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Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Menopausal hormone use and ovarian cancer risk
Collaborative Group On Epidemiological Studies Of Ovarian Cancer, V Beral, K Gaitskell, C Hermon, K Moser, G Reeves, R Peto
Sep 21, 2018
BACKGROUND: Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or...
Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers
Lieske H Schrijver, Antonis C Antoniou, Håkan Olsson, Thea M Mooij, Marie-José Roos-Blom, Leyla Azarang, Julian Adlard, Munaza Ahmed, Daniel Barrowdale, Rosemarie Davidson, Alan Donaldson, Ros Eeles, D Gareth Evans, Debra Frost, Alex Henderson, Louise Izatt, Kai-Ren Ong, Valérie Bonadona, Isabelle Coupier, Laurence Faivre, Jean-Pierre Fricker, Paul Gesta, Klaartje van Engelen, Agnes Jager, Fred H Menko, Marian JE Mourits, Christian F Singer, Yen Y Tan, Lenka Foretova, Marie Navratilova, Rita K Schmutzler, Carolina Ellberg, Anne-Marie Gerdes, Trinidad Caldes, Jacques Simard, Edith Olah, Anna Jakubowska, Johanna Rantala, Ana Osorio, John L Hopper, Kelly-Anne Phillips, Roger L Milne, Mary Beth Terry, Catherine Noguès, Christoph Engel, Karin Kast, David E Goldgar, Flora E van Leeuwen, Douglas F Easton, Nadine Andrieu, Matti A Rookus, Gene Etude Prospective Sein Ovaire Sein, Hereditary Breast and Ovarian Cancer Research Group Netherlands, and International BRCA1/2 Carrier Cohort Study Epidemiological Study of Familial Breast Cancer
Apr 21, 2021
BACKGROUND: Ovarian cancer risk in BRCA1 and BRCA2 mutation carriers has been shown to decrease with longer duration of oral contraceptive use. Although the effects of using oral contraceptives in the general population are well...
Epidemiological Study of Familial Breast Cancer Gene Etude Prospective Sein Ovaire Sein Hereditary Breast and Ovarian Cancer Research Group Netherlands Humans Ovarian Neoplasms Genetic Predisposition to Disease Contraceptives Oral BRCA1 Protein BRCA2 Protein Proportional Hazards Models Retrospective Studies Cohort Studies Follow-Up Studies Mutation Adult Middle Aged Europe Female
Adult height is associated with increased risk of ovarian cancer
Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Australian Ovarian Cancer Study Group, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Jenny Chang-Claude, Audrey Y Jung, Kirsten B Moysich, Kunle Odunsi, Marc T Goodman, Lynne R Wilkens, Pamela J Thompson, Yurii B Shvetsov, Thilo Dörk, Tjoung-Won Park-Simon, Peter Hillemanns, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa M Pelttari, Arto Leminen, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Joseph L Kelley, Florian Heitz, Andreas du Bois, Philipp Harter, Ira Schwaab, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Bobbie J Rimel, Susanne K Kjaer, Estrid Høgdall, Allan Jensen, Ellen L Goode, Brooke L Fridley, Julie M Cunningham, Stacey J Winham, Graham G Giles, Fiona Bruinsma, Roger L Milne, Melissa C Southey, Michelle AT Hildebrandt, Xifeng Wu, Karen H Lu, Dong Liang, Douglas A Levine, Maria Bisogna, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Elisa V Bandera, Sara H Olson, Helga B Salvesen, Liv Cecilie Vestrheim Thomsen, Reidun K Kopperud, Line Bjorge, Lambertus A Kiemeney, Leon FAG Massuger, Tanja Pejovic, Amanda Bruegl, Linda S Cook, Nhu D Le, Kenneth D Swenerton, Angela Brooks-Wilson, Linda E Kelemen, Jan Lubiński, Tomasz Huzarski, Jacek Gronwald, Janusz Menkiszak, Nicolas Wentzensen, Louise Brinton, Hannah Yang, Jolanta Lissowska, Claus K Høgdall, Lene Lundvall, Honglin Song, Jonathan P Tyrer, Ian Campbell, Diana Eccles, James Paul, Rosalind Glasspool, Nadeem Siddiqui, Alice S Whittemore, Weiva Sieh, Valerie McGuire, Joseph H Rothstein, Steven A Narod, Catherine Phelan, Harvey A Risch, John R McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Anna H Wu, Malcolm C Pike, Chiu-Chen Tseng, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Agnieszka Budzilowska, Iwona K Rzepecka, Penelope M Webb, Ovarian Cancer Association Consortium
May 23, 2018
BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence...
