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Results: 140

Computational approaches for discovery of mutational signatures in cancer.

Adrian Baez-Ortega, Kevin Gori

Nov 28, 2017

The accumulation of somatic mutations in a genome is the result of the activity of one or more mutagenic processes, each of which leaves its own imprint. The study of these DNA fingerprints, termed mutational signatures, holds...

Bayes Theorem Computational Biology DNA Neoplasm Genome Human High-Throughput Nucleotide Sequencing Humans Models Genetic Models Statistical Mutation Neoplasms Sequence Analysis DNA Software

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Learning strange attractors with reservoir systems

Lyudmila Grigoryeva, Allen Hart, Juan Pablo Ortega

Sep 01, 2023

This paper shows that the celebrated embedding theorem of Takens is a particular case of a much more general statement according to which, randomly generated linear state-space representations of generic observations of an...

attractor Dynamical systems echo state property fading memory property generalized synchronization reservoir computing Takens embedding /dk/atira/pure/subjectarea/asjc/3100/3109 name=Statistical and Nonlinear Physics /dk/atira/pure/subjectarea/asjc/2600/2610 name=Mathematical Physics /dk/atira/pure/subjectarea/asjc/3100/3100 name=General Physics and Astronomy /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics

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Giant pyroelectric energy harvesting and a negative electrocaloric effect in multilayered nanostructures

Gaurav Vats, Ashok Kumar, Nora Ortega, Chris R. Bowen, Ram S. Katiyar

Apr 01, 2016

This work examines the potential of PbZr_0.53Ti_0.47O₃/CoFe₂O₄ (PZT/CFO) multi-layered nanostructures (MLNs) to achieve a giant electrocaloric effect (ECE) and enhanced...

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Understanding Public Views on a Dam Construction Boom

Christopher Schulz, Julia Martin-Ortega, Klaus Glenk

Nov 26, 2020

article water policy Water governance Hydropower Value landscapes Mato Grosso Brazil

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Pyroelectric control of magnetization for tuning thermomagnetic energy conversion and magnetocaloric effect

Gaurav Vats, Ashok Kumar, Nora Ortega, Chris R. Bowen, Ram S. Katiyar

Jul 01, 2016

Tri-layered PbZr_0.53Ti_0.47O₃/CoFe₂O₄/PbZr_0.53Ti_0.47O₃ (PZT/CFO/PZT) nanostructures have been reported to have the highest pyroelectric...

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Learning strange attractors with reservoir systems

Lyudmila Grigoryeva, Allen Hart, Juan Pablo Ortega

Sep 01, 2023

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In vitro conditions for performance evaluation of products for intravascular administration

Ricardo Díaz de León-Ortega, Deirdre M D'Arcy, Nikoletta Fotaki

Feb 15, 2020

Currently, there are no compendial in vitro release tests specifically indicated for parenteral formulations. Consideration of biorelevant and clinically relevant test media represents a valuable approach for the development...

Amphotericin B biorelevant Clinically relevant degradation Dissolution Solubility /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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In vitro conditions for performance evaluation of products for intravascular administration

Ricardo Díaz de León-Ortega, Deirdre M D'Arcy, Nikoletta Fotaki

Feb 15, 2020

Amphotericin B biorelevant Clinically relevant degradation Dissolution Solubility /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Cover Image for Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

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Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

Raj Sengupta, Helena Marzo-Ortega, Dennis McGonagle, Alison Wadeley, Alexander N Bennett

Feb 01, 2018

OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis.

METHODS: There were 109...

Journal Article

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In vitro - in vivo relations for the parenteral liposomal formulation of Amphotericin B

R. Díaz de León–Ortega, D. M. D'Arcy, D. A. Lamprou, N. Fotaki

Feb 28, 2021

In vitro release testing is a useful tool for the quality control of controlled release parenteral formulations, but in vitro release test conditions that reflect or are able to predict the in vivo performance are...

Amphotericin B Clinically in vitro Liposomes modeling PBPK PBPKPD release Relevant /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Giant pyroelectric energy harvesting and a negative electrocaloric effect in multilayered nanostructures

Gaurav Vats, Ashok Kumar, Nora Ortega, Chris R. Bowen, Ram S. Katiyar

Apr 01, 2016

This work examines the potential of PbZr_0.53Ti_0.47O₃/CoFe₂O₄ (PZT/CFO) multi-layered nanostructures (MLNs) to achieve a giant electrocaloric effect (ECE) and enhanced...

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The Design and Development of Instrumented Toys for the Assessment of Infant Cognitive Flexibility.

Vishal Ramanathan, Mohammad Zaidi Ariffin, Guo Dong Goh, Guo Liang Goh, Mohammad Adhimas Rikat, Xing Xi Tan, Wai Yee Yeong, Juan-Pablo Ortega, Victoria Leong, Domenico Campolo

Apr 05, 2023

3D printing Barometric Force Sensing Ecological Behavioural Assessment Executive Function Development Inertial Motion Detection Instrumented Toys Humans Infant Cognition Data Collection Play and Playthings

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New opabiniid diversifies the weirdest wonders of the euarthropod stem group.

Stephen Pates, Joanna M Wolfe, Rudy Lerosey-Aubril, Allison C Daley, Javier Ortega-Hernández

Mar 13, 2022

Once considered 'weird wonders' of the Cambrian, the emblematic Burgess Shale animals Anomalocaris and Opabinia are now recognized as lower stem-group euarthropods and have provided crucial data for constraining the polarity of...

