sinn, Prafull Ghatage, Ramona Erber, Robert Edwards, Robert Vierkant, Roberta B. Ness, Samuel Leung, Sandra Orsulic, Sara Y. Brucker, Scott H. Kaufmann, Sian Fereday, Simon Gayther, Stacey J. Winham, Stefan Kommoss, Tanja Pejovic, Teri A. Longacre, Valerie McGuire, Valerie Rhenius, Weiva Sieh, Yurii B. Shvetsov, Alice S. Whittemore, Annette Staebler, Beth Y. Karlan, Cristina Rodriguez-Antona, David D. Bowtell, Ellen L. Goode, Estrid Høgdall, Francisco J. Candido dos Reis, Jacek Gronwald, Jenny Chang-Claude, Kirsten B. Moysich, Linda E. Kelemen, Linda S. Cook, Marc T. Goodman, Peter A. Fasching, Robin Crawford, Suha Deen, Usha Menon, David G. Huntsman, Martin Köbel, Susan J. Ramus, Paul D. P. Pharoah, James D. Brenton
Jun 18, 2021
Abstract: Background: PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN...
The pathogenesis of mesothelioma is driven by a dysregulated translatome.
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodósio, Catherine Ficken, Maria Guerra Martin, Ruth V Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J Sansom, Daniel Murphy, Marion MacFarlane, John PC Le Quesne, Anne E Willis
Aug 18, 2021
Malignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally linked with asbestos exposure. The disease primarily results from loss of tumour suppressor gene function and there are no 'druggable'...
A Teaching Suggestion in the COVID-19 Disease Pandemic Period
The effect of the COVID-19 pandemic shows that schools must adapt new approaches in order to continue to provide teaching and learning at schools. To achieve this, students must be equipped to learn in a multifaceted...
Published by: IGI Global Scientific Publishing
The diurnal and semidiurnal tides over Ascension Island (° S, 14° W) and their interaction with the stratospheric quasi-biennial oscillation
Horizontal winds in the mesosphere have been measured over Ascension Island (8° S, 14° W) in the tropical mid-Atlantic region throughout the years 2002-2011. The observations were made by a very high frequency (VHF) meteor...
Factors determining human-to-human transmissibility of zoonotic pathogens via contact.
Mathilde Richard, Sascha Knauf, Philip Lawrence, Alison E Mather, Vincent J Munster, Marcel A Müller, Derek Smith, Thijs Kuiken
Jun 12, 2020
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and...
N-type organic electrochemical transistors with stability in water.
Alexander Giovannitti, Christian B Nielsen, Dan-Tiberiu Sbircea, Sahika Inal, Mary Donahue, Muhammad R Niazi, David A Hanifi, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
Mar 27, 2018
Organic electrochemical transistors (OECTs) are receiving significant attention due to their ability to efficiently transduce biological signals. A major limitation of this technology is that only p-type materials have been...
The essential role of complement in antibody-mediated resistance to Salmonella.
Omar Rossi, Chris Coward, Yun Shan Goh, Jill WC Claassens, Calman A MacLennan, Sjef J Verbeek, Pietro Mastroeni
Nov 13, 2018
Vaccines can serve as essential tools to prevent bacterial diseases via the induction of long-lasting IgG responses. The efficacy of such vaccines depends on the effector mechanisms triggered by IgG. The complement system and...
Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes.
Junchol Park, James W Phillips, Jian-Zhong Guo, Kathleen A Martin, Adam W Hantman, Joshua T Dudman
Apr 09, 2022
The interaction of descending neocortical outputs and subcortical premotor circuits is critical for shaping skilled movements. Two broad classes of motor cortical output projection neurons provide input to many subcortical motor...