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes
Peter F Rambau, Robert A Vierkant, Maria P Intermaggio, Linda E Kelemen, Marc T Goodman, Esther Herpel, Paul D Pharoah, Stefan Kommoss, Mercedes Jimenez-Linan, Beth Y Karlan, Aleksandra Gentry-Maharaj, Usha Menon, Susanna Hernando Polo, Francisco J Candido Dos Reis, Jennifer Anne Doherty, Simon A Gayther, Raghwa Sharma, Melissa C Larson, Paul R Harnett, Emma Hatfield, Jurandyr M de Andrade, Gregg S Nelson, Helen Steed, Joellen M Schildkraut, Micheal E Carney, Estrid Høgdall, Alice S Whittemore, Martin Widschwendter, Catherine J Kennedy, Frances Wang, Qin Wang, Chen Wang, Sebastian M Armasu, Frances Daley, Penny Coulson, Micheal E Jones, Micheal S Anglesio, Christine Chow, Anna de Fazio, Montserrat García-Closas, Sara Y Brucker, Cezary Cybulski, Holly R Harris, Andreas D Hartkopf, Tomasz Huzarski, Allan Jensen, Jan Lubiński, Oleg Oszurek, Javier Benitez, Fady Mina, Annette Staebler, Florin Andrei Taran, Jana Pasternak, Aline Talhouk, Mary Anne Rossing, Joy Hendley, AOCS Group, Robert P Edwards, Sian Fereday, Francesmary Modugno, Roberta B Ness, Weiva Sieh, Mona A El-Bahrawy, Stacey J Winham, Jenny Lester, Susanne K Kjaer, Jacek Gronwald, Peter Sinn, Peter A Fasching, Jenny Chang-Claude, Kirsten B Moysich, David D Bowtell, Brenda Y Hernandez, Hugh Luk, Sabine Behrens, Mitul Shah, Audrey Jung, Prafull Ghatage, Jennifer Alsop, Kathryn Alsop, Jesús García-Donas, Pamela J Thompson, Anthony J Swerdlow, Chloe Karpinskyj, Alicia Cazorla-Jiménez, María J García, Susha Deen, Lynne R Wilkens, José Palacios, Andrew Berchuck, Jennifer M Koziak, James D Brenton, Linda S Cook, Ellen L Goode, David G Huntsman, Susan J Ramus, Martin Köbel
Nov 12, 2018
We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
Clinical and pathological associations of PTEN expression in ovarian cancer
Filipe Correia Martins, Dominique-Laurent Couturier, Anna Paterson, Anthony N. Karnezis, Christine Chow, Tayyebeh M. Nazeran, Adekunle Odunsi, Aleksandra Gentry-Maharaj, Aleksandra Vrvilo, Alexander Hein, Aline Talhouk, Ana Osorio, Andreas D. Hartkopf, Angela Brooks-Wilson, Anna DeFazio, Anna Fischer, Arndt Hartmann, Brenda Y. Hernandez, Bryan M. McCauley, Chloe Karpinskyj, Christiani B. de Sousa, Claus Høgdall, Daniel G. Tiezzi, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gary Keeney, Gregg Nelson, Helen Steed, Honglin Song, Hugh Luk, Javier Benitez, Jennifer Alsop, Jennifer M. Koziak, Jenny Lester, Joseph H. Rothstein, Jurandyr M. de Andrade, Lene Lundvall, Luis Paz-Ares, Luis Robles-Díaz, Lynne R. Wilkens, Maria J. Garcia, Maria P. Intermaggio, Marie-Lyne Alcaraz, Mary A. Brett, Matthias W. Beckmann, Mercedes Jimenez-Linan, Michael Anglesio, Michael E. Carney, Michael Schneider, Nadia Traficante, Nadja Pejovic, Naveena Singh, Nhu Le, Peter Sinn, Prafull Ghatage, Ramona Erber, Robert Edwards, Robert Vierkant, Roberta B. Ness, Samuel Leung, Sandra Orsulic, Sara Y. Brucker, Scott H. Kaufmann, Sian Fereday, Simon Gayther, Stacey J. Winham, Stefan Kommoss, Tanja Pejovic, Teri A. Longacre, Valerie McGuire, Valerie Rhenius, Weiva Sieh, Yurii B. Shvetsov, Alice S. Whittemore, Annette Staebler, Beth Y. Karlan, Cristina Rodriguez-Antona, David D. Bowtell, Ellen L. Goode, Estrid Høgdall, Francisco J. Candido dos Reis, Jacek Gronwald, Jenny Chang-Claude, Kirsten B. Moysich, Linda E. Kelemen, Linda S. Cook, Marc T. Goodman, Peter A. Fasching, Robin Crawford, Suha Deen, Usha Menon, David G. Huntsman, Martin Köbel, Susan J. Ramus, Paul D. P. Pharoah, James D. Brenton
Sep 01, 2020
Abstract: Background: PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN...