Cambrian Euarthropoda Opabiniidae Wheeler Formation phylogenetics treespace Animals Arthropods Biological Evolution Fossils Phylogeny

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Pyroelectric control of magnetization for tuning thermomagnetic energy conversion and magnetocaloric effect

Gaurav Vats, Ashok Kumar, Nora Ortega, Chris R. Bowen, Ram S. Katiyar

Jul 01, 2016

Tri-layered PbZr_0.53Ti_0.47O₃/CoFe₂O₄/PbZr_0.53Ti_0.47O₃ (PZT/CFO/PZT) nanostructures have been reported to have the highest pyroelectric...

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Immersion and Invariance Stabilization of Nonlinear Systems Via Virtual and Horizontal Contraction

L Wang, F Forni, R Ortega, Z Liu, H Su

Dec 05, 2016

Nonlinear control Stability Stabilization

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Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

Raj Sengupta, Helena Marzo-Ortega, Dennis McGonagle, Alison Wadeley, Alexander N Bennett

Feb 01, 2018

OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis.

METHODS: There were 109...

Journal Article

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In vitro - in vivo relations for the parenteral liposomal formulation of Amphotericin B

R. Díaz de León–Ortega, D. M. D'Arcy, D. A. Lamprou, N. Fotaki

Feb 28, 2021

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Cover Image for Investigation and simulation of dissolution with concurrent degradation under healthy and hypoalbuminaemic simulated parenteral conditions- case example Amphotericin B

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Investigation and simulation of dissolution with concurrent degradation under healthy and hypoalbuminaemic simulated parenteral conditions- case example Amphotericin B

Ricardo Diaz De Leon-Ortega, Deirdre Maria D'Arcy, A. Bolhuis, N. Fotaki

Jun 01, 2018

Guidance on dissolution testing for parenteral formulations is limited and not often related in vivo performance. Critically ill patients represent a target cohort, frequently hypoalbuminaemic, to whom certain parenteral...

albumin Amphotericin B biorelevant degradation Dissolution Hypoalbuminaemia Solubility /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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New opabiniid diversifies the weirdest wonders of the euarthropod stem group.

Stephen Pates, Joanna M Wolfe, Rudy Lerosey-Aubril, Allison C Daley, Javier Ortega-Hernández

Feb 09, 2022

Palaeobiology RESEARCH ARTICLES Cambrian Euarthropoda Opabiniidae phylogenetics treespace Wheeler Formation

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Investigation and simulation of dissolution with concurrent degradation under healthy and hypoalbuminaemic simulated parenteral conditions- case example Amphotericin B

Ricardo Diaz De Leon-Ortega, Deirdre Maria D'Arcy, A. Bolhuis, N. Fotaki

Jun 01, 2018

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New multipodomerous appendages of stem-group euarthropods from the Cambrian (Stage 4) Guanshan Konservat-Lagerstätte.

De-Guang Jiao, Stephen Pates, Rudy Lerosey-Aubril, Javier Ortega-Hernández, Jie Yang, Tian Lan, Xi-Guang Zhang

Jan 07, 2022

Chengjiangocarididae Deuteropoda Euarthropoda Fuxianhuiida Lihuacaris ferox Radiodonta

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HIF-2α is essential for carotid body development and function.

David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall S Johnson

Apr 25, 2018

Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing forms...

Carotid Body Computational Biology Hypoxia MOUSE sympathetic nerves Systems Biology Animals Basic Helix-Loop-Helix Transcription Factors Carotid Body Cell Differentiation Mice

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Hereditary sensory and autonomic neuropathy in a family of mixed breed dogs associated with a novel RETREG1 variant.

Rodrigo Gutierrez-Quintana, Cathryn Mellersh, Annette Wessmann, Maria Ortega, Jacques Penderis, Samuel Sharpe, Eleanor Freeman, Lynn Stevenson, Louise Burmeister

Aug 23, 2021

BACKGROUND: Hereditary sensory and autonomic neuropathies (HSANs) are a group of genetic disorders affecting the peripheral nervous system. Two different associated variants have been identified in dogs: 1 in Border Collies and...

Canine electrodiagnostics Genetics Neurology Peripheral Nervous System Animals Dog Diseases Dogs Hereditary Sensory and Autonomic Neuropathies Heterozygote Homozygote Mutation Missense whole genome sequencing

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New multipodomerous appendages of stem-group euarthropods from the Cambrian (Stage 4) Guanshan Konservat-Lagerstätte

De-Guang Jiao, Stephen Pates, Rudy Lerosey-Aubril, Javier Ortega-Hernández, Jie Yang, Tian Lan, Xi-Guang Zhang

Nov 12, 2021

Organismal and evolutionary biology RESEARCH ARTICLES Chengjiangocarididae Deuteropoda Euarthropoda Fuxianhuiida Lihuacaris ferox Radiodonta

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Evaluation of remodeling and geometry on the biomechanical properties of nacreous bivalve shells.

Estefano Muñoz-Moya, Claudio M García-Herrera, Nelson A Lagos, Aldo F Abarca-Ortega, Antonio G Checa, Elizabeth M Harper

Jan 28, 2022

Mollusks have developed a broad diversity of shelled structures to protect against challenges imposed by biological interactions(e.g., predation) and constraints (e.g., [Formula: see text]-induced ocean acidification and...

Animal Shells Animals Biomechanical Phenomena Compressive Strength Ecosystem Elasticity Mollusca

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