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Results: 20
Reputation effects in the market of certifiers
Áron Tóth
Apr 01, 2014
Certifiers verify unobserved product characteristics for buyers and thereby alleviate informational asymmetries and facilitate trade. When sellers pay for the certification, however, certifiers can be tempted to bias their...
The great industry gamble
Áron Tóth
Jan 01, 0001
Industry dynamics are studied as an endogenous tournament with infinite horizon and stochastic entry. In each period, firms' investments determine their probability of surviving into the next period. This generates a survival...
The great industry gamble
Áron Tóth
Jan 01, 0001
Industry dynamics are studied as an endogenous tournament with infinite horizon and stochastic entry. In each period, firms' investments determine their probability of surviving into the next period. This generates a survival...
Reputation effects in the market of certifiers
Áron Tóth
Apr 01, 2014
Certifiers verify unobserved product characteristics for buyers and thereby alleviate informational asymmetries and facilitate trade. When sellers pay for the certification, however, certifiers can be tempted to bias their...
Human behaviour
The ratio of males to females in a population is known to influence the behaviour, life histories and demography of animals. A recent experimental study finds that sex ratio also affects human economic behaviour, and in a manner...
Human behaviour
The ratio of males to females in a population is known to influence the behaviour, life histories and demography of animals. A recent experimental study finds that sex ratio also affects human economic behaviour, and in a manner...
Quantum-Limited Directional Amplifiers with Optomechanics.
Daniel Malz, László D Tóth, Nathan R Bernier, Alexey K Feofanov, Tobias J Kippenberg, Andreas Nunnenkamp
Jan 11, 2018
Directional amplifiers are an important resource in quantum-information processing, as they protect sensitive quantum systems from excess noise. Here, we propose an implementation of phase-preserving and phase-sensitive...
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Jul 28, 2021
Soluble forms of aggregated tau misfolded protein, generally termed oligomers, are considered to be the most toxic species of the different assembly states that are the pathological components of neurodegenerative disorders....
Published by: Chemical science
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St George-Hyslop, Eva M Mandelkow, Christopher M Dobson, Lisa McConlogue, Eckhard Mandelkow, Gergely Tóth
Oct 01, 2015
The ortho effect in directed C-H activation.
Balázs L Tóth, Anna Monory, Orsolya Egyed, Attila Domján, Attila Bényei, Bálint Szathury, Zoltán Novák, András Stirling
Jul 28, 2021
The success of transition metal-catalysed ortho-directed C-H activation is often plagued by the effects of undesirable interactions between the directing group (DG) and other groups introduced into the aromatic core of the...
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Apr 22, 2020
DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.
Katalin Solti, Wei-Li Kuan, Balázs Fórizs, Gergely Kustos, Judith Mihály, Zoltán Varga, Balázs Herberth, Éva Moravcsik, Róbert Kiss, Manuela Kárpáti, Anna Mikes, Yanyan Zhao, Tímea Imre, Jean-Christophe Rochet, Franklin Aigbirhio, Caroline H Williams-Gray, Roger A Barker, Gergely Tóth
Oct 03, 2019
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F. Jobling, Shyra J. Gardai, Carlos W. Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C. Tabios, Mitali A. Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P. Anderson, Balazs Szoke, Wherly Hoffman, John Christodoulou, Ted Yednock, David A. Agard, Dale Schenk, Lisa McConlogue
Nov 17, 2020
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F Jobling, Shyra J Gardai, Carlos W Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C Tabios, Mitali A Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P Anderson, Balazs Szoke, Wherly Hoffman, John Christodoulou, Ted Yednock, David A Agard, Dale Schenk, Lisa McConlogue
Dec 20, 2019
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which...
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F Jobling, Shyra J Gardai, Carlos W Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C Tabios, Mitali A Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P Anderson, Balazs Szoke, Wherly Hoffman, John Christodoulou, Ted Yednock, David A Agard, Dale Schenk, Lisa McConlogue
Jan 09, 2020
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which...
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Arash Yavari, Claire J Stocker, Sahar Ghaffari, Edward T Wargent, Violetta Steeples, Gabor Czibik, Katalin Pinter, Mohamed Bellahcene, Angela Woods, Pablo B Martínez de Morentin, Céline Cansell, Brian YH Lam, André Chuster, Kasparas Petkevicius, Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Timothy J Pullen, Peter L Oliver, Alexander Stockenhuber, Chinh Nguyen, Merzaka Lazdam, Jacqueline F O'Dowd, Parvathy Harikumar, Mónika Tóth, Craig Beall, Theodosios Kyriakou, Julia Parnis, Dhruv Sarma, George Katritsis, Diana DJ Wortmann, Andrew R Harper, Laurence A Brown, Robin Willows, Silvia Gandra, Victor Poncio, Márcio J de Oliveira Figueiredo, Nathan R Qi, Stuart N Peirson, Rory J McCrimmon, Balázs Gereben, László Tretter, Csaba Fekete, Charles Redwood, Giles SH Yeo, Lora K Heisler, Guy A Rutter, Mark A Smith, Dominic J Withers, David Carling, Eduardo B Sternick, Jonathan RS Arch, Michael A Cawthorne, Hugh Watkins, Houman Ashrafian
Sep 03, 2019
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed...
AMP-Activated Protein Kinases Adiposity Adult aging Agouti-Related Protein Animals Arcuate Nucleus of Hypothalamus Energy Metabolism Enzyme Activation Feeding Behavior Female Heterozygote Humans Hyperphagia Hypothalamus Insulin Insulin-Secreting Cells Male Mice Mitochondria Mutation Neurons obesity Oxidative Phosphorylation Receptors Ghrelin Ribosomes Signal Transduction Transcriptome Up-Regulation