Clinical and pathological associations of PTEN expression in ovarian cancer
Filipe Correia Martins, Dominique-Laurent Couturier, Anna Paterson, Anthony N Karnezis, Christine Chow, Tayyebeh M Nazeran, Adekunle Odunsi, Aleksandra Gentry-Maharaj, Aleksandra Vrvilo, Alexander Hein, Aline Talhouk, Ana Osorio, Andreas D Hartkopf, Angela Brooks-Wilson, Anna DeFazio, Anna Fischer, Arndt Hartmann, Brenda Y Hernandez, Bryan M McCauley, Chloe Karpinskyj, Christiani B de Sousa, Claus Høgdall, Daniel G Tiezzi, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gary Keeney, Gregg Nelson, Helen Steed, Honglin Song, Hugh Luk, Javier Benitez, Jennifer Alsop, Jennifer M Koziak, Jenny Lester, Joseph H Rothstein, Jurandyr M de Andrade, Lene Lundvall, Luis Paz-Ares, Luis Robles-Díaz, Lynne R Wilkens, Maria J Garcia, Maria P Intermaggio, Marie-Lyne Alcaraz, Mary A Brett, Matthias W Beckmann, Mercedes Jimenez-Linan, Michael Anglesio, Michael E Carney, Michael Schneider, Nadia Traficante, Nadja Pejovic, Naveena Singh, Nhu Le, Peter Sinn, Prafull Ghatage, Ramona Erber, Robert Edwards, Robert Vierkant, Roberta B Ness, Samuel Leung, Sandra Orsulic, Sara Y Brucker, Scott H Kaufmann, Sian Fereday, Simon Gayther, Stacey J Winham, Stefan Kommoss, Tanja Pejovic, Teri A Longacre, Valerie McGuire, Valerie Rhenius, Weiva Sieh, Yurii B Shvetsov, Alice S Whittemore, Annette Staebler, Beth Y Karlan, Cristina Rodriguez-Antona, David D Bowtell, Ellen L Goode, Estrid Høgdall, Francisco J Candido Dos Reis, Jacek Gronwald, Jenny Chang-Claude, Kirsten B Moysich, Linda E Kelemen, Linda S Cook, Marc T Goodman, Peter A Fasching, Robin Crawford, Suha Deen, Usha Menon, David G Huntsman, Martin Köbel, Susan J Ramus, Paul DP Pharoah, James D Brenton
Mar 06, 2020
BACKGROUND: PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression...
Adenocarcinoma Clear Cell Age Factors Biomarkers Tumor Carcinoma Ovarian Epithelial Cohort Studies Down-Regulation Female Gene Knockout Techniques Humans Middle Aged Neoplasm Staging Ovarian Neoplasms PTEN Phosphohydrolase Prospective Studies Receptors Androgen Receptors Estrogen Receptors Progesterone Tissue Array Analysis Tumor Suppressor Proteins
MyD88 and TLR4 Expression in Epithelial Ovarian Cancer.
