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EU-AIMS Longitudinal European Autism Project (LEAP)
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K Buitelaar, Eva Loth, Declan GM Murphy, Will Spooren, Sven Bölte, EU-AIMS LEAP group
May 09, 2019
EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has...
Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder
J Tillmann, M Uljarevic, D Crawley, G Dumas, E Loth, D Murphy, J Buitelaar, T Charman, AIMS-2-TRIALS LEAP group
Oct 26, 2020
BACKGROUND: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a...
COVID-19 health and social care access for autistic people
Bethany Oakley, Julian Tillmann, Amber Ruigrok, Aurélie Baranger, Christian Takow, Tony Charman, Emily Jones, James Cusack, Mary Doherty, Pierre Violland, Agnieszka Wroczyńska, Emily Simonoff, Jan K Buitelaar, Louise Gallagher, Declan GM Murphy, AIMS-2-TRIALS ECRAN & the AIMS-2-TRIALS Consortium
Jun 18, 2021
BACKGROUND: The global COVID-19 pandemic has had an unprecedented impact on European health and social care systems, with demands on testing, hospital and intensive care capacity exceeding available resources in many regions....
The EU-AIMS Longitudinal European Autism Project (LEAP)
Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily JH Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis, Sven Bölte, Thomas Bourgeron, Carsten Bours, Yvette de Bruijn, Bhismadev Chakrabarti, Daisy Crawley, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Hannah Hayward, Lindsay M Ham, Joerg Hipp, Rosemary J Holt, Mark H Johnson, Johan Isaksson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Amber NV Ruigrok, Barbara Ruggeri, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Jun 23, 2017
BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular...
Biomarkers Cognition EEG eye-tracking Genetics MRI Neuroimaging Adult Autism spectrum disorder Biomarkers Brain Child Eye Movement Measurements Female Genetic Heterogeneity Hair Humans Individuality Longitudinal Studies Magnetic Resonance Imaging Male Neuroimaging Patient Selection Phenotype Precision Medicine Saliva Siblings
Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project.
Julian Tillmann, Antonia San José Cáceres, Chris H Chatham, Daisy Crawley, Rosemary Holt, Bethany Oakley, Tobias Banaschewski, Simon Baron-Cohen, Sven Bölte, Jan K Buitelaar, Sarah Durston, Lindsay Ham, Eva Loth, Emily Simonoff, Will Spooren, Declan G Murphy, Tony Charman, EU-AIMS LEAP group
May 03, 2019
Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced...
adaptive functioning Autism spectrum disorder intellectual functioning psychiatric symptoms symptom severity Activities of Daily Living Adolescent Adult Age Factors Autism spectrum disorder Child Cohort Studies Europe Female Humans Intelligence Longitudinal Studies Male Phenotype Severity of Illness Index Sex Factors Young Adult
The EU-AIMS Longitudinal European Autism Project (LEAP)
Tony Charman, Eva Loth, Julian Tillmann, Daisy Crawley, Caroline Wooldridge, David Goyard, Jumana Ahmad, Bonnie Auyeung, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary J Holt, Johan Isaksson, Mark H Johnson, Emily JH Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Luke Mason, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Barbara Ruggeri, Amber NV Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San Jóse Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Jun 23, 2017
BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the...
Age autism Autism spectrum disorder Behaviours Heterogeneity IQ Phenotype sex Adolescent Adult Age Factors Autism spectrum disorder Biomarkers Child Female Genetic Heterogeneity Humans Impulsive Behavior Individuality Longitudinal Studies Male Parents Phenotype Self Report Severity of Illness Index Sex Factors Surveys and Questionnaires
Gray matter covariations and core symptoms of autism
Ting Mei, Alberto Llera, Dorothea L Floris, Natalie J Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell'Acqua, Tony Charman, Declan GM Murphy, Christine Ecker, Christian F Beckmann, Jan K Buitelaar, EU-AIMS LEAP group
Dec 07, 2020
BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of...
Group sequential designs for stepped-wedge cluster randomised trials.
BACKGROUND/AIMS: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design...
Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis
Bernard Combe, Frank Behrens, Neil McHugh, Fiona Brock, Urs Kerkmann, Blerina Kola, Gaia Gallo
Jun 01, 2016
OBJECTIVE: To evaluate the clinical/functional outcomes associated with etanercept (ETN) monotherapy versus combination therapy in psoriatic arthritis (PsA).
METHODS: Data from patients with PsA who received ETN alone...
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.
