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On Allocation Algorithms for Manycore Systems With Network on Chip
Single-chip multicore processors and their network on chip interconnection mechanisms have received extensive interest since the early 2000s. The mesh topology is popular in networks on chip. A common issue in mesh is that it...
Grid & High Performance Computing Computer Science and Information Technology High Performance Computing
Published by: IGI Global Scientific Publishing
Learning Media Ethics in a Multicultural Context
The acquisition of sound media ethics competencies is a key learning outcome of media education. In a world marked by globalization and intercultural media engagements, students' possession of ethical competencies relevant to...
Published by: IGI Global Scientific Publishing
Gastrocnemius release is an effective management option for Achilles tendinopathy
PURPOSE: This systematic review aims to summarise the outcomes of gastrocnemius release in the management of Achilles Tendinopathy. METHODS: A systematic review was performed according to PRISMA guidelines. A computer-based...
Continuous Intention of Entry-Level MIS Professionals to Stay Working in the MIS Field
While many studies focused on what is management information system (MIS) major, how it attracts potential students, and describes needed skills, the perceptions of fresh MIS graduates' continuous intention to stay working in...
Published by: IGI Global Scientific Publishing
A Modular Bio-Platform Based on a Versatile Supramolecular Multi-Enzyme Complex Directly Attached to Graphene
Abeer Alshammari, Mareike G. Posner, Abhishek Upadhyay, Frank Marken, Stefan Bagby, Adelina Ilie
Aug 17, 2016
Developing generic strategies for building adaptable or multi-functional bio-platforms is challenging, in particular because protein immobilization onto surfaces often causes loss of protein function and multi-functionality...
Cycling-related orthopaedic fractures admitted to the Major Trauma Centre in the cycling capital of the UK.
Omar Jamil, Sofyan Al Shdefat, Zaki Arshad, Azeem Thahir, Fahim Anwar, Benjamin M Davies, Daud TS Chou
Sep 14, 2022
INTRODUCTION: The popularity of cycling in the United Kingdom is increasing, with a further rise likely due to recent government cycling promotion schemes. This study aims to characterise fractures sustained due to...
A Modular Bio-Platform Based on a Versatile Supramolecular Multi-Enzyme Complex Directly Attached to Graphene
Abeer Alshammari, Mareike G. Posner, Abhishek Upadhyay, Frank Marken, Stefan Bagby, Adelina Ilie
Aug 17, 2016
Developing generic strategies for building adaptable or multi-functional bio-platforms is challenging, in particular because protein immobilization onto surfaces often causes loss of protein function and multi-functionality...
Cycling-related orthopaedic fractures admitted to the Major Trauma Centre in the cycling capital of the UK.
Omar Jamil, Sofyan Al Shdefat, Zaki Arshad, Azeem Thahir, Fahim Anwar, Benjamin M Davies, Daud TS Chou
Sep 08, 2021
INTRODUCTION: The popularity of cycling in the United Kingdom is increasing, with a further rise likely due to recent government cycling promotion schemes. This study aims to characterise fractures sustained due to...
Breast screening atypia and subsequent development of cancer
David Jenkinson, Karoline Freeman, Karen Clements, Bridget Hilton, Joanne Dulson-Cox, Olive Kearins, Nigel Stallard, Matthew G Wallis, Nisha Sharma, Cliona Kirwan, Sarah Pinder, Elena Provenzano, Abeer M Shaaban, Hilary Stobart, Samantha McDonnell, Alastair M Thompson, Sian Taylor-Phillips
Jan 28, 2022
INTRODUCTION: The National Health Service (NHS) Breast Screening Programme aims to detect cancer earlier when treatment is more effective but can harm women by over diagnosing and overtreating cancers which would never have...
Arabic Clustering Through Advanced Stemming and WordNet-Based Extraction for Water Cycle Cluster
Deema Alsekait, Jaffar Atwan, Qusay Bsoul, Sharaf Alzoubi, Hanaa Fathi, Malik Jawarneh, Abeer Saber, Diaa AbdElminaam
Jan 01, 2024
Natural language processing represents human language in computational technique, which is to achieve the extraction of important words. The verbs and nouns found in the Arabic language are significantly pertinent in the process...
Published by: IGI Global Scientific Publishing
Inter- and Intra-Observer Agreement of PD-L1 SP142 Scoring in Breast Carcinoma-A Large Multi-Institutional International Study.
The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry-equivocal invasive breast cancer.