Matthew S Block, Robert A Vierkant, Peter F Rambau, Stacey J Winham, Philipp Wagner, Nadia Traficante, Aleksandra Tołoczko, Daniel G Tiezzi, Florin Andrei Taran, Peter Sinn, Weiva Sieh, Raghwa Sharma, Joseph H Rothstein, Teresa Ramón Y Cajal, Luis Paz-Ares, Oleg Oszurek, Sandra Orsulic, Roberta B Ness, Gregg Nelson, Francesmary Modugno, Janusz Menkiszak, Valerie McGuire, Bryan M McCauley, Marie Mack, Jan Lubiński, Teri A Longacre, Zheng Li, Jenny Lester, Catherine J Kennedy, Kimberly R Kalli, Audrey Y Jung, Sharon E Johnatty, Mercedes Jimenez-Linan, Allan Jensen, Maria P Intermaggio, Jillian Hung, Esther Herpel, Brenda Y Hernandez, Andreas D Hartkopf, Paul R Harnett, Prafull Ghatage, José M García-Bueno, Bo Gao, Sian Fereday, Ursula Eilber, Robert P Edwards, Christiani B de Sousa, Jurandyr M de Andrade, Anita Chudecka-Głaz, Georgia Chenevix-Trench, Alicia Cazorla, Sara Y Brucker, Australian Ovarian Cancer Study Group, Jennifer Alsop, Alice S Whittemore, Helen Steed, Annette Staebler, Kirsten B Moysich, Usha Menon, Jennifer M Koziak, Stefan Kommoss, Susanne K Kjaer, Linda E Kelemen, Beth Y Karlan, David G Huntsman, Estrid Høgdall, Jacek Gronwald, Marc T Goodman, Blake Gilks, María José García, Peter A Fasching, Anna de Fazio, Suha Deen, Jenny Chang-Claude, Francisco J Candido Dos Reis, Ian G Campbell, James D Brenton, David D Bowtell, Javier Benítez, Paul DP Pharoah, Martin Köbel, Susan J Ramus, Ellen L Goode
Feb 22, 2018
OBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival....
Genetically predicted circulating protein biomarkers and ovarian cancer risk.
Daniel PC Considine, Guochong Jia, Xiang Shu, Joellen M Schildkraut, Paul DP Pharoah, Wei Zheng, Siddhartha P Kar, Ovarian Cancer Association Consortium
Dec 10, 2020
OBJECTIVE: Most women with epithelial ovarian cancer (EOC) are diagnosed after the disease has metastasized and survival in this group remains poor. Circulating proteins associated with the risk of developing EOC have the...
circulating biomarkers Circulating proteins epithelial ovarian cancer Genome-Wide Association Study risk Biomarkers Tumor Carcinoma Ovarian Epithelial Case-Control Studies England Female Genetic Predisposition to Disease Genome-Wide Association Study Germ-Line Mutation Healthy Volunteers Humans Neoplasm Invasiveness Ovarian Neoplasms Polymorphism Single Nucleotide Risk Assessment
Clinical and pathological associations of PTEN expression in ovarian cancer
Filipe Correia Martins, Dominique-Laurent Couturier, Anna Paterson, Anthony N. Karnezis, Christine Chow, Tayyebeh M. Nazeran, Adekunle Odunsi, Aleksandra Gentry-Maharaj, Aleksandra Vrvilo, Alexander Hein, Aline Talhouk, Ana Osorio, Andreas D. Hartkopf, Angela Brooks-Wilson, Anna DeFazio, Anna Fischer, Arndt Hartmann, Brenda Y. Hernandez, Bryan M. McCauley, Chloe Karpinskyj, Christiani B. de Sousa, Claus Høgdall, Daniel G. Tiezzi, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gary Keeney, Gregg Nelson, Helen Steed, Honglin Song, Hugh Luk, Javier Benitez, Jennifer Alsop, Jennifer M. Koziak, Jenny Lester, Joseph H. Rothstein, Jurandyr M. de Andrade, Lene Lundvall, Luis Paz-Ares, Luis Robles-Díaz, Lynne R. Wilkens, Maria J. Garcia, Maria P. Intermaggio, Marie-Lyne Alcaraz, Mary A. Brett, Matthias W. Beckmann, Mercedes Jimenez-Linan, Michael Anglesio, Michael E. Carney, Michael Schneider, Nadia Traficante, Nadja Pejovic, Naveena Singh, Nhu Le, Peter Sinn, Prafull Ghatage, Ramona Erber, Robert Edwards, Robert Vierkant, Roberta B. Ness, Samuel Leung, Sandra Orsulic, Sara Y. Brucker, Scott H. Kaufmann, Sian Fereday, Simon Gayther, Stacey J. Winham, Stefan Kommoss, Tanja Pejovic, Teri A. Longacre, Valerie McGuire, Valerie Rhenius, Weiva Sieh, Yurii B. Shvetsov, Alice S. Whittemore, Annette Staebler, Beth Y. Karlan, Cristina Rodriguez-Antona, David D. Bowtell, Ellen L. Goode, Estrid Høgdall, Francisco J. Candido dos Reis, Jacek Gronwald, Jenny Chang-Claude, Kirsten B. Moysich, Linda E. Kelemen, Linda S. Cook, Marc T. Goodman, Peter A. Fasching, Robin Crawford, Suha Deen, Usha Menon, David G. Huntsman, Martin Köbel, Susan J. Ramus, Paul D. P. Pharoah, James D. Brenton
Jun 18, 2021
Abstract: Background: PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN...
