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Prevailing Outcome Themes Reported by People With Degenerative Cervical Myelopathy
Danyal Zaman Khan, Siobhan Mairead Fitzpatrick, Bryn Hilton, Angus Gk McNair, Ellen Sarewitz, Benjamin Marshall Davies, Mark RN Kotter, AO Spine Knowledge Forum Spinal Cord Injury
Feb 26, 2021
BACKGROUND: Degenerative cervical myelopathy (DCM) arises when arthritic changes of the cervical spine cause compression and a progressive injury to the spinal cord. It is common and potentially disabling. People with DCM have...
Increasing awareness of degenerative cervical myelopathy
Carl M Zipser, Konstantinos Margetis, Karlo M Pedro, Armin Curt, Michael Fehlings, Iwan Sadler, Lindsay Tetreault, Benjamin M Davies, AO Spine RECODE DCM Steering Committee, Members of the Diagnostic Criteria Working Group
Nov 02, 2021
Degenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine specialists is often...
Traumatic spinal cord injury
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are...
A Systematic Review of Mesenchymal Stem Cells in Spinal Cord Injury, Intervertebral Disc Repair and Spinal Fusion.
Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal...
The Winnipeg Intraspinal Pressure Monitoring Study (WISP)
BACKGROUND: Research efforts have been focused on limiting secondary injury after traumatic spinal cord injury by performing spinal decompression and early optimization of spinal cord perfusion. The Winnipeg Intraspinal Pressure...
Current treatments after spinal cord injury
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as damages done to our central nervous system (CNS). The patients' physical and mental health may suffer greatly because of traumatic SCI. With the...
GFAP Expression of Radial Glial Cells of the Regenerating Spinal Cord of Axolotls
Erin Fowler
Jan 01, 0001
Unlike humans, axolotls (Ambystoma mexicanum) possess the ability to completely regenerate their spinal cord following injury. It is theorized that the population of radial glial cells in the spinal cord act as the progenitors...
Published by: Ursinus College
Axon Regeneration Between Gap-Induced Spinal Cord Injuries in the Tails of Notophthalmus viridescens
Jonathan Livezey
Jan 01, 0001
The ability of adult newts to regenerate their spinal cord is an incredible defense mechanism. After a complete tail amputation or a gap-induced spinal cord injury, newts can fully regenerate their spinal cord and surrounding...
newt Regeneration spinal cord injury gap-induced spinal cord injury axon transection Biology Life Sciences Molecular and Cellular Neuroscience
Published by: Ursinus College
Development of a core measurement set for research in degenerative cervical myelopathy
Benjamin M Davies, Alvaro Yanez Touzet, Oliver D Mowforth, Keng Siang Lee, Danyal Khan, Julio C Furlan, Michael G Fehlings, James S Harrop, Carl Moritz Zipser, Ricardo Rodrigues-Pinto, James Milligan, Ellen Sarewitz, Armin Curt, Vafa Rahimi-Movaghar, Bizhan Aarabi, Timothy F Boerger, Lindsay Tetreault, Robert Chen, James D Guest, Sukhvinder Kalsi-Ryan, Iwan Sadler, Shirley Widdop, Angus Gk McNair, Brian K Kwon, Mark RN Kotter, AO Spine RECODE-DCM Steering Committee
Jul 10, 2022
INTRODUCTION: Progress in degenerative cervical myelopathy (DCM) is hindered by inconsistent measurement and reporting. This impedes data aggregation and outcome comparison across studies. This limitation can be reversed by...
Long-Term Cultures of Spinal Cord Interneurons.
Spinal cord interneurons (SpINs) are highly diverse population of neurons that play a significant role in circuit reorganization and spontaneous recovery after spinal cord injury. Regeneration of SpIN axons across rodent spinal...
An Analysis of Microglia Within the Pro-Regenerative Spinal Cord of Ambystoma mexicanum
Andrew Voyack
Jan 01, 0001
Injury to the mammalian Central Nervous System (CNS), which consists of the brain and spinal cord, is permanent, meaning that symptoms of CNS injury such as paralysis are unable to be cured or ameliorated in humans. In...
Published by: Ursinus College
Time course of functional changes in locomotor and sensory systems after spinal cord lesions in lamprey.
Changes in motor and sensory properties occur either side of spinal cord lesion sites from lower vertebrates to humans. We have previously examined these changes in the lamprey, a model system for studying recovery after spinal...
Spinal Cord Regeneration: Investigating the Presence of Microglia and their Morphology
James Haasis
Jan 01, 0001
Setting the precedent for regenerative biology, the axolotl (Ambystoma mexicanum) faithfully reconstructs its spinal cord following injury. With application to neural regeneration and paralysis treatment in humans, research on...
Microglia spinal cord injury Spinal Cord Regeneration Biology Cell Biology Life Sciences Molecular Biology
Published by: Ursinus College
New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats.