The Grizzly, September 19, 1980
Thomas A. Reilly, Deborah Scimeca, Kevin O'Neill, Karen L. Reese, Jennifer Bassett, John Squire, Larry Muscarella, Howard Miller, Ross Schwalm, Christine Battle, Ann Edris, Elizabeth P. Harp, Barbara Foley, Carol A. Hykel, Kay Buckwalter, Pat Keenan, Susan Colaiezzi, Amy Angst, David Garner, J. Paul, II, Brian Ballard, Jean Morrison
Jan 01, 0001
Reagan, Anderson Leading Carter In Campus Poll Wismer Lunch Off to Optimistic Start Explosive Bomb Found At NMD College Van Policy Drastically Revised Campus Expands With Enrollment Bad Conditions Haunt New Women's Dorm ...
Ursinus College Collegeville Pennsylvania newspaper Ronald Reagan John Anderson Jimmy Carter Wismer dining hall New Men's Dorm Reimert Hall vandalism arson student government Transportation Commonwealth Hall 476 Main Street Hall Sturgis Hall 624 Main Street Hall Schaff Hall Myrin Library Elizabeth Geary Davison J. Houghton Kane enrollment Mark D. Davies Thompson-Gay Gymnasium Evening school Ron Baltz Ritter Center Meistersingers Yes WRUC radio sororities rushing Switchboard Theft Collegeville Police Robin Clouser Mark E. Reitz Bomberger Memorial Hall Soccer Intramural Sports cross country Football field hockey cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Sticky words? Towards a theory of rhetorical path dependency
DENNIS C GRUBE
Feb 16, 2018
Speech matters. Political actors are defined by what they say as much as by what they do but, with each rhetorical choice, they also narrow the range of rhetorical options open to them for the future. This paper examines the...
Non-Linear Frequency Noise Modulation in a Resonant MEMS Accelerometer
Resonant MEMS accelerometers offer the potential for very high resolution and wide bandwidth measurements over a large input dynamic range. The read-out is implemented by constructing an oscillator with the resonator as the...
What is a 'fair' price? Ethics as sensemaking
Whereas the deliberative democracy approach to ethics seeks to bridge universalist reason and contextual judgment to explain the emergence of intersubjective agreements, it remains unclear how these two are reconciled in...
Toward a computational structure for life cycle sustainability analysis
Purpose: A widely used theory of the computational structure of life cycle assessment (LCA) has been available for more than a decade. The case of environmental life cycle cost (LCC) is still less clear: even the recent Code of...
A mutational signature in gastric cancer suggests therapeutic strategies.
Ludmil B Alexandrov, Serena Nik-Zainal, Hoi Cheong Siu, Suet Yi Leung, Michael R Stratton
Nov 01, 2018
Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and...
Resonance tracking in a micromechanical device using phononic frequency combs.
Micro and nanomechanical resonators have been extensively researched in recent decades for applications to time and frequency references, as well as highly sensitive sensors. Conventionally, the operation of these resonant...
Tailoring Interleaflet Lipid Transfer with a DNA-based Synthetic Enzyme.
Lipid membranes, enveloping all living systems, are of crucial importance, and control over their structure and composition is a highly desirable functionality of artificial structures. However, the rational design of...
Evaluating Students' Experiences of a Weekly “Hour of Code”
In the winter semester of 2020 during a multimedia design and production class for pre-service teachers, the students were introduced to basic computer coding concepts such as variables, conditional statements, various...
Published by: IGI Global Scientific Publishing
Development of a student-driven undergraduate program in regenerative medicine.
As it begins to enter the clinic, regenerative medicine has the potential to revolutionize healthcare. Although there exists a growing need for individuals well-versed in the practice of regenerative medicine, few undergraduate...
The Role of Teacher Dispositions in a Global Teaching Context
Dispositions are a vital aspect to teacher preparation. Dispositions provide the holistic view to teaching future teachers that is often missing in teacher preparation programs. Commonly, the focus of training in teacher...
Published by: IGI Global Scientific Publishing
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo
Jan 04, 2021
Abstract: Aberrant soluble oligomers formed by the amyloid-β peptide (Aβ) are major pathogenic agents in the onset and progression of Alzheimer’s disease. A variety of biomolecules can influence the formation of these oligomers...
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