Ayaka Katayama, Jane Starczynski, Michael S Toss, Abeer M Shaaban, Elena Provenzano, Cecily M Quinn, Grace Callagy, Colin A Purdie, Rebecca Millican-Slater, David Purnell, Leena Chagla, Tetsunari Oyama, Sarah E Pinder, Steve Chan, Ian Ellis, Andrew HS Lee, Emad A Rakha
Aug 08, 2022
BACKGROUND AND AIMS: Chromosome 17 alterations affect the assessment of HER2 gene amplification in breast cancer (BC), but its clinical significance remains unclear. This study aimed to identify the prevalence of centromere...
Breast screening atypia and subsequent development of cancer
David Jenkinson, Karoline Freeman, Karen Clements, Bridget Hilton, Joanne Dulson-Cox, Olive Kearins, Nigel Stallard, Matthew G Wallis, Nisha Sharma, Cliona Kirwan, Sarah Pinder, Elena Provenzano, Abeer M Shaaban, Hilary Stobart, Samantha McDonnell, Alastair M Thompson, Sian Taylor-Phillips
Feb 09, 2022
INTRODUCTION: The National Health Service (NHS) Breast Screening Programme aims to detect cancer earlier when treatment is more effective but can harm women by over diagnosing and overtreating cancers which would never have...
Unresected screen-detected ductal carcinoma in situ
Anthony J Maxwell, Bridget Hilton, Karen Clements, David Dodwell, Joanne Dulson-Cox, Olive Kearins, Cliona Kirwan, Janet Litherland, Senthurun Mylvaganam, Elena Provenzano, Sarah E Pinder, Elinor Sawyer, Abeer M Shaaban, Nisha Sharma, Hilary Stobart, Matthew G Wallis, Alastair M Thompson
Feb 10, 2022
BACKGROUND AND AIM: The natural history of ductal carcinoma in situ (DCIS) is poorly understood. The aim of this cohort study was to determine the outcomes of women who had no surgery for screen-detected DCIS in the 6 months...
Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events
Abeer M Shaaban, Bridget Hilton, Karen Clements, Elena Provenzano, Shan Cheung, Matthew G Wallis, Elinor Sawyer, Jeremy S Thomas, Andrew M Hanby, Sarah E Pinder, Alastair M Thompson, Sloane Project Steering Committee
Mar 02, 2021
The Effectiveness of Protected Areas in Conserving Globally Threatened Western Tragopan Tragopan melanocephalus.
Muhammad Naeem Awan, Jonas Geldmann, Francis Buner, Zafeer Saqib, Arshid Pervez, Qaisar Mahmood, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Abdulaziz A Alqarawi, Elsayed Fathi Abd Allah, Tahir Ali Akbar
Mar 05, 2021
Protected areas are a critical tool to conserve biodiversity in the face of the global crisis of species extinction. Here, we present the first ever management effectiveness assessment of Pakistan's Protected Areas (PAs). We...
Predictors of pathological complete response to neoadjuvant treatment and changes to post-neoadjuvant HER2 status in HER2-positive invasive breast cancer.
Ayaka Katayama, Islam M Miligy, Sho Shiino, Michael S Toss, Karim Eldib, Sasagu Kurozumi, Cecily M Quinn, Nahla Badr, Ciara Murray, Elena Provenzano, Grace Callagy, Cian Martyn, Rebecca Millican-Slater, Colin Purdie, Dave Purnell, Sarah E Pinder, Tetsunari Oyama, Abeer M Shaaban, Ian Ellis, Andrew HS Lee, Emad A Rakha
Jun 22, 2021
The response of human epidermal growth factor receptor2 (HER2)- positive breast cancer (BC) patients to anti-HER2 targeted therapy is significant. However, the response is not uniform and a proportion of HER2-positive patients...
Cohort profile of the Sloane Project
Karen Clements, David Dodwell, Bridget Hilton, Isabella Stevens-Harris, Sarah Pinder, Matthew G Wallis, Anthony J Maxwell, Olive Kearins, Mark Sibbering, Abeer M Shaaban, Cliona Kirwan, Nisha Sharma, Hilary Stobart, Joanne Dulson-Cox, Janet Litherland, Senthurun Mylvaganam, Elena Provenzano, Elinor Sawyer, Alastair M Thompson
Jan 17, 2023
The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)-results from the UK Sloane Project.
Abeer M Shaaban, Bridget Hilton, Karen Clements, David Dodwell, Nisha Sharma, Cliona Kirwan, Elinor Sawyer, Anthony Maxwell, Matthew Wallis, Hilary Stobart, Senthurun Mylvaganam, Janet Litherland, Samantha Brace-McDonnell, Joanne Dulson-Cox, Olive Kearins, Elena Provenzano, Ian O Ellis, Sarah E Pinder, Alastair M Thompson
Dec 08, 2022
BACKGROUND: The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial. METHODS: We analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012...
The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)-results from the UK Sloane Project.