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer
Honglin Song, Ed M Dicks, Jonathan Tyrer, Maria Intermaggio, Georgia Chenevix-Trench, David D Bowtell, Nadia Traficante, Aocs Group, James Brenton, Teodora Goranova, Karen Hosking, Anna Piskorz, Elke van Oudenhove, Jen Doherty, Holly R Harris, Mary Anne Rossing, Matthias Duerst, Thilo Dork, Natalia V Bogdanova, Francesmary Modugno, Kirsten Moysich, Kunle Odunsi, Roberta Ness, Beth Y Karlan, Jenny Lester, Allan Jensen, Susanne Krüger Kjaer, Estrid Høgdall, Ian G Campbell, Conxi Lázaro, Miguel Angel Pujara, Julie Cunningham, Robert Vierkant, Stacey J Winham, Michelle Hildebrandt, Chad Huff, Donghui Li, Xifeng Wu, Yao Yu, Jennifer B Permuth, Douglas A Levine, Joellen M Schildkraut, Marjorie J Riggan, Andrew Berchuck, Penelope M Webb, Opal Study Group, Cezary Cybulski, Jacek Gronwald, Anna Jakubowska, Jan Lubinski, Jennifer Alsop, Patricia Harrington, Isaac Chan, Usha Menon, Celeste L Pearce, Anna H Wu, Anna de Fazio, Catherine J Kennedy, Ellen Goode, Susan Ramus, Simon Gayther, Paul Pharoah
Jun 17, 2020
Purpose: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate...
CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma
Eun-Young Kang, Ashley Weir, Nicola S Meagher, Kyo Farrington, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W Beckmann, Jessica Berger, Christiani Bisinotto, Hans Bösmüller, Jessica Boros, Alison H Brand, Angela Brooks-Wilson, Sara Y Brucker, Michael E Carney, Yovanni Casablanca, Alicia Cazorla-Jiménez, Paul A Cohen, Thomas P Conrads, Linda S Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W Cramer, Philip Crowe, Julie M Cunningham, Cezary Cybulski, Kathleen M Darcy, Mona A El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, María J García, Simon A Gayther, Aleksandra Gentry-Maharaj, C Blake Gilks, AOCS Group, Marcel Grube, Paul R Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Høgdall, Claus K Høgdall, Hugo M Horlings, David G Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E Jones, Scott H Kaufmann, Catherine J Kennedy, Dineo Khabele, Felix KF Kommoss, Roy FPM Kruitwagen, Diether Lambrechts, Nhu D Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubiński, Rashna Madan, G Larry Maxwell, Francesmary Modugno, Susan L Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, José Palacios, Celeste Leigh Pearce, Malcolm C Pike, Carmel M Quinn, Ganendra Raj Mohan, Cristina Rodríguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G Salfinger, Naoko Sasamoto, Joellen M Schildkraut, Minouk J Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B Shvetsov, Naveena Singh, Gabe S Sonke, Linda Steele, Colin JR Stewart, Karin Sundfeldt, Anthony J Swerdlow, Aline Talhouk, Adeline Tan, Sarah E Taylor, Kathryn L Terry, Aleksandra Tołoczko, Nadia Traficante, Koen K van de Vijver, Maaike A van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian van-Wagensveld, Ignace Vergote, Robert A Vierkant, Chen Wang, Lynne R Wilkens, Stacey J Winham, Anna H Wu, Javier Benitez, Andrew Berchuck, Francisco J Candido Dos Reis, Anna DeFazio, Peter A Fasching, Ellen L Goode, Marc T Goodman, Jacek Gronwald, Beth Y Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D Brenton, David D Bowtell, Paul DP Pharoah, Susan J Ramus, Martin Köbel
Jan 04, 2023
BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1...
Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
Kate Lawrenson, Fengju Song, Dennis J Hazelett, Siddhartha P Kar, Jonathan Tyrer, Catherine M Phelan, Rosario I Corona, Norma I Rodríguez-Malavé, Ji-Hei Seo, Emily Adler, Simon G Coetzee, Felipe Segato, Marcos AS Fonseca, Christopher I Amos, Michael E Carney, Georgia Chenevix-Trench, Jiyeob Choi, Jennifer A Doherty, Weihua Jia, Gang J Jin, Byoung-Gie Kim, Nhu D Le, Juyeon Lee, Lian Li, Boon K Lim, Noor A Adenan, Mika Mizuno, Boyoung Park, Celeste L Pearce, Kang Shan, Yongyong Shi, Xiao-Ou Shu, Weiva Sieh, Australian Ovarian Cancer Study Group, Pamela J Thompson, Lynne R Wilkens, Qingyi Wei, Yin L Woo, Li Yan, Beth Y Karlan, Matthew L Freedman, Houtan Noushmehr, Ellen L Goode, Andrew Berchuck, Thomas A Sellers, Soo-Hwang Teo, Wei Zheng, Keitaro Matsuo, Sue Park, Kexin Chen, Paul DP Pharoah, Simon A Gayther, Marc T Goodman
Apr 12, 2019
OBJECTIVE: Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian...
Asian ancestry ENHANCER epithelial ovarian cancer Gene regulation Genome-Wide Association Study eQTL Asian People Base Sequence Carcinoma Ovarian Epithelial Case-Control Studies Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Polymorphism Single Nucleotide Quantitative Trait Loci
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care
Garth Funston, Willie Hamilton, Gary Abel, Emma J. Crosbie, Brian Rous, Fiona M. Walter
Oct 28, 2020
Background: The serum biomarker cancer antigen 125 (CA125) is widely used as an investigation for possible ovarian cancer in symptomatic women presenting to primary care. However, its diagnostic performance in this setting is...
Serous borderline ovarian tumours
Serous borderline ovarian tumours (SBOTs) are an intermediate group of neoplasms, which have features between benign and malignant ovarian tumours and for which, fertility-sparing surgery can be offered. MRI in imaging of SBOTs...
Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
Melissa A Buckley, Nicholas T Woods, Jonathan P Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J Hazelett, Hamed S Najafabadi, Anxhela Gjyshi, Renato S Carvalho, Paulo C Lyra, Simon G Coetzee, Howard C Shen, Ally W Yang, Madalene A Earp, Sean J Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J Ramus, Catherine M Phelan, Gerhard A Coetzee, Houtan Noushmehr, Timothy R Hughes, Thomas A Sellers, Ellen L Goode, Paul D Pharoah, Simon A Gayther, Alvaro NA Monteiro, Ovarian Cancer Association Consortium
Dec 18, 2018
Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal...
Base Sequence Carcinoma Ovarian Epithelial Cell Cycle Proteins Cell Line Tumor Chromosome Mapping Chromosomes Human Pair 9 Cystadenocarcinoma Serous DNA Neoplasm DNA-Binding Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study HEK293 Cells Humans Linkage Disequilibrium Ovarian Neoplasms Polymorphism Single Nucleotide
Emergency surgery for splenic flexure cancer
Nicola de'Angelis, Eloy Espin, Frederic Ris, Filippo Landi, Bertrand Le Roy, Federico Coccolini, Valerio Celentano, Angela Gurrado, Denis Pezet, Giorgio Bianchi, Riccardo Memeo, Giulio C Vitali, Alejandro Solis, Christine Denet, Salomone Di Saverio, Gian Luigi de'Angelis, Miquel Kraft, Paula Gonzálvez-Guardiola, Aine Stakelum, Fausto Catena, David Fuks, Des C Winter, Mario Testini, Aleix Martínez-Pérez, SFC Study Group
Apr 30, 2021
BACKGROUND: The effectiveness of surgical treatment for splenic flexure carcinomas (SFCs) in emergency settings remains unexplored. This study aims to compare the perioperative and long-term outcomes of different alternatives...