Petr Krupa, Katerina Stepankova, Jessica CF Kwok, James W Fawcett, Veronika Cimermanova, Pavla Jendelova, Lucia Machova Urdzikova
May 18, 2021
Despite the variety of experimental models of spinal cord injury (SCI) currently used, the model of the ventral compression cord injury, which is commonly seen in humans, is very limited. Ventral balloon compression injury...
The Effects of Age on Spinal Cord Regeneration in Ambystoma mexicanum
William A Foss
Jan 01, 0001
Humans are not capable of regenerating their spinal cord in response to injury, unlike some animals. However many animals are capable of regenerating their spinal cord as an embryo. If age affects the spinal cord regeneration of...
Published by: Ursinus College
Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury.
Xin-Qiang Yao, Jia-Ying Chen, Zi-Han Yu, Zu-Cheng Huang, Regan Hamel, Yong-Qiang Zeng, Zhi-Ping Huang, Ke-Wu Tu, Jun-Hao Liu, Yan-Meng Lu, Zhi-Tao Zhou, Stefano Pluchino, Qing-An Zhu, Jian-Ting Chen
Sep 07, 2022
Macrophages and microglia play important roles in chronic neuroinflammation following spinal cord injury (SCI). Although macrophages and microglia have similar functions, their phagocytic and homeostatic abilities differ. It is...
A Review of the Segmental Diameter of the Healthy Human Spinal Cord.
Knowledge of the average size and variability of the human spinal cord can be of importance when treating pathological conditions in the spinal cord. Data on healthy human spinal cord morphometrics have been published for more...
Functional electrical stimulation cycling exercise after spinal cord injury
Jan W van der Scheer, Victoria L Goosey-Tolfrey, Sydney E Valentino, Glen M Davis, Chester H Ho
Jun 22, 2021
OBJECTIVES: The objective of this review was to summarize and appraise evidence on functional electrical stimulation (FES) cycling exercise after spinal cord injury (SCI), in order to inform the development of evidence-based...
Viability of high intensity interval training in persons with spinal cord injury-a perspective review
Spinal cord injury (SCI) leads to loss of sensory and motor function below the level of injury leading to paralysis and limitations to locomotion. Therefore, persons with SCI face various challenges in engaging in regular...
A cross-sectional comparison between cardiorespiratory fitness, level of lesion and red blood cell distribution width in adults with chronic spinal cord injury
Objectives: To assess; (1) differences in red blood cell distribution width between individuals with chronic (>1 year), motor-complete cervical (n = 21), upper-thoracic (n = 27) and thoracolumbar (n = 15) spinal cord...
A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury
Michael G Fehlings, Lindsay A Tetreault, Bizhan Aarabi, Paul Anderson, Paul M Arnold, Darrel S Brodke, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, James S Harrop, Gregory Hawryluk, Langston T Holly, Susan Howley, Tara Jeji, Sukhvinder Kalsi-Ryan, Mark Kotter, Shekar Kurpad, Brian K Kwon, Ralph J Marino, Allan R Martin, Eric Massicotte, Geno Merli, James W Middleton, Hiroaki Nakashima, Narihito Nagoshi, Katherine Palmieri, Anoushka Singh, Andrea C Skelly, Eve C Tsai, Alexander Vaccaro, Jefferson R Wilson, Albert Yee, Anthony S Burns
Oct 10, 2018
Introduction: The objective of this study is to develop guidelines that outline the appropriate type and timing of rehabilitation in patients with acute spinal cord injury (SCI). Methods: A systematic review of the literature...
Hodgkin Lymphoma Presenting With Spinal Cord Compression
Nicola Bloxham, Justin Cross, Matthew Garnett, Jessica Bewick, Kate Armon, Catherine Elizabeth Hook, Matthew Murray
Jun 29, 2021
Hodgkin lymphoma (HL) can present with extra-nodal disease, but spinal cord compression is exceptionally rare. We describe a 15-year-old presenting with hip/back pain with normal initial examination. Persistent pain and raised...
Functional electrical stimulation cycling exercise after spinal cord injury
Jan W van der Scheer, Victoria L Goosey-Tolfrey, Sydney E Valentino, Glen M Davis, Chester H Ho
Jul 28, 2021
Objectives
The objective of this review was to summarize and appraise evidence on functional electrical stimulation (FES) cycling exercise after spinal cord injury (SCI), in order to inform the development of...
spinal cord injury Exercise Systematic review clinical practice guidelines Functional electrical stimulation
Published by: Journal of neuroengineering and rehabilitation
New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats
Petr Krupa, Katerina Stepankova, Jessica CF. Kwok, James W. Fawcett, Veronika Cimermanova, Pavla Jendelova, Lucia Machova Urdzikova
Nov 09, 2020
Despite the variety of experimental models of spinal cord injury (SCI) currently used, the model of the ventral compression cord injury, which is commonly seen in humans, is very limited. Ventral balloon compression injury...
Viability of high intensity interval training in persons with spinal cord injury-a perspective review
Spinal cord injury (SCI) leads to loss of sensory and motor function below the level of injury leading to paralysis and limitations to locomotion. Therefore, persons with SCI face various challenges in engaging in regular...
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