Natasha Bertelsen, Isotta Landi, Richard AI Bethlehem, Jakob Seidlitz, Elena Maria Busuoli, Veronica Mandelli, Eleonora Satta, Stavros Trakoshis, Bonnie Auyeung, Prantik Kundu, Eva Loth, Guillaume Dumas, Sarah Baumeister, Christian F Beckmann, Sven Bölte, Thomas Bourgeron, Tony Charman, Sarah Durston, Christine Ecker, Rosemary J Holt, Mark H Johnson, Emily JH Jones, Luke Mason, Andreas Meyer-Lindenberg, Carolin Moessnang, Marianne Oldehinkel, Antonio M Persico, Julian Tillmann, Steve CR Williams, Will Spooren, Declan GM Murphy, Jan K Buitelaar, EU-AIMS LEAP group, Simon Baron-Cohen, Meng-Chuan Lai, Michael V Lombardo
May 26, 2021
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural...
Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder.
Nico Bast, Luke Mason, Christine M Freitag, Tim Smith, Ana Maria Portugal, Luise Poustka, Tobias Banaschewski, Mark Johnson, EU-AIMS LEAP group
Apr 12, 2021
BACKGROUND: Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during...
Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis
Bernard Combe, Frank Behrens, Neil McHugh, Fiona Brock, Urs Kerkmann, Blerina Kola, Gaia Gallo
Jun 01, 2016
OBJECTIVE: To evaluate the clinical/functional outcomes associated with etanercept (ETN) monotherapy versus combination therapy in psoriatic arthritis (PsA).
METHODS: Data from patients with PsA who received ETN alone...
CONSORT-SPI 2018 Explanation and Elaboration
Sean Grant, Evan Mayo-Wilson, Paul Montgomery, Geraldine Macdonald, Susan Michie, Sally Hopewell, David Moher, on behalf of the CONSORT-SPI Group
Jan 08, 2019
BACKGROUND: The CONSORT (Consolidated Standards of Reporting Trials) Statement was developed to help biomedical researchers report randomised controlled trials (RCTs) transparently. We have developed an extension to the CONSORT...
CONSORT randomised controlled trial Reporting guideline reporting standards Transparency Behavior Therapy Checklist Consensus Data Accuracy Delphi Technique Endpoint Determination Humans Outcome Assessment Health Care Randomized Controlled Trials as Topic Research Design Social Environment Treatment Outcome
A systematic review of randomised controlled trials in rheumatoid arthritis
BACKGROUND: Most reported outcome measures in rheumatoid arthritis (RA) trials are composite, whose components comprise single measures that are combined into one outcome. The aims of this review were to assess the range of...
Composite outcomes imputation missing data RA sensitivity analysis Arthritis Rheumatoid Data Accuracy Data Collection Data Interpretation Statistical Humans Intention to Treat Analysis Models Statistical Patient Dropouts Randomized Controlled Trials as Topic Research Design Sample Size Treatment Outcome
Published by: Trials
Costs and staffing resource requirements for adaptive clinical trials
Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James M. S. Wason
Oct 28, 2021
Abstract: Background: Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional...
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2
Merryn Voysey, Sue Ann Costa Clemens, Shabir A Madhi, Lily Y Weckx, Pedro M Folegatti, Parvinder K Aley, Brian Angus, Vicky L Baillie, Shaun L Barnabas, Qasim E Bhorat, Sagida Bibi, Carmen Briner, Paola Cicconi, Andrea M Collins, Rachel Colin-Jones, Clare L Cutland, Thomas C Darton, Keertan Dheda, Christopher JA Duncan, Katherine RW Emary, Katie J Ewer, Lee Fairlie, Saul N Faust, Shuo Feng, Daniela M Ferreira, Adam Finn, Anna L Goodman, Catherine M Green, Christopher A Green, Paul T Heath, Catherine Hill, Helen Hill, Ian Hirsch, Susanne HC Hodgson, Alane Izu, Susan Jackson, Daniel Jenkin, Carina CD Joe, Simon Kerridge, Anthonet Koen, Gaurav Kwatra, Rajeka Lazarus, Alison M Lawrie, Alice Lelliott, Vincenzo Libri, Patrick J Lillie, Raburn Mallory, Ana VA Mendes, Eveline P Milan, Angela M Minassian, Alastair McGregor, Hazel Morrison, Yama F Mujadidi, Anusha Nana, Peter J O'Reilly, Sherman D Padayachee, Ana Pittella, Emma Plested, Katrina M Pollock, Maheshi N Ramasamy, Sarah Rhead, Alexandre V Schwarzbold, Nisha Singh, Andrew Smith, Rinn Song, Matthew D Snape, Eduardo Sprinz, Rebecca K Sutherland, Richard Tarrant, Emma C Thomson, M Estée Török, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Marion EE Watson, Christopher J Williams, Alexander D Douglas, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Andrew J Pollard, Oxford COVID Vaccine Trial Group
Dec 23, 2020
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety...
