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Antimicrobial surface grafted thermally responsive PNIPAM-co-ALA nano-gels
Thermally responsive Poly(N-isopropylacrylamide) co-allylamine (PNIPAM-co-ALA) nano-gels were synthesised and grafted onto non-woven polypropylene. Silver nitrate was incorporated into the nano-gels in their expanded state and...
Student Perspective-Based Evaluation of Online Transition During the COVID-19 Outbreak
Due to the COVID-19 pandemic, many higher education institutes shifted to online learning with the precautionary measures taken by governments. This transition was very rapid and sudden, which brought challenges to all learning...
Published by: IGI Global Scientific Publishing
Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit.
William Sage, Mathew Guilfoyle, Catriona Luney, Adam Young, Rohitashwa Sinha, Donatella Sgubin, Joseph H McAbee, Ruichong Ma, Sarah Jefferies, Rajesh Jena, Fiona Harris, Kieren Allinson, Tomasz Matys, Wendi Qian, Thomas Santarius, Stephen Price, Colin Watts
May 25, 2018
Grade IV glioma is the most common and aggressive primary brain tumour. Gross total resection with 5-aminolevulinic acid (5-ALA) guided surgery combined with local chemotherapy (carmustine wafers) is an attractive treatment...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
An Evaluation of the Tolerability and Feasibility of Combining 5-Amino-Levulinic Acid (5-ALA) with BCNU Wafers in the Surgical Management of Primary Glioblastoma.
Colin Watts, Keyoumars Ashkan, Michael D Jenkinson, Stephen J Price, Thomas Santarius, Tomasz Matys, Ting Ting Zhang, Alina Finch, Peter Collins, Kieren Allinson, Sarah J Jefferies, Daniel J Scoffings, Athanasios Zisakis, Mark Phillips, Katharina Wanek, Paul Smith, Laura Clifton-Hadley, Nicholas Counsell
Sep 05, 2021
Background Glioblastoma (GBM) is the commonest primary malignant brain tumour in adults and effective treatment options are limited. Combining local chemotherapy with enhanced surgical resection using 5-aminolevulinic acid...
Antimicrobial surface grafted thermally responsive PNIPAM-co-ALA nano-gels
Thermally responsive Poly(N-isopropylacrylamide) co-allylamine (PNIPAM-co-ALA) nano-gels were synthesised and grafted onto non-woven polypropylene. Silver nitrate was incorporated into the nano-gels in their expanded state and...
Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas
Georgios Solomou, Aref-Ali Gharooni, Waqqas Patel, Conor S Gillespie, Melissa Gough, Ashwin Venkatesh, Michael TC Poon, Victoria Wykes, Stephen John Price, Michael D Jenkinson, Colin Watts, Puneet Plaha
Jul 27, 2022
INTRODUCTION: 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to...
An Evaluation of the Tolerability and Feasibility of Combining 5-Amino-Levulinic Acid (5-ALA) with BCNU Wafers in the Surgical Management of Primary Glioblastoma
Colin Watts, Keyoumars Ashkan, Michael D. Jenkinson, Stephen J. Price, Thomas Santarius, Tomasz Matys, Ting Ting Zhang, Alina Finch, Peter Collins, Kieren Allinson, Sarah J. Jefferies, Daniel J. Scoffings, Athanasios Zisakis, Mark Phillips, Katharina Wanek, Paul Smith, Laura Clifton-Hadley, Nicholas Counsell
Jul 02, 2021
Background Glioblastoma (GBM) is the commonest primary malignant brain tumour in adults and effective treatment options are limited. Combining local chemotherapy with enhanced surgical resection using 5-aminolevulinic acid...
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.
BACKGROUND: Acquiring clinically annotated, spatially stratified tissue samples from human glioblastoma (GBM) is compromised by haemorrhage, brain shift and subjective identification of 'normal' brain. We tested the use of...
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...
Aminolevulinic Acid click chemistry Fluorescence diagnosis Peptide Photodynamic therapy prodrug protoporphyrin IX /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...
Aminolevulinic Acid click chemistry Fluorescence diagnosis Peptide Photodynamic therapy prodrug protoporphyrin IX /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids.
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to...
Students, Staff to Spend Spring Break Helping Others
Winthrop University
Jan 01, 0001
Alternative Spring Break is coordinated by the Center for Career and Civic Engagement. This year's locations are Tuscaloosa, Ala., Washington, D.C. and Jacksonville, Fla.
Published by: Winthrop University
Dynamic Diastereomerism on Chiral Surfaces.
Adsorption of chiral molecules on chiral surfaces implies diastereomerism, evident in the adoption of distinct adsorption geometries. We show here that this diastereomerism produces a signature in the motion of chiral molecules...
He Ala Kuikui Lima Kānaka
This article focuses on decolonizing, or specifically Indigenizing, a school of social work that has a stated focus on Native Hawaiians, other Pacific Islanders, and Asian populations in the Pacific region. Armed with Kanaka...
Native Hawaiians Kanaka ‘Ōiwi critical race theory Indigenization decolonization social work curriculum
Published by: Memorial University of Newfoundland
He Ala Kuikui Lima Kānaka
This article focuses on decolonizing, or specifically Indigenizing, a school of social work that has a stated focus on Native Hawaiians, other Pacific Islanders, and Asian populations in the Pacific region. Armed with Kanaka...
Published by: Memorial University of Newfoundland
Identification of the Effective E-Promotional Tools on Improving Destination Brand Image
The aim of this research is to evaluate the effect of promotional tools on creating a positive destination brand image and attracting international tourists to Iran. Mixed methods were employed based on semi-structured...
Published by: IGI Global Scientific Publishing
On Integrated Peer-Assisted Learning Clusters Among Students in a Nigerian University
Peer interaction to assist and learn from each other has been extended online in recent times. This study was conducted to find the pattern of participation in integrated peer-assisted learning and to investigate factors known...
Published by: IGI Global Scientific Publishing
Dynamic Diastereomerism on Chiral Surfaces.
Adsorption of chiral molecules on chiral surfaces implies diastereomerism, evident in the adoption of distinct adsorption geometries. We show here that this diastereomerism produces a signature in the motion of chiral molecules...
A computationally efficient Bayesian seemingly unrelated regressions model for high‐dimensional quantitative trait loci discovery
Leonardo Bottolo, Marco Banterle, Sylvia Richardson, Mika Ala‐Korpela, Marjo‐Riitta Järvelin, Alex Lewin
May 09, 2021
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts.
Hugh Ramsay, Jennifer H Barnett, Graham K Murray, Jouko Miettunen, Pirjo Mäki, Marjo-Riitta Järvelin, George Davey Smith, Mika Ala-Korpela, Juha Veijola
Nov 22, 2018
BACKGROUND: Psychoses, especially schizophrenia, are often preceded by cognitive deficits and psychosis risk states. Altered metabolic profiles have been found in schizophrenia. However, the associations between metabolic...
High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease.
Verena Zuber, Dipender Gill, Mika Ala-Korpela, Claudia Langenberg, Adam Butterworth, Leonardo Bottolo, Stephen Burgess
Sep 21, 2020
BACKGROUND: Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the...
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease
Tom G Richardson, Eleanor Sanderson, Tom M Palmer, Mika Ala-Korpela, Brian A Ference, George Davey Smith, Michael V Holmes
Apr 24, 2020
BACKGROUND: Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic...
Adult Aged Apolipoprotein A-I Apolipoprotein B-100 Biomarkers Cholesterol HDL Cholesterol LDL Coronary Disease Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Multivariate Analysis Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Triglycerides
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