Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene.
Ed Dicks,
Honglin Song,
Susan J Ramus,
Elke Van Oudenhove,
Jonathan P Tyrer,
Maria P Intermaggio,
Siddhartha Kar,
Patricia Harrington,
David D Bowtell,
Aocs Study Group,
Mine S Cicek,
Julie M Cunningham,
Brooke L Fridley,
Jennifer Alsop,
Mercedes Jimenez-Linan,
Anna Piskorz,
Teodora Goranova,
Emma Kent,
Nadeem Siddiqui,
James Paul,
Robin Crawford,
Samantha Poblete,
Shashi Lele,
Lara Sucheston-Campbell,
Kirsten B Moysich,
Weiva Sieh,
Valerie McGuire,
Jenny Lester,
Kunle Odunsi,
Alice S Whittemore,
Natalia Bogdanova,
Matthias Dürst,
Peter Hillemanns,
Beth Y Karlan,
Aleksandra Gentry-Maharaj,
Usha Menon,
Marc Tischkowitz,
Douglas Levine,
James D Brenton,
Thilo Dörk,
Ellen L Goode,
Simon A Gayther,
DP Paul Pharoah
Sep 11, 2018
We analyzed whole exome sequencing data in germline DNA from 412 high grade serous ovarian cancer (HGSOC) cases from The Cancer Genome Atlas Project and identified 5,517 genes harboring a predicted deleterious germline coding...