Fractionating autism based on neuroanatomical normative modeling.
Mariam Zabihi, Dorothea L Floris, Seyed Mostafa Kia, Thomas Wolfers, Julian Tillmann, Alberto Llera Arenas, Carolin Moessnang, Tobias Banaschewski, Rosemary Holt, Simon Baron-Cohen, Eva Loth, Tony Charman, Thomas Bourgeron, Declan Murphy, Christine Ecker, Jan K Buitelaar, Christian F Beckmann, Andre Marquand, EU-AIMS LEAP group
Dec 07, 2020
Autism is a complex neurodevelopmental condition with substantial phenotypic, biological, and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism into replicable cognitive or biological...
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen EL Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul CD Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene CW Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi GJ Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John JV McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, WM Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
Nov 07, 2018
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug...
Aged Body Mass Index Body Weight Cholesterol HDL Cholesterol LDL Diabetes mellitus Type 2 Female Genetic Testing Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Polymorphism Single Nucleotide Randomized Controlled Trials as Topic Risk Factors
Costs and staffing resource requirements for adaptive clinical trials
Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark Pilling, Claire Snowdon, Matthew R Sydes, Sofía S Villar, Christopher J Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James MS Wason
Nov 03, 2021
BACKGROUND: Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resources are...
Unique dynamic profiles of social attention in autistic females.
Teresa Del Bianco, Luke Mason, Meng-Chuan Lai, Eva Loth, Julian Tillmann, Tony Charman, Hannah Hayward, Teresa Gleissl, Jan K Buitelaar, Declan GM Murphy, Simon Baron-Cohen, Sven Bölte, Mark H Johnson, Emily JH Jones, EU-AIMS LEAP group
Jun 07, 2022
Costs and staffing resource requirements for adaptive clinical trials
Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A Pilling, Claire Snowdon, Matthew R Sydes, Sofía S Villar, Christopher J Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James MS Wason
Jan 06, 2022
BACKGROUND: Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resources are...
The tribulations of trials
J Withall, Colin J. Greaves, Janice L Thompson, Jolanthe De Koning, Jessica C. bollen, Sarah Moorlock, Ken R. Fox, Max Western, Tristan Snowsill, Antonieta Medina-Lara, Rosina Cross, Peter Ladlow, Gordon Taylor, Vasiliki Zisi, James Clynes, Selena Gray, Sandra Agyapong-Badu, Jack Guralnik, Jack Rejeski, Afroditi Stathi
Mar 09, 2020
Background: Challenges of recruitment to randomised controlled trials (RCTs) and successful strategies to overcome them should be clearly reported to improve recruitment into future trials. REtirement in ACTion (REACT) is a...
Mesothelioma and Radical Surgery 2 (MARS 2)
Eric Lim, Liz Darlison, John Edwards, Daisy Elliott, DA Fennell, Sanjay Popat, Robert C Rintoul, David Waller, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Alan Kirk, Pek Koh, Kelvin Lau, Talal Mansy, Nick A Maskell, Richard Milton, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Paul Taylor, Sarah Treece, Kate Ashton, Rosie Harris, Katherine Joyce, Barbara Warnes, Nicola Mills, Elizabeth A Stokes, Chris Rogers, MARS 2 Trialists
Feb 08, 2021
INTRODUCTION: Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months...
Preference for biological motion is reduced in ASD
L Mason, F Shic, T Falck-Ytter, B Chakrabarti, T Charman, E Loth, J Tillmann, T Banaschewski, S Baron-Cohen, S Bölte, J Buitelaar, S Durston, B Oranje, AM Persico, C Beckmann, T Bougeron, F Dell'Acqua, C Ecker, C Moessnang, D Murphy, MH Johnson, EJH Jones, LEAP Team*
Jan 28, 2022
BACKGROUND: The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a...
Preference for biological motion is reduced in ASD
L Mason, F Shic, T Falck-Ytter, B Chakrabarti, T Charman, E Loth, J Tillmann, T Banaschewski, Simon Baron-Cohen, S Bölte, J Buitelaar, S Durston, B Oranje, AM Persico, C Beckmann, T Bougeron, F Dell'Acqua, C Ecker, C Moessnang, D Murphy, Mark Johnson, EJH Jones, LEAP Team*
Jan 05, 2022
BACKGROUND: The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a...
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