Ovarian Capillary Hemangioma Mimicking Carcinoma
INTRODUCTION - Vascular lesions of ovary are very rare, especially ovarian hemangiomas.
CASE REPORT – presenting a case of ovarian capillary hemangioma with massive ascites and elevated Ca 125...
Published by: IJHS Medical Association
Learning a novel technique to identify possible melanomas
Tony Watson, Fiona M Walter, Annabel Wood, Helen C Morris, Per Hall, Simone Karner, Jon D Emery
Jun 14, 2011
Abstract Background Spectrophotometric intracutaneous analysis (SIAscopy™) is a multispectral imaging technique that is used to identify 'suspicious' (i.e. potentially malignant) pigmented skin lesions for further investigation....
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Juliet D French, Sharon E Johnatty, Yi Lu, Jonathan Beesley, Bo Gao, Murugan Kalimutho, Michelle J Henderson, Amanda J Russell, Siddhartha Kar, Xiaoqing Chen, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Martin O'Reilly, Chen Wang, Darren J Korbie, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study, Diether Lambrechts, Evelyn Despierre, Els Van Nieuwenhuysen, Sandrina Lambrechts, Ignace Vergote, Beth Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Keitaro Matsuo, Satoyo Hosono, Jacobus Pisterer, Peter Hillemanns, Toru Nakanishi, Yasushi Yatabe, Marc T Goodman, Galina Lurie, Rayna K Matsuno, Pamela J Thompson, Tanja Pejovic, Yukie Bean, Florian Heitz, Philipp Harter, Andreas du Bois, Ira Schwaab, Estrid Hogdall, Susanne K Kjaer, Allan Jensen, Claus Hogdall, Lene Lundvall, Svend Aage Engelholm, Bob Brown, James M Flanagan, Michelle D Metcalf, Nadeem Siddiqui, Thomas Sellers, Brooke Fridley, Julie Cunningham, Joellen M Schildkraut, Ed Iversen, Rachel Palmieri Weber, Donal Brennan, Andrew Berchuck, Paul Pharoah, Paul Harnett, Murray D Norris, Michelle Haber, Ellen L Goode, Jason S Lee, Kum Kum Khanna, Kerstin B Meyer, Georgia Chenevix-Trench, Anna DeFazio, Stacey L Edwards, Stuart MacGregor, Ovarian Cancer Association Consortium
Mar 16, 2016
PSIP1 chromosome conformation capture epithelial ovarian cancer Genome-Wide Association Study progression free survival Adaptor Proteins Signal Transducing Apoptosis Biomarkers Tumor Cell Proliferation Chromatin Immunoprecipitation Cohort Studies Cystadenocarcinoma Serous Electrophoretic Mobility Shift Assay Enhancer Elements Genetic Fallopian Tube Neoplasms Female Follow-Up Studies Germ-Line Mutation Humans Ovarian Neoplasms Peritoneal Neoplasms Polymorphism Single Nucleotide Prognosis RNA Messenger Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Survival Rate Transcription Factors Tumor Cells Cultured
An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.
Marcus Jepson, Daisy Elliott, Carmel Conefrey, Julia Wade, Leila Rooshenas, Caroline Wilson, David Beard, Jane M Blazeby, Alison Birtle, Alison Halliday, Rob Stein, Jenny L Donovan, CSAW study group, Chemorad study group, POUT study group, ACST-2 study group, OPTIMA prelim study group
Aug 23, 2018
OBJECTIVES: To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding and recruitment. STUDY DESIGN...
Patient information qualitative research randomization Randomized controlled trials Recruitment Recruitment to RCTs Comprehension Decision Making Computer-Assisted Gambling Humans metaphor Patient Education as Topic Patient Selection qualitative research Random Allocation Randomized Controlled Trials as Topic United Kingdom
Wise Management of Ovarian Cancer
Stergios Boussios, Christos Mikropoulos, Eleftherios Samartzis, Peeter Karihtala, Michele Moschetta, Matin Sheriff, Afroditi Karathanasi, Agne Sadauskaite, Elie Rassy, Nicholas Pavlidis
May 22, 2020
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality among women. Two-thirds of patients present at advanced stage at diagnosis, and the estimated 5 year survival rate is 20-40%. This heterogeneous...
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