Abeer M Shaaban, Bridget Hilton, Karen Clements, David Dodwell, Nisha Sharma, Cliona Kirwan, Elinor Sawyer, Anthony Maxwell, Matthew Wallis, Hilary Stobart, Senthurun Mylvaganam, Janet Litherland, Samantha Brace-McDonnell, Joanne Dulson-Cox, Olive Kearins, Elena Provenzano, Ian O Ellis, Sarah E Pinder, Alastair M Thompson
Jan 27, 2023
BACKGROUND: The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial. METHODS: We analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012...
Cohort profile of the Sloane Project
Karen Clements, David Dodwell, Bridget Hilton, Isabella Stevens-Harris, Sarah Pinder, Matthew G Wallis, Anthony J Maxwell, Olive Kearins, Mark Sibbering, Abeer M Shaaban, Cliona Kirwan, Nisha Sharma, Hilary Stobart, Joanne Dulson-Cox, Janet Litherland, Senthurun Mylvaganam, Elena Provenzano, Elinor Sawyer, Alastair M Thompson
Dec 23, 2022
Retrospective observational study of HER2 immunohistochemistry in borderline breast cancer patients undergoing neoadjuvant therapy, with an emphasis on Group 2 (HER2/CEP17 ratio ≥2.0, HER2 copy number <4.0 signals/cell) cases.
Emad A Rakha, Islam M Miligy, Cecily M Quinn, Elena Provenzano, Abeer M Shaaban, Caterina Marchiò, Michael S Toss, Grace Gallagy, Ciara Murray, Janice Walshe, Ayaka Katayama, Karim Eldib, Nahla Badr, Bruce Tanchel, Rebecca Millican-Slater, Colin Purdie, Dave Purnell, Sarah E Pinder, Ian O Ellis, Andrew HS Lee
May 25, 2021
BACKGROUND: The ASCO/CAP guidance on HER2 testing in breast cancer (BC) has recently changed. Group 2 tumours with immunohistochemistry score 2+ and HER2/CEP17 ratio ≥2.0 and HER2 copy number <4.0 signals/cell were re-classified...
Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH)
Nicholas C Turner, Belinda Kingston, Lucy S Kilburn, Sarah Kernaghan, Andrew M Wardley, Iain R Macpherson, Richard D Baird, Rebecca Roylance, Peter Stephens, Olga Oikonomidou, Jeremy P Braybrooke, Mark Tuthill, Jacinta Abraham, Matthew C Winter, Hannah Bye, Michael Hubank, Heidrun Gevensleben, Ros Cutts, Claire Snowdon, Daniel Rea, David Cameron, Abeer Shaaban, Katrina Randle, Sue Martin, Katie Wilkinson, Laura Moretti, Judith M Bliss, Alistair Ring
Sep 14, 2020
BACKGROUND: Circulating tumour DNA (ctDNA) testing might provide a current assessment of the genomic profile of advanced cancer, without the need to repeat tumour biopsy. We aimed to assess the accuracy of ctDNA testing in...
Adult Aged Biomarkers Tumor Breast Neoplasms Circulating Tumor DNA Estrogen Receptor alpha Female Fulvestrant Genotype Humans Middle Aged Molecular Targeted Therapy Mutation PTEN Phosphohydrolase Prospective Studies Proto-Oncogene Proteins c-akt Pyrimidines Pyrroles Quinolines Receptor ErbB-2 Receptors Estrogen Treatment Outcome
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.
Esther H Lips, Tapsi Kumar, Anargyros Megalios, Lindy L Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A Ahmed, Mingchu Xu, Alexandra W van den Belt-Dusebout, Wim Brugman, Anna K Casasent, Karen Clements, Helen R Davies, Liping Fu, Anita Grigoriadis, Timothy M Hardman, Lorraine M King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C Maley, Jeffrey R Marks, Brian A Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K Schmidt, Abeer M Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk FA Wessels, E Shelley Hwang, Nicholas E Navin, P Andrew Futreal, Grand Challenge PRECISION consortium, Alastair M Thompson, Jelle Wesseling, Elinor J Sawyer
Jul 10, 2022
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is...
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.
Esther H Lips, Tapsi Kumar, Anargyros Megalios, Lindy L Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A Ahmed, Mingchu Xu, Alexandra W van den Belt-Dusebout, Wim Brugman, Anna K Casasent, Karen Clements, Helen R Davies, Liping Fu, Anita Grigoriadis, Timothy M Hardman, Lorraine M King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C Maley, Jeffrey R Marks, Brian A Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K Schmidt, Abeer M Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk FA Wessels, E Shelley Hwang, Nicholas E Navin, P Andrew Futreal, Grand Challenge PRECISION consortium, Alastair M Thompson, Jelle Wesseling, Elinor J Sawyer
Jun 14, 2022
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