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Results: 93
Imaging Tau, Neuroinflammation, and Aβ in Dementia With Lewy Bodies
Elijah Mak, Ajenthan Surendranathan, Nicolas Nicastro, Franklin Aigbirhio, James Rowe, John O'Brien
Dec 20, 2018
Dementia with Lewy Bodies (DLB) is the second leading cause of degenerative dementia after Alzheimer's disease (AD).
Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.
Rhiannon S Morris, P Simon Jones, Josef A Alawneh, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, Elizabeth A Warburton, Jean-Claude Baron
Nov 06, 2018
Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of...
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
May 21, 2021
Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.
Thomas Geeraerts, Jonathan P Coles, Franklin I Aigbirhio, John D Pickard, David K Menon, Tim D Fryer, Young T Hong
Jun 18, 2018
OBJECTIVE: [(11)C]Flumazenil ([(11)C]FMZ) positron emission tomography (PET) can be used as a measure of neuronal loss. The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a...
Synthesis, in Vitro Evaluation, and Radiolabelling of Fluorinated Puromycin Analogues
Para-chloro-2-[18F]fluoroethyl-etomidate
Isabella Silins, Anders Sundin, Patrik Nordeman, Mahabuba Jahan, Sergio Estrada, Azita Monazzam, Mark Lubberink, Franklin Aigbirhio, Per Hellman, Gunnar Antoni
May 21, 2021
Introduction: [11C]Metomidate ([11C]MTO), the methyl ester analogue of etomidate, was developed as a positron emission tomography (PET) radiotracer for adrenocortical tumours and has also been suggested for imaging in primary...
18F-CETO Adrenal masses Adrenal tracer positron emission tomography primary aldosteronism Adrenal Cortex Adrenal Cortex Neoplasms Animals Drug Evaluation Preclinical Etomidate Fluorine Radioisotopes Humans hyperaldosteronism Macaca fascicularis Mice Positron-Emission Tomography Radiopharmaceuticals Rats Tissue Distribution
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A. Mendichovszky, Franklin Aigbirhio, Finian J. Leeper, Kevin M. Brindle, André A. Neves
Apr 05, 2023
article Cell Death Apoptosis tumor Imaging C2Am Trail-r2 Positron Emission Tomography (Pet) Gallium-68
Published by: MDPI
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am.
Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif A Mendichovszky, Franklin Aigbirhio, Finian J Leeper, Kevin M Brindle, André A Neves
Apr 11, 2023
There is an unmet clinical need for imaging agents capable of detecting early evidence of tumor cell death, since the timing, extent, and distribution of cell death in tumors following treatment can give an indication of...
Published by: Cancers
Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides).
Alessandra Cavaliere, Katrin C Probst, Stephen J Paisey, Christopher Marshall, Abdul KH Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D Westwell
Apr 24, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success....
Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?
Daniel J Tozer, Robin B Brown, Jessica Walsh, Young T Hong, Guy B Williams, John T O'Brien, Franklin I Aigbirhio, Tim D Fryer, Hugh S Markus
Feb 09, 2023
BACKGROUND: Recent studies have demonstrated increased microglial activation using 11C-PK11195 positron emission tomography imaging, indicating central nervous system inflammation, in cerebral small vessel disease. However...
CADASIL cerebral small vessel disease Magnetic Resonance Imaging positron emission tomography white matter Humans Diffusion tensor imaging CADASIL white matter Neuroinflammatory Diseases Magnetic Resonance Imaging Cerebral Infarction leukoencephalopathies Positron-Emission Tomography Inflammation Brain
Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.
Joseph V Guadagno, P Simon Jones, Tim D Fryer, Olivier Barret, Franklin I Aigbirhio, T Adrian Carpenter, Christopher J Price, Jonathan H Gillard, Elizabeth A Warburton, Jean-Claude Baron
Apr 05, 2011
Aged 80 and over Body Water Brain Brain Ischemia Carotid Artery Internal Dissection Cerebrovascular Circulation Diffusion Diffusion Magnetic Resonance Imaging Energy Metabolism Female Humans Hypoxia Brain Intracranial Embolism Male Middle Aged Oxygen Consumption Positron-Emission Tomography Prospective Studies Time Factors Ultrasonography Doppler Transcranial
Vascular Imaging With $^{18}$F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia
FR Joshi, R Manavaki, TD Fryer, NL Figg, JC Sluimer, FI Aigbirhio, AP Davenport, PJ Kirkpatrick, EA Warburton, JHF Rudd
Apr 05, 2017
This study was funded by a programme grant (RG/10/007/28300) from the British Heart Foundation (BHF). Dr. Joshi was supported by a BHF Clinical Research Training Fellowship (FS/12/29/29463), a British Atherosclerosis Society...
MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B Brown, Daniel J Tozer, Laurence Loubière, Young T Hong, Tim D Fryer, Guy B Williams, Martin J Graves, Franklin I Aigbirhio, John T O'Brien, Hugh S Markus
Sep 03, 2022
Background: Cerebral small vessel disease (SVD) is a common cause of stroke and cognitive impairment. Recent data has implicated neuroinflammation and increased blood-brain barrier (BBB) permeability in its pathogenesis, but...
Radiosynthesis of [ 18 F]-Labelled Pro-Nucleotides (ProTides)
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success....
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
Aug 14, 2021
A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development...
Published by: Chemical science
Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.
Andrea M Santangelo, Steve J Sawiak, Tim Fryer, Young Hong, Yoshiro Shiba, Hannah F Clarke, Patrick J Riss, Valentina Ferrari, Roger Tait, John Suckling, Franklin I Aigbirhio, Angela C Roberts
Jun 20, 2019
Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4...
Anxiety insula cortex serotonin 2A receptor serotonin transporter polymorphism Animals Anxiety Behavior Animal Callithrix Cerebral Cortex Female Fluorobenzenes Genotype Humans Injections Intramuscular Male Models Animal Piperidines Polymorphism Genetic Promoter Regions Genetic RNA Receptor Serotonin 5-HT2A Serotonin 5-HT2 Receptor Antagonists Serotonin Plasma Membrane Transport Proteins Stress Psychological
Microglial activation and tau burden predict cognitive decline in Alzheimer's disease.
Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
May 18, 2020
Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's disease. Understanding whether these features predict cognitive decline, alone or in combination, is crucial to develop new prognostic...
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.
Yanyan Zhao, Ole Tietz, Wei-Li Kuan, Abdul K Haji-Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I Aigbirhio
Jul 28, 2021
Soluble forms of aggregated tau misfolded protein, generally termed oligomers, are considered to be the most toxic species of the different assembly states that are the pathological components of neurodegenerative disorders....
Published by: Chemical science
MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B Brown, Daniel J Tozer, Laurence Loubière, Young T Hong, Tim D Fryer, Guy B Williams, Martin J Graves, Franklin I Aigbirhio, John T O'Brien, Hugh S Markus
Oct 10, 2022
BACKGROUND: Cerebral small vessel disease (SVD) is a common cause of stroke and cognitive impairment. Recent data has implicated neuroinflammation and increased blood-brain barrier (BBB) permeability in its pathogenesis, but...
Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.
Elijah Mak, Concepcion Padilla, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
Mar 07, 2